Tag: Trehalase deficiency

While trehalose is considered safe for most people and holds a GRAS status from the FDA, it can cause diarrhea in individuals who have a rare genetic condition called trehalase deficiency. For others, digestive upset is primarily a matter of dosage, as high intake can overwhelm the digestive system and cause osmotic diarrhea.

While most people can consume trehalose without issue, some individuals experience a rare metabolic condition known as trehalose intolerance. This occurs when the body lacks the trehalase enzyme needed to properly digest this specific type of sugar found naturally in mushrooms, yeast, and other foods.