Tag: Sirtuins

A staggering amount of cellular research points to sirtuins as key regulators of aging, metabolism, and cellular repair. Understanding how to activate your sirtuins is a major focus in health and longevity science, offering powerful strategies to enhance your body's natural defenses against age-related decline.

According to scientific research, NAD+ levels decline by an estimated 10-80% as we age, contributing to many signs of cellular aging. When considering supplements, many people wonder, "Should I take NAD or collagen?" and the answer depends on which aspect of health you want to prioritize, as these two popular supplements work in fundamentally different ways.

Geneticist David Sinclair, a leading authority on aging, includes 1 gram of resveratrol daily in his supplement regimen, a high-level dose intended to activate sirtuin genes. This dosage is significantly higher than amounts typically found in dietary sources like red wine or grapes. Sinclair combines this potent polyphenol with nicotinamide mononucleotide (NMN) to create a synergistic effect on cellular health and energy metabolism.

In recent years, the quest for longevity has propelled Nicotinamide Mononucleotide (NMN) and Resveratrol into the scientific spotlight, with animal studies showing they can significantly impact cellular health. Understanding what is better, NMN or resveratrol, requires an exploration of their different mechanisms and how they influence the body's aging processes at a cellular level.

As NAD+ levels naturally decline with age, numerous studies suggest this is a key factor in age-related health issues. Nicotinamide riboside (NR), a unique form of vitamin B3, acts as a potent precursor to NAD+ and is a popular supplement for addressing this decline.

Harvard geneticist David Sinclair emphasizes that eating less *often* is far more important for longevity than calorie counting. This philosophy is central to answering the question, "how many calories does David Sinclair eat a day?", which is primarily determined by his time-restricted, plant-focused diet rather than a fixed number.

In his research, David Sinclair found that low energy intake can trigger genetic pathways that boost the body's defenses against aging, a concept central to understanding what David Sinclair's calorie restriction actually entails. This philosophy, which he shares in his book *Lifespan*, focuses less on extreme calorie counting and more on the metabolic state of 'perceived adversity' to activate cellular repair mechanisms.

First developed by two celebrity nutritionists in 2016, the SIRT diet plan is a nutritional approach based on the theory that consuming certain foods can activate special proteins in your body called sirtuins to boost metabolism and fat burning.

According to a meta-analysis involving over 14,000 cases, supplementation with NAD+ precursors was found to improve levels of total cholesterol, LDL, and HDL in individuals with cardiovascular disease. This suggests a potential link between NAD and high cholesterol, though the effects are complex and depend on the specific precursor used.

Over time, our bodies experience a decline in cellular function, contributing to the aging process. Sirtuins, a family of protective proteins, are critical for DNA repair, metabolism, and longevity. Scientific research has identified several key supplements that can activate sirtuins, offering a promising avenue to support cellular health as we age.