Skip to content

What are the ingredients in real MSM?

5 min read

Methylsulfonylmethane (MSM), a simple sulfur-based molecule, is the sole active ingredient in real MSM. Pure MSM is a white, crystalline solid with the chemical formula $C_2H_6O_2S$. Understanding the core ingredients and the purification process is essential for consumers, especially given the various supplement options available.

Quick Summary

The single active ingredient in real MSM is methylsulfonylmethane, a naturally occurring organic sulfur compound. Purity is a critical factor, with high-quality products like OptiMSM® achieving over 99.9% purity through distillation. The final product should be free of unwanted contaminants, though some formulations may contain minimal added fillers for stability.

Key Points

  • Core Ingredient: The only essential ingredient in real MSM is the organosulfur compound methylsulfonylmethane (MSM) itself.

  • Purity is Key: High-quality MSM products, like OptiMSM®, use distillation to achieve purity levels of 99.9% or higher, removing heavy metal contaminants.

  • Distillation vs. Crystallization: The method of purification is critical; distillation is considered superior to crystallization for removing impurities.

  • Additives: While pure MSM is the goal, some supplements contain minimal inactive ingredients, such as cellulose for capsules or silicon dioxide to prevent powder caking.

  • Source of Sulfur: MSM provides a bioavailable form of sulfur that is used by the body as a building block for amino acids and structural proteins like collagen and keratin.

In This Article

Unpacking the Core Ingredients of Real MSM

When a supplement is labeled as "real" or "pure" MSM, its ingredient list should be refreshingly short and to the point. The essence of this supplement is the organic sulfur compound itself, methylsulfonylmethane (MSM), which is also known as dimethyl sulfone ($DMSO_2$). Anything else is an additive or an impurity. While MSM exists in trace amounts in some plants, commercially available supplements are synthesized to provide a consistent, concentrated dose. The ultimate goal of manufacturers is to provide a product that is almost entirely this single molecule.

The Single Active Component: Methylsulfonylmethane

The chemical makeup of MSM is straightforward: it is an organosulfur compound with the molecular formula $C_2H_6O_2S$. This small, light molecule is highly absorbable by the body and contains over 34% elemental sulfur, a critical mineral for various bodily functions. It's a natural source of bioavailable sulfur, a building block for essential amino acids like methionine and cysteine, which are used to form proteins like collagen and keratin.

For a product to be considered "real" MSM, this is the only active ingredient. Reputable brands will often state a high percentage of purity on their labels, with premium versions often reaching 99.9% pure MSM. The purity level is a key differentiator between high-quality products and lesser alternatives that may contain higher levels of impurities left over from the manufacturing process.

The Role of Purity in MSM Ingredients

While the active ingredient is singular, the ingredients in a final product can vary depending on the purification process and the form of the supplement. High-quality MSM is manufactured through a distillation process to remove impurities, unlike cheaper alternatives that use crystallization, which can leave contaminants behind.

How Purity Affects the Final Product

The journey from raw material to a pure, consumer-grade supplement is crucial. The distillation method is preferred because it effectively removes heavy metals and other unwanted residues. The source of the initial dimethyl sulfoxide (DMSO) raw material is less important than the subsequent purification steps. It is a misconception that a "natural" source is superior, as all commercial MSM is synthetically produced but biochemically identical to the compound found in nature.

Comparison: High-Purity (OptiMSM®) vs. Standard MSM

Feature High-Purity (e.g., OptiMSM®) Standard/Crystallized MSM
Purity ≥ 99.9% Varies, often lower
Purification Method Multi-stage Distillation Crystallization
Contaminants Virtually free of contaminants and heavy metals Risk of heavy metals and impurities
FDA Status FDA-GRAS (Generally Recognized As Safe) Varies; often lacks certification
Manufacturing Origin USA (e.g., Bergstrom Nutrition) Often China or India
Certifications Kosher, Halal, ISO May lack comprehensive certifications

Understanding Additives in Formulated MSM

While the goal of real MSM is purity, some formulations, especially capsules and tablets, may contain additional ingredients to aid manufacturing or improve the final product's form. These are considered inactive ingredients and should be minimal.

Inactive Ingredients in MSM Supplements

  • Vegetable Cellulose: Often used for capsules to make them vegetarian or vegan-friendly.
  • Silicon Dioxide: A minimal amount (around 0.1%) may be added to fine MSM powder (like 'Microprill' OptiMSM®) to prevent caking and improve flow for tableting. High-purity flakes typically contain no fillers.
  • Other Synergistic Ingredients: Supplements are sometimes combined with other beneficial compounds like glucosamine, chondroitin, or vitamin C, but these are distinct from the MSM itself.

