Tag: Toppings and calories

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How many calories are in a Domino's slice? A detailed guide

Dec 25, 2025 •

4 min read

According to Domino's Cal-O-Meter, a single slice of their large hand-tossed pepperoni pizza contains approximately 324 calories. How many calories are in a Domino's slice, however, can vary widely based on your specific crust, size, and topping choices.