Thiamine Pyrophosphate: The Coenzyme Form of Thiamin in Pyruvate to Acetyl CoA Conversion
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3 min read
According to the National Institutes of Health, thiamin pyrophosphate (TPP) is a cofactor for multiple critical enzymes in metabolic pathways, including the pyruvate dehydrogenase complex. This complex is responsible for the crucial reaction that converts pyruvate into acetyl CoA, effectively linking glycolysis to the citric acid cycle.