Nutrition Diet: Is Splenda the same as aspartame? Unpacking the Sweeteners
                                
                                
                                •
                                
                                
                        
                                    
                                    4 min read                                
                            
                                Despite both being popular artificial sweeteners, Splenda and aspartame are fundamentally different compounds. Sucralose, the active ingredient in Splenda, is a synthetic modification of a sugar molecule, while aspartame is a synthetic dipeptide made from two amino acids.