Tag: Physiological ph

Did you know that histidine is considered one of the three basic amino acids, alongside lysine and arginine, yet its unique chemical properties set it apart? Understanding what type of amino acid is histidine is key to comprehending its crucial role in enzyme active sites and protein structure, especially within the complex environment of physiological pH.

At physiological pH, which is approximately 7.4, only five of the 20 standard amino acids possess a net charge on their side chain. This critical property, determined by the chemical nature of their R-groups, dictates their role in protein structure, function, and interactions with other molecules, explaining what amino acids have a charge in a biological context.