Tag: Secondary pellagra

While largely eliminated in developed nations, outbreaks of pellagra have still been reported in regions facing famine or during emergencies, affecting vulnerable populations. Pellagra is a systemic nutritional disease caused by a severe deficiency of niacin, also known as vitamin B3, or its essential amino acid precursor, tryptophan. The condition is classically defined by the '4 Ds': dermatitis, diarrhea, dementia, and, if left untreated, death.

While largely eliminated in developed nations due to food fortification, primary pellagra—caused by inadequate dietary niacin—remains a significant public health issue in food-limited populations globally. In industrialized countries, most cases of pellagra today are linked to underlying health conditions rather than simple diet.

Historically, pellagra was an epidemic in the early 20th-century American South, particularly among populations with corn-based diets. So, how do you get pellagra today, and what are the modern causes behind this rare but serious condition?

Once a widespread and deadly disease, pellagra cases dramatically decreased in the developed world with dietary changes and food fortification. Understanding **what is the cause of pellagra?** reveals complex issues ranging from dietary limitations to metabolic disorders affecting the absorption of niacin and tryptophan.