Why Does RBC Size Increase in B12 Deficiency?
                                
                                
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                                    4 min read                                
                            
                                According to the National Institutes of Health, B12 deficiency affects a significant portion of the global population, and one of its hallmark signs is an increase in red blood cell (RBC) size. Understanding why RBC size increase in B12 deficiency happens involves a deep dive into the cellular machinery responsible for blood cell production and the critical, indirect role of Vitamin B12 in DNA synthesis.