Skip to content

What Are the Side Effects of High Oleic Safflower Oil?

4 min read

While most people can safely consume it, a 2025 report by Lybrate highlights that the safflower plant can cause adverse reactions in some individuals. It is therefore crucial to understand the potential side effects of high oleic safflower oil, which are generally associated with specific health conditions or sensitivities rather than being universally experienced. This guide details potential risks and necessary precautions.

Quick Summary

High oleic safflower oil is safe for most, but those with allergies to the Asteraceae family, bleeding issues, or who are pregnant should use caution. Excessive intake can lead to complications, and a balanced approach is recommended.

Key Points

  • Allergy Risk: People with sensitivities to the Asteraceae family (like ragweed) should be cautious due to potential allergic reactions.

  • Blood Clotting: The oil can slow blood clotting, posing risks for those with bleeding disorders or before surgery.

  • Pregnancy Warning: Safflower oil is considered potentially unsafe during pregnancy due to its ability to induce uterine contractions.

  • Diabetes Management: Some evidence suggests it may increase blood sugar levels, potentially interfering with diabetes medication.

  • Moderation is Key: While generally safe, excessive consumption could lead to complications, and a balanced fat intake is advised.

  • High vs. Low Oleic: The high-oleic variety is more heat-stable and has a lower potential for inflammation than high-linoleic safflower oil.

In This Article

While high oleic safflower oil is often lauded for its heat stability and heart-healthy monounsaturated fat content, it is not without potential risks for certain individuals. Many people can use this oil safely in moderate amounts, but caution is advised for those with specific health conditions or sensitivities. Understanding the specific side effects is essential for safe consumption and overall health management.

Potential Side Effects and Contraindications

Allergy and Hypersensitivity Reactions

The most common adverse reaction to safflower oil is an allergic response, particularly in individuals sensitive to the Asteraceae/Compositae family of plants. This family includes ragweed, chrysanthemums, marigolds, and daisies. Allergic symptoms can range from mild to severe.

List of allergic symptoms to watch for:

  • Sneezing and runny nose
  • Nasal congestion
  • Headaches and irritated eyes
  • Itchy throat
  • In severe, but rare, cases, anaphylaxis, which includes hives, shortness of breath, or shock.

Blood Clotting and Bleeding Risk

Safflower oil can have a blood-thinning effect, slowing down the process of blood clotting. This is a significant concern for several groups:

  • Individuals with bleeding disorders: People with hemophilia or other clotting disorders should not use safflower oil.
  • Before and after surgery: Due to the increased risk of bleeding, it is recommended to stop using safflower oil at least two weeks before any scheduled surgical procedure.
  • Interactions with medication: The blood-thinning effect can be amplified when combined with anticoagulant or antiplatelet drugs, such as warfarin, aspirin, or ibuprofen, potentially leading to increased bruising and bleeding risk.

Pregnancy and Uterine Contractions

It is strongly advised that pregnant women avoid consuming safflower oil. Historically, the safflower flower has been used to induce menstruation and, when used during pregnancy, can cause the uterus to contract. This can increase the risk of miscarriage. While oil extracted from the seeds is considered possibly safe for use in food, the risks associated with the flower have led to a general caution around all forms during pregnancy.

Effects on Blood Sugar Levels

For individuals managing diabetes, particularly type 2, there is some conflicting evidence regarding safflower oil's effect on blood sugar. Some early research suggests that it might increase blood glucose levels, potentially making blood sugar control more difficult. This is a concern for people on diabetes medication, as the oil could reduce the medication's effectiveness. Close monitoring of blood sugar levels is advised.

The Omega-6 and Inflammation Debate

While high oleic safflower oil is rich in monounsaturated fats (omega-9), it still contains a small amount of omega-6 polyunsaturated fatty acids (PUFAs). A balanced dietary ratio of omega-6 to omega-3 is important for health. A high intake of omega-6 fats without a corresponding balance of omega-3s could theoretically contribute to inflammatory processes in the body. However, high oleic oil has a significantly lower omega-6 content than the high-linoleic variety, making it the preferable option if this is a concern.

Potential for Liver Failure (Rare)

In extremely rare instances, and often linked to very high, unspecified doses, safflower oil has been associated with liver failure. There are only a few documented case reports of this, and the link is not clearly established. Nevertheless, this emphasizes that all oils, including seemingly healthy ones, should be consumed in moderation as part of a balanced diet.

High Oleic vs. High Linoleic: A Comparative Look

To put the side effects into proper context, it is helpful to understand the key differences between high oleic safflower oil and its more common counterpart, high linoleic safflower oil.

Feature High Oleic Safflower Oil High Linoleic Safflower Oil Extra Virgin Olive Oil
Dominant Fatty Acid Oleic Acid (Monounsaturated) Linoleic Acid (Polyunsaturated) Oleic Acid (Monounsaturated)
Smoke Point High (~450°F / 232°C) Lower (~320-330°F / 160-165°C) Moderate (~400°F / 204°C)
Heat Stability Very Stable Less Stable; Prone to oxidation Moderately Stable
Best Culinary Use High-heat cooking, frying, baking Salad dressings, cold applications Sautéing, dressings, finishing
Inflammatory Potential Lower risk compared to high linoleic Higher risk if omega-6:3 ratio is imbalanced Generally considered anti-inflammatory

Choosing a Cooking Oil Wisely

For high-heat cooking, high oleic safflower oil is a reliable choice due to its stability. However, it should not be viewed as a health panacea. A balanced intake of diverse healthy fats is the most prudent approach. For instance, incorporating extra virgin olive oil for cold uses and low-heat cooking, and limiting fried foods, contributes to a more well-rounded diet.

Conclusion

While high oleic safflower oil is a stable and versatile cooking oil suitable for high-heat applications, it is not without potential risks. Individuals with pre-existing conditions, such as bleeding disorders, sensitivities to ragweed, or diabetes, should exercise caution and consult with a healthcare provider before using it. Furthermore, pregnant women should avoid its use entirely. Consumed in moderation and as part of a balanced diet that includes other healthy fat sources, it can be a beneficial addition to the kitchen. For those with health concerns, always read labels carefully and prioritize professional medical advice. Healthline offers a useful comparison of safflower oil with other fat sources for overall health

Frequently Asked Questions

No, it is not suitable for everyone, particularly those with allergies to the Asteraceae plant family, bleeding disorders, or women who are pregnant.

Yes, it can slow blood clotting. Individuals with bleeding disorders or who are scheduled for surgery should avoid it.

Safflower oil has been known to potentially cause uterine contractions, which may increase the risk of miscarriage.

Symptoms can include sneezing, a runny nose, headaches, and irritated eyes, especially in those with existing allergies to plants like ragweed.

High-oleic oil is less prone to causing inflammation than high-linoleic oil, but some researchers suggest an imbalance of omega-6 to omega-3 fats could contribute to inflammatory processes.

Some early research suggests safflower oil might increase blood sugar levels, which could interfere with diabetes medication and warrants close monitoring.

High oleic contains more monounsaturated fats and is more heat-stable, making it suitable for high-heat cooking. High linoleic has more polyunsaturated fats and is better for cold applications like salad dressings.

In rare, but documented, cases associated with very high intake, safflower oil has been linked to liver failure. As with any oil, it should be consumed in moderation.

References

  1. 1
  2. 2
  3. 3
  4. 4

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.