Why do coffee and energy drinks have the opposite effect on me?
                                
                                
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                                    5 min read                                
                            
                                Genetic variations in the CYP1A2 gene can cause individuals to metabolize caffeine up to four times faster or slower than others, explaining the wide range of effects people feel. For some, this variance can result in the seemingly contradictory phenomenon of coffee and energy drinks producing opposite results.