Are Proanthocyanidin Supplements Safe? A Comprehensive Safety Guide
                                
                                
                                •
                                
                                
                        
                                    
                                    4 min read                                
                            
                                Clinical trials indicate that high dosages of proanthocyanidin-rich grape seed extract, up to 2,500 mg per day for four weeks, were generally safe and well-tolerated in healthy human volunteers. However, like any supplement, understanding potential side effects and interactions is critical before beginning a new regimen.