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What do you mix glutamine with? A comprehensive guide for optimal absorption

3 min read

Glutamine is the most abundant amino acid in skeletal muscle, with research suggesting that stores are depleted after intense exercise. This raises the question for many individuals, what do you mix glutamine with to ensure its maximum effectiveness and absorption into the body?

Quick Summary

Glutamine powder is best mixed with cold or room-temperature liquids like water, low-sugar juices, or certain smoothies to preserve the amino acid's structure. For optimal absorption, it is often recommended to avoid mixing it with hot beverages or high-protein drinks, particularly if targeting gut health.

Key Points

  • Cold is Key: Always mix glutamine powder with cold or room-temperature liquids to prevent heat from damaging the amino acids.

  • Water is the Best Base: Plain water is the most efficient and recommended delivery method for maximizing glutamine absorption.

  • Mask the Taste with Flavor: For better flavor, mix glutamine with diluted low-sugar fruit juice, vegetable juice, or homemade flavored water.

  • Separate from High Protein: If prioritizing gut health, take glutamine at least an hour away from high-protein meals or shakes to prevent competition for absorption.

  • Use Soft Foods: For an alternative to drinks, mix glutamine powder into soft, cold foods like applesauce or yogurt.

  • Avoid Hot and Highly Acidic Drinks: Stay away from hot coffee, tea, and undiluted, highly acidic juices like grapefruit, which can degrade the supplement.

In This Article

Glutamine is a non-essential amino acid critical for numerous bodily functions, including immune support, gut health, and muscle recovery. For those supplementing with glutamine powder, proper mixing is key to maximizing its benefits, as high temperatures and certain other nutrients can interfere with absorption.

Best Beverages for Mixing Glutamine

Water is the gold standard for mixing glutamine powder due to its neutrality and efficiency as a delivery vehicle. However, there are other viable options, especially if you want to mask the supplement's natural, slightly fermented taste.

Flavorful and Effective Cold Drinks

  • Plain Water: The simplest and most effective option. Mix one scoop (5 grams) with 8 fluid ounces of cold or room-temperature water for best results.
  • Homemade Flavored Water: For those who want more flavor, infusing cold water with fresh lemon, lime, or berries is an excellent choice.
  • Low-Sugar Fruit Juice: Options like apple juice can be diluted with water to add flavor without a high sugar content, while being mindful of potential acidity issues.
  • Vegetable Juice: Juices such as beet or tomato are great for adding flavor while also providing additional nutrients.
  • Iced Tea: A lightly sweetened, chilled iced tea can be a refreshing and effective way to consume glutamine.
  • Kombucha: This fermented tea is another option, though it's important to choose one that isn't excessively acidic or heated.
  • Fruit Smoothie: A protein-free or low-protein fruit smoothie can be an excellent medium for mixing glutamine powder.

What to Avoid Mixing with Glutamine

When aiming for optimal glutamine absorption and integrity, certain combinations should be avoided.

Hot Liquids

  • Coffee, Tea, or Broth: High temperatures above 120°F (49°C) can potentially denature or damage the amino acids in glutamine, rendering them less effective. Always use cold or room-temperature liquids.

High-Protein Drinks

  • Whey Protein Shakes and Milk: While mixing glutamine with protein powder is a common practice for athletes targeting muscle recovery, it can create competition for absorption. For specific goals like supporting gut healing, it's best to take glutamine separately, ideally an hour or more away from a high-protein meal.

Highly Acidic Liquids

  • Citrus Juices (undiluted): Juices like undiluted orange or grapefruit juice are highly acidic and might degrade the glutamine, diminishing its benefits. Diluting with water can help mitigate this effect.

Mixing with Food

Glutamine powder doesn't always need to be mixed with a drink. It can also be combined with soft, room-temperature foods.

  • Yogurt or Applesauce: These are excellent choices for mixing glutamine, especially if consuming it between meals for optimal gut health support.
  • Pudding: Another soft food option that can effectively mask the taste.

Comparison of Glutamine Mixing Options

Mixing Option Primary Benefit Best For... Considerations
Cold Water Best absorption, simplest method Anyone seeking maximum glutamine efficacy and unflavored intake May not appeal to those who dislike the natural flavor
Low-Sugar Juice Adds flavor and other nutrients Masking taste, moderate flavor enhancement Can have higher sugar content; dilute and choose lower acidity options
Fruit Smoothie Versatile, great for post-workout Intense workouts, those who want a more substantial beverage Can compete for absorption if other amino acids are present (e.g., protein)
Yogurt/Applesauce Convenient, can be taken with meals Gut health support, those who prefer soft food over drinks Best taken away from high-protein meals for superior absorption

A Note on Mixing with Protein

Some fitness protocols combine glutamine with protein, especially post-workout, to aid overall muscle repair and recovery. This is acceptable for broad recovery goals, but it's important to understand the trade-off. For targeted benefits like gut health or specific absorption timing, separating glutamine from other heavy amino acid sources is the more strategic approach. The efficacy of supplemental glutamine for muscle growth in healthy adults who already consume enough protein is also debated, with some evidence suggesting little added benefit. The decision depends on your specific health and fitness goals.

Conclusion

The best way to mix glutamine largely depends on your specific health goals and personal taste preference. For maximum efficacy and simple delivery, cold water is the ideal choice. For those looking to mask the taste, low-sugar juices, vegetable juices, and certain smoothies offer excellent alternatives, provided they are cold or room temperature. Always avoid hot liquids, which can degrade the amino acids. If your primary aim is gut health, consider taking glutamine separate from high-protein meals or shakes to prevent competition for absorption. By following these guidelines, you can ensure your glutamine supplementation is as effective as possible. A helpful guide from a trusted health resource can provide further details: Mayo Clinic guide to glutamine.

Frequently Asked Questions

No, it is not recommended to mix glutamine with hot water, hot coffee, tea, or broth. High temperatures can denature the amino acids, which may reduce the effectiveness of the supplement.

While it is a common practice, mixing glutamine with a protein shake can create competition for absorption in your gastrointestinal tract. For optimal glutamine absorption, particularly for gut health benefits, it's best to take them separately.

Plain, cold or room-temperature water is considered the best liquid for mixing glutamine. It serves as an optimal delivery vehicle for the amino acids without interfering with their structure.

Yes, you can mix glutamine with low-sugar fruit juice, such as apple juice. Diluting the juice with water is often recommended to reduce the acidity and prevent the sugar from affecting absorption.

Yes, glutamine powder can be mixed with soft, cold or room-temperature foods like yogurt or applesauce. This is a good option, especially if taken away from high-protein meals.

No, complete dissolution is not required when mixing glutamine powder with a beverage or soft food. It is still effective even if it is not completely dissolved.

Glutamine can be taken at various times depending on your goals. Common times include post-workout for recovery, first thing in the morning for gut health, or between meals to maintain stable amino acid levels.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.