Tag: Transsulfuration pathway

According to research published in Nature Reviews Cancer, methionine metabolism is intricately linked to cell proliferation and overall health. The metabolism of this essential amino acid, which must be obtained through diet, involves a complex series of enzymatic reactions that influence everything from DNA methylation to antioxidant production.

An estimated 30–70% of the body's cysteine supply can be synthesized endogenously from methionine. This complex metabolic journey, known as the transsulfuration pathway, is dependent on a specific B vitamin to function correctly. This vital cofactor is vitamin B6, which plays an essential role in converting methionine to cysteine via an intermediate called homocysteine.