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What are the Side Effects of Stevia rebaudiana Leaf Extract?

4 min read

While purified stevia leaf extracts are generally recognized as safe (GRAS) by the FDA, some individuals may still experience side effects, particularly with certain preparations or higher doses. The leaves of the Stevia rebaudiana plant have been used for centuries in South America, but modern extracts are highly concentrated and can affect people differently.

Quick Summary

Potential adverse effects of stevia extract can include digestive discomfort, blood pressure changes, and allergic reactions. The type of stevia product, its additives, and individual sensitivity influence the risk of unwanted symptoms. Interactions with certain medications should also be considered before regular use.

Key Points

  • Digestive Upset: Many stevia blends include sugar alcohols, which can cause bloating, gas, and diarrhea, not the stevia itself.

  • Blood Pressure Impact: Stevia can lower blood pressure, which benefits those with hypertension but may pose a risk to individuals with low blood pressure or those on medication.

  • Blood Sugar Considerations: Pure stevia does not affect blood sugar, but watch for additives like maltodextrin in commercial blends that can cause glucose spikes.

  • Allergic Potential: Rare allergic reactions can occur, especially in people sensitive to plants in the ragweed family, which includes stevia.

  • Moderate Intake: For most people, high-purity stevia is safe within the Acceptable Daily Intake (ADI), but excessive consumption is not recommended.

  • FDA Approval: The FDA has only approved high-purity stevia leaf extracts, not crude extracts or whole leaves, for use as sweeteners.

In This Article

Understanding Stevia: Pure Extracts vs. Other Forms

Derived from the leaves of the Stevia rebaudiana plant, stevia has gained popularity as a zero-calorie, natural sweetener. Its sweetness comes from compounds called steviol glycosides, which are up to 400 times sweeter than sucrose. However, not all stevia products are created equal, and understanding the differences is key to anticipating potential side effects. High-purity steviol glycoside extracts are approved by regulatory bodies like the FDA and are considered safe for human consumption within the acceptable daily intake (ADI). In contrast, whole stevia leaves and crude extracts are not approved due to insufficient research on their safety profile.

Digestive Issues

One of the most frequently reported side effects of stevia is gastrointestinal distress. This is often caused by the other ingredients added to many commercial stevia products, rather than the steviol glycosides themselves.

  • Sugar Alcohols: Many powdered stevia products and blends contain sugar alcohols like erythritol to provide bulk and a more sugar-like texture. While generally safe, consuming large amounts of sugar alcohols can cause digestive issues such as bloating, gas, cramping, and diarrhea in sensitive individuals.
  • Gut Microbiota Impact: Research on the effects of stevia on gut health is still developing, with some studies showing mixed results. The body's gut bacteria play a role in metabolizing stevia, and some evidence from animal studies suggests a potential disruption to the gut microbiome, though more human trials are needed.
  • Individual Sensitivity: Like any food product, some people may have a personal intolerance or sensitivity to stevia or its components, leading to mild upset stomach, nausea, or indigestion.

Blood Sugar and Blood Pressure Effects

For those monitoring their blood sugar or blood pressure, stevia's properties require careful consideration.

  • Blood Sugar Management: While pure stevia itself does not spike blood sugar and can be a good option for diabetics, some commercial blends include additives like maltodextrin or dextrose, which can raise glucose levels. Those with diabetes should always check the ingredient list to avoid these hidden sugars. In addition, stevia can interact with certain anti-diabetes medications, potentially causing blood sugar to drop too low.
  • Blood Pressure Fluctuations: Stevia has been observed to have a blood pressure-lowering effect by acting as a vasodilator, widening blood vessels. This can be beneficial for individuals with high blood pressure but poses a risk for those with already low blood pressure, potentially leading to dizziness or lightheadedness. It is crucial for people on blood pressure medication to monitor their levels and consult a doctor.

Hormonal Concerns and Reproductive Health

Though modern, purified stevia extracts are not linked to reproductive issues, early research sparked some long-standing myths.

