What are the ingredients in SPM active metagenics?

December 9, 2025 •

2 min read

Derived from highly purified fish oil, Metagenics SPM Active contains a concentrated source of Specialized Pro-Resolving Mediators (SPMs), which are advanced omega-3 derivatives. These unique lipid mediators are specifically formulated to support the body's natural resolution of inflammation and assist tissue healing.

Quick Summary

The formula features an active fractionated marine lipid concentrate from anchovy, sardine, and mackerel fish oil, standardized to specific SPMs including 18-HEPE and 17-HDHA. Mixed tocopherols are included as an antioxidant to preserve the fish oil's freshness.

Key Points

Active Ingredient: The primary component is an active fractionated marine lipid concentrate, derived from anchovy, sardine, and mackerel fish oil.
Standardized SPMs: The formula is standardized to deliver precise amounts of specific Specialized Pro-Resolving Mediators (SPMs), including 18-HEPE, 17-HDHA, and 14-HDHA.
Antioxidant Protection: Mixed tocopherols, a form of Vitamin E, are included to act as an antioxidant and prevent the fish oil from spoiling.
Softgel Construction: The supplement is encapsulated in a softgel shell composed of gelatin, glycerin, and water.
Purpose: Unlike regular fish oil, SPM Active is specifically formulated to provide the advanced compounds that actively signal the resolution of the inflammatory response.
Sourcing and Quality: The fish oil is sustainably sourced and the product is non-GMO and gluten-free, with manufacturing following GMP-certified processes.

Understanding the Core Ingredients in SPM Active Metagenics

Metagenics SPM Active is a specialized omega-3 supplement designed to support the body's natural resolution of inflammation. It provides advanced metabolites called Specialized Pro-Resolving Mediators (SPMs) derived from highly purified fish oil. Other ingredients are included for product stability and softgel formation.

The Primary Active Ingredient: Active Fractionated Marine Lipid Concentrate

The main ingredient is Active Fractionated Marine Lipid Concentrate. This concentrate is processed from sustainably sourced anchovy, sardine, and mackerel fish oil and standardized to specific SPMs.

Specialized Pro-Resolving Mediators (SPMs)

SPM Active is standardized to contain key SPMs, which are metabolic products of omega-3 fatty acids EPA and DHA. These SPMs include 18-HEPE, 17-HDHA, and 14-HDHA. They are involved in the process of resolving inflammation and promoting tissue repair.

Other Ingredients for Stability and Softgel Formulation

SPM Active softgels also contain:

Mixed Tocopherols: Antioxidants from Vitamin E to protect the fish oil from oxidation.
Softgel Shell: Made from gelatin, glycerin, and water for easy swallowing.

What Sets SPM Active Apart from Standard Omega-3 Supplements?

SPM Active differs from standard fish oil because it provides the specific SPMs that signal the end of inflammation, whereas standard fish oil contains the EPA and DHA precursors.


Feature	SPM Active	Standard Fish Oil
Primary Focus	Provides specialized pro-resolving mediators (SPMs).	Provides EPA and DHA precursors.
Processing	Fractionation and standardization for specific SPMs.	Distillation to purify EPA and DHA.
Function	Actively stimulates inflammation resolution.	Provides precursors for the body to produce SPMs.
Sourcing	Sustainably sourced from anchovy, sardine, and mackerel.	Varies by brand.
Benefit Target	Targets the resolution phase of inflammation.	Supports overall health and provides inflammatory mediator precursors.

How Sourcing and Manufacturing Affect the Product

Metagenics uses sustainably sourced fish oil, purified to remove toxins. A proprietary process fractionates the oil to standardize SPM content. The product adheres to GMP and undergoes third-party testing. More details are available on {Link: Metagenics https://www.metagenics.com/en-us/product/spm-active}.

Conclusion

SPM Active Metagenics contains a refined Active Fractionated Marine Lipid Concentrate from sustainable fish, standardized for SPMs like 18-HEPE, 17-HDHA, and 14-HDHA. Non-medicinal ingredients include mixed tocopherols and a softgel of gelatin, glycerin, and water. Its targeted composition provides the compounds that actively promote inflammation resolution, distinguishing it from standard fish oil supplements and supporting natural healing.

Frequently Asked Questions

The primary active ingredient in SPM Active is an Active Fractionated Marine Lipid Concentrate, derived from the fish oil of anchovy, sardine, and mackerel.

SPMs are advanced omega-3 fatty acid metabolites that the body produces to actively resolve inflammation and support tissue healing, rather than just blocking the inflammatory process.

Yes, the SPMs in the supplement are derived from fish oil, but the product is a highly concentrated and standardized fraction of that oil, focusing on the specific metabolites that resolve inflammation.

The product contains mixed tocopherols, a form of Vitamin E, which is used as a natural antioxidant to maintain the freshness and stability of the marine oil.

Yes, Metagenics explicitly states that SPM Active is a non-GMO and gluten-free formula, catering to a wide range of dietary needs.

While standard omega-3s provide the building blocks (EPA and DHA), SPM Active provides the specific metabolites (SPMs) that directly signal and drive the resolution phase of the inflammatory response, offering a more targeted approach.

Gelatin, glycerin, and water are used to form the softgel shell, which protects the marine lipid concentrate from degradation and makes the supplement easy to swallow.