Tag: Vddr

Affecting fewer than 1 in 200,000 children, vitamin D dependent rickets (VDDR) is a rare genetic disorder of bone development. Unlike nutritional rickets, it is not caused by a simple lack of vitamin D in the diet but rather by inherited defects that disrupt the body's ability to properly use the vitamin.

While widespread fortification has made severe vitamin D deficiency and its consequences uncommon in developed countries, rickets is still considered a rare disease that causes the bones to become soft and bend. It primarily affects children, leading to abnormal growth patterns and weakened bones that are unable to support their weight.

While most rickets cases are caused by nutritional deficiency, the genetic form is far rarer. It is vital to understand **what are the symptoms of vitamin D dependent rickets**, as they can mimic nutritional deficiencies but require a different, more specialized treatment approach for a correct diagnosis and management.

While the common form of vitamin D deficiency affects an estimated 1 billion people worldwide, the rare genetic disorders known as vitamin D deficiency type 1 and 2 are caused by specific inherited mutations. Understanding what is vitamin D deficiency type 1 and 2 requires looking beyond inadequate sunlight or diet to examine defects in the body's intricate vitamin D pathway. This article explores these distinct types, their underlying genetics, and their different therapeutic needs.