The Core Culprit: Glycyrrhizin
The primary source of black licorice's flavor and its most serious health risk comes from a compound called glycyrrhizin, found in the licorice root (Glycyrrhiza glabra). When consumed in high amounts, glycyrrhizin can disrupt the body's mineral balance by inhibiting an enzyme that inactivates cortisol. This leads to increased cortisol levels and a mineralocorticoid effect similar to aldosterone, a condition known as pseudohyperaldosteronism, which is the root cause of many adverse effects from excessive black licorice.
How Glycyrrhizin Disrupts Mineral Balance
The glycyrrhizin-induced increase in mineralocorticoid activity leads to sodium retention and potassium excretion. The kidneys retain sodium and water, causing fluid buildup, while potassium is excessively excreted, resulting in hypokalemia (low blood potassium).
Cardiovascular Consequences and High Blood Pressure
Increased sodium and water retention from glycyrrhizin directly contributes to hypertension (high blood pressure). This is particularly risky for individuals with existing high blood pressure or other heart conditions. Health organizations like the FDA have reported hospitalizations and serious cardiac events linked to excessive black licorice. In one instance, a man experienced cardiac arrest after consuming several bags of black licorice daily, leading to dangerously low potassium levels. Potassium levels and heart issues generally normalize after discontinuing licorice intake.
Low Potassium (Hypokalemia) and Muscle Weakness
Excessive black licorice can cause severe hypokalemia. Potassium is vital for muscle function, including the heart. Low potassium can cause fatigue, muscle cramping, numbness, difficulty breathing, and even flaccid paralysis in extreme cases.
Who is at Highest Risk?
While high consumption of real licorice is risky for anyone, certain groups are more vulnerable. Those over 40 are more susceptible to cardiovascular effects, with the FDA recommending no more than 2 ounces daily for two weeks. Individuals with pre-existing conditions like high blood pressure, heart disease, or kidney disease should avoid real licorice as glycyrrhizin can worsen these issues. Pregnant individuals should also avoid large quantities due to risks of preterm delivery and potential developmental problems. Licorice can also interact with medications for high blood pressure, diuretics, and heart drugs, increasing the risk of low potassium.
Real Black Licorice vs. Anise-Flavored Candy
Not all black licorice-flavored candies contain glycyrrhizin; many, especially in the U.S., use anise oil, which does not pose the same health risks. Always check the ingredients for licorice extract or Glycyrrhiza glabra to identify real licorice. A comparison is below:
| Feature | Genuine Black Licorice | Anise-Flavored Black Candy |
|---|---|---|
| Source of Flavor | Extract from licorice root (Glycyrrhiza glabra) | Anise oil, which mimics the flavor |
| Contains Glycyrrhizin? | Yes, contains glycyrrhizin, the active compound | No, anise oil does not contain glycyrrhizin |
| Health Risks (Daily Consumption) | High blood pressure, low potassium, heart issues | Generally safe regarding glycyrrhizin-related risks |
| Safe Daily Amount (for healthy adults) | Very low; potentially harmful at 2 ounces/day for 2 weeks | Safe in moderation as part of a balanced diet |
A Note on Deglycyrrhizinated Licorice (DGL)
Deglycyrrhizinated licorice (DGL) products have had glycyrrhizin removed, offering a safer alternative for those who enjoy the flavor. Even DGL should be consumed in moderation, particularly if used as a supplement.
Managing and Avoiding Licorice-Related Risks
To safely enjoy black licorice or its alternatives:
- Consume genuine black licorice in very small, infrequent amounts, if at all.
- Check ingredient lists for "licorice extract" or Glycyrrhiza glabra.
- Choose anise-flavored candy or DGL products as alternatives.
- Consult a doctor if you are pregnant, have heart or kidney conditions, high blood pressure, or take medications like digoxin or diuretics, regarding your licorice intake.
Conclusion
Daily consumption of real black licorice, especially in large amounts, carries significant health risks due to glycyrrhizin, which can cause high blood pressure and low potassium. By understanding these risks, checking labels, and practicing moderation, you can enjoy the flavor safely.