Conclusion: The Simple Truth About MSM

At its core, the only ingredient in real MSM is methylsulfonylmethane ($C_2H_6O_2S$). Any other substance is either an impurity from poor manufacturing or an intentional additive for formulation purposes. For consumers, the key takeaway is that purity, achieved through a superior distillation process, is the most important factor distinguishing a high-quality MSM supplement. Brands like OptiMSM®, which use multi-stage distillation, ensure a product that is overwhelmingly pure MSM, free from heavy metals and other contaminants. Always check the supplement facts to understand the product's true composition beyond the primary ingredient.

How is MSM produced?

MSM is typically synthesized from dimethyl sulfoxide (DMSO) through a chemical oxidation process. The resulting crude MSM is then purified, with high-quality manufacturers employing a multi-stage distillation process to achieve high purity levels, removing heavy metals and other contaminants.

What are the ingredients in real MSM? - Your Questions Answered

What is the single main ingredient in real MSM?

The single, active ingredient in real MSM is methylsulfonylmethane, a small organosulfur compound. It is also known as dimethyl sulfone or methyl sulfone and is a bioavailable source of sulfur for the body.

Is all MSM a man-made supplement?

Yes, commercial MSM supplements are synthetically produced. While MSM exists naturally in trace amounts in certain foods, it is not economically viable to extract it from these sources for supplementation. The synthesized version is biochemically identical to natural MSM.

What is the difference between distilled MSM and crystallized MSM?

Distilled MSM, used by brands like OptiMSM®, is purified through a heat-based process that effectively removes heavy metals and other contaminants, resulting in a purer final product. Crystallized MSM is purified by cooling the material, which can trap impurities within the resulting crystals.

Does high-purity MSM contain any fillers?

High-quality MSM powder, such as OptiMSM® 'Flakes,' typically contains no added fillers and is 100% pure MSM. In contrast, 'Microprill' powder, used for tableting, may contain a minimal amount of silicon dioxide to prevent caking.

Why do some MSM supplements contain other ingredients like vitamin C?

Some manufacturers combine MSM with other ingredients, such as vitamin C, to create synergistic effects and potentially improve joint health or other benefits. These are considered inactive or supporting ingredients, with MSM remaining the primary active compound.

How can I ensure the MSM supplement I buy is pure?

Look for supplements that specify a high purity level, often 99.9% or higher. Search for brands that use a distillation process, like OptiMSM®, and look for third-party certifications or quality assurance logos on the product label.

Can I tell if an MSM supplement is pure just by looking at it?

Pure MSM is a white, crystalline powder. While a visual inspection can provide some clues, it is not a definitive way to determine purity. The most reliable method is to check the product's label for purity claims and quality certifications.

Is MSM with fillers less effective?

No, the effectiveness of MSM is primarily dependent on the methylsulfonylmethane itself. The presence of minimal, food-grade fillers typically does not impact its efficacy, but choosing a product with fewer additives is often preferred for purity.

How does the body use the sulfur from MSM?

The sulfur from MSM is used as a building block for essential amino acids like methionine and cysteine, which are crucial for the body's connective tissues, hair, skin, and nails. It supports the formation of collagen and keratin, which provide structure to these tissues.

Frequently Asked Questions

The single, active ingredient in real MSM is methylsulfonylmethane, a small organosulfur compound. It is also known as dimethyl sulfone or methyl sulfone and is a bioavailable source of sulfur for the body.

Yes, commercial MSM supplements are synthetically produced. While MSM exists naturally in trace amounts in certain foods, it is not economically viable to extract it from these sources for supplementation. The synthesized version is biochemically identical to natural MSM.

Distilled MSM, used by brands like OptiMSM®, is purified through a heat-based process that effectively removes heavy metals and other contaminants, resulting in a purer final product. Crystallized MSM is purified by cooling the material, which can trap impurities within the resulting crystals.

High-quality MSM powder, such as OptiMSM® 'Flakes,' typically contains no added fillers and is 100% pure MSM. In contrast, 'Microprill' powder, used for tableting, may contain a minimal amount of silicon dioxide to prevent caking.

Some manufacturers combine MSM with other ingredients, such as vitamin C, to create synergistic effects and potentially improve joint health or other benefits. These are considered inactive or supporting ingredients, with MSM remaining the primary active compound.

Look for supplements that specify a high purity level, often 99.9% or higher. Search for brands that use a distillation process, like OptiMSM®, and look for third-party certifications or quality assurance logos on the product label.

Pure MSM is a white, crystalline powder. While a visual inspection can provide some clues, it is not a definitive way to determine purity. The most reliable method is to check the product's label for purity claims and quality certifications.

No, the effectiveness of MSM is primarily dependent on the methylsulfonylmethane itself. The presence of minimal, food-grade fillers typically does not impact its efficacy, but choosing a product with fewer additives is often preferred for purity.

The sulfur from MSM is used as a building block for essential amino acids like methionine and cysteine, which are crucial for the body's connective tissues, hair, skin, and nails. It supports the formation of collagen and keratin, which provide structure to these tissues.

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.