  • Endocrine System: Some older animal studies using unrefined, crude stevia extracts suggested a potential for hormonal disruption. This research, however, is not representative of the high-purity steviol glycosides found in commercial products today. The FDA and other major regulatory bodies have found no evidence of reproductive toxicity in mammals at typical consumption levels.
  • Infertility Myth: A persistent myth, often traced back to controversial early animal studies, claimed that stevia could cause infertility. Extensive subsequent research has debunked this, finding no negative effects on fertility in both male and female animals when high-purity extracts were used.

Allergic Reactions and Other Side Effects

Allergic reactions to stevia are rare but possible, especially for individuals sensitive to other plants in the same family.

  • Asteraceae/Compositae Family: Stevia is part of the Asteraceae/Compositae family, which includes common plants like ragweed, daisies, and chrysanthemums. People with known allergies to these plants may have a higher risk of an allergic reaction to stevia.
  • Other Symptoms: Less common, but reported side effects include dizziness, headaches, and numbness.

Stevia vs. Sugar Alcohols vs. Artificial Sweeteners

Feature Stevia Leaf Extract Sugar Alcohols (e.g., Erythritol) Artificial Sweeteners (e.g., Aspartame)
Source Natural, from the Stevia rebaudiana plant Naturally found in some fruits, but commercially produced Synthetically produced chemicals
Calories Zero Often low-calorie, not zero Zero
GI Score Zero Low, but can vary by type Zero
Taste Very sweet, sometimes with a mild, bitter aftertaste Cool, sweet taste without aftertaste; less sweet than sugar Can be intensely sweet; no aftertaste
Digestive Effect Generally mild; issues often from additives Can cause bloating, gas, and diarrhea, especially in large amounts Typically no digestive issues
Health Approval FDA approved for high-purity extracts Approved by FDA Approved by FDA, but with public debate

Long-Term Usage and Moderation

For most individuals, consuming high-purity stevia extract in moderation is considered safe. The Acceptable Daily Intake (ADI) is set at 4 mg per kilogram of body weight per day (as steviol equivalents), a level far beyond what most people would consume. Excessive reliance on any non-nutritive sweetener, including stevia, may have unintended consequences on gut health and cravings. Focusing on whole, nutrient-dense foods is always the best approach for overall health.

Conclusion

While purified Stevia rebaudiana leaf extract is a widely used and safe zero-calorie sweetener for most people, potential side effects and interactions exist, particularly when consumed in excess or in products containing additional ingredients like sugar alcohols. Digestive upset, mild effects on blood pressure and blood sugar, and rare allergic reactions are the primary concerns. By choosing pure extracts and being mindful of intake, individuals can generally enjoy stevia without significant adverse effects. Consulting a healthcare provider is recommended, especially for those with pre-existing conditions or on specific medications.

Frequently Asked Questions

Yes, some people experience digestive discomfort like bloating, gas, and nausea when consuming stevia. This is often due to sugar alcohols, such as erythritol, that are mixed with stevia in many commercial products.

Stevia can have a blood pressure-lowering effect, which is why people with already low blood pressure or those taking blood pressure medication should use it with caution.

Research on stevia's impact on gut health is mixed, with some animal studies suggesting potential disruptions to gut bacteria. However, studies on humans are limited, and effects may depend on the product and individual sensitivity.

Although rare, an allergic reaction to stevia is possible, especially for individuals who are sensitive to plants in the Asteraceae family, which includes ragweed.

Yes, stevia can interact with medications for diabetes and high blood pressure, potentially amplifying their effects and causing blood sugar or blood pressure to drop too low.

High-purity stevia extracts are considered safe for pregnant women in moderation. However, it is always best to consult a healthcare provider during pregnancy or breastfeeding before using any sweetener.

Choose high-purity stevia leaf extracts that are FDA approved. Read labels carefully to ensure the product does not contain added sugar alcohols or other ingredients that might cause adverse effects.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.