Tag: Perioral pigmentation

Case studies have documented that hyperpigmentation, particularly around the mouth, can be a primary physical sign of vitamin B12 deficiency. This condition, known as perioral pigmentation, often occurs without other overt symptoms, making it a subtle but important marker of a nutritional imbalance. Addressing this deficiency can lead to a reversal of the skin discoloration.

While hyperpigmentation can result from various factors, an often-overlooked cause is a nutritional deficiency, particularly a lack of certain B vitamins. This is crucial to understand if you are asking 'Which deficiency causes hyperpigmentation around the mouth?' as addressing the root nutritional cause is key to resolution.

According to a 2022 case study published in *Cureus*, hyperpigmentation can be the sole presenting symptom of a vitamin B12 deficiency. So, **which vitamin deficiency causes pigmentation around the mouth** specifically? While several nutritional factors can play a role, a lack of vitamin B12 is one of the most significant and well-documented causes.