What part of papaya has the most papain? A deep dive into the fruit's enzyme content
                                
                                
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                                    3 min read                                
                            
                                Papain, a powerful natural enzyme present in the papaya plant, is most concentrated in the unripe, green fruit. This proteolytic enzyme is not evenly distributed, with its highest levels found in specific parts of the immature plant, not the sweet flesh of a ripe papaya.