Tag: Vdr gene

Affecting fewer than 1 in 200,000 children, vitamin D dependent rickets (VDDR) is a rare genetic disorder of bone development. Unlike nutritional rickets, it is not caused by a simple lack of vitamin D in the diet but rather by inherited defects that disrupt the body's ability to properly use the vitamin.

According to studies on twins and families, the heritability of vitamin D concentration can range widely, highlighting a significant genetic component that influences individual vitamin D levels. Understanding the specific genetic variants of vitamin D can help explain why some people are more susceptible to deficiency than others, even with similar sun exposure and dietary intake.