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What is the difference between magnesium citrate and magnesium glycinate (not glyphosate)?

4 min read

Over 60% of US adults do not get enough magnesium from their diet alone, leading many to seek supplements. However, confusing magnesium citrate with magnesium glycinate (and mistakenly calling it 'glyphosate') is common, but they serve very different purposes.

Quick Summary

Magnesium citrate primarily serves as a laxative for constipation, while magnesium glycinate provides calming effects for sleep and anxiety due to the amino acid glycine.

Key Points

  • Glyphosate Clarification: Magnesium glyphosate is a misconception; the correct supplement is magnesium glycinate.

  • Citrate for Digestion: Magnesium citrate is a mild laxative, effective for relieving occasional constipation by drawing water into the intestines.

  • Glycinate for Calm: Magnesium glycinate provides calming effects, making it ideal for sleep, relaxation, and managing anxiety.

  • Digestive Tolerance: Glycinate is gentle on the stomach and rarely causes gastrointestinal distress, unlike citrate, which can cause loose stools at higher doses.

  • Choosing the Right Type: Your health goal dictates the best choice—citrate for digestive issues and glycinate for nervous system support.

  • Combined Use: Some individuals can benefit from using both forms for different purposes, such as citrate in the morning and glycinate at night, while monitoring total intake.

In This Article

Clarifying the 'Glyphosate' Confusion

Before delving into the differences, it is crucial to address a common point of confusion. The search term "magnesium glyphosate" is based on a misunderstanding. Glyphosate is the active ingredient in many herbicides, and is not a nutritional supplement. The compound that people are typically looking for is magnesium glycinate, a highly bioavailable form of magnesium bound to the amino acid glycine. This article will proceed with the correct comparison between magnesium citrate and magnesium glycinate.

The Fundamental Difference: Molecular Binding

The core distinction between magnesium citrate and magnesium glycinate lies in what the magnesium ion is bound to. This binding molecule, known as a 'chelate', dictates how the body absorbs the magnesium and what primary benefits it offers.

Magnesium Citrate: The Digestive Aid

Magnesium citrate is a compound where magnesium is bound to citric acid, a naturally occurring substance found in citrus fruits. This particular combination results in a supplement with a well-known effect on the digestive system. Its primary use is as a remedy for occasional constipation.

Key functions of magnesium citrate:

  • Osmotic Effect: It draws water into the intestines, which helps to soften stool and promote bowel movements. This laxative property is why it's a common choice for quick digestive relief.
  • High Bioavailability: It is easily absorbed by the body, making it effective for increasing overall magnesium levels. However, its digestive impact makes it less suitable for long-term, high-dose use for general supplementation.
  • Electrolyte Restoration: Due to its role in fluid balance, it can be useful for replenishing electrolytes, especially after intense physical activity.

Magnesium Glycinate: The Calming Agent

Magnesium glycinate is a chelated form of magnesium bound to the amino acid glycine. Unlike citrate, its primary use is for its calming effects on the nervous system, not for digestive purposes. The presence of glycine plays a significant role in its benefits.

Key functions of magnesium glycinate:

  • Relaxation and Sleep: Glycine acts as an inhibitory neurotransmitter, helping to calm the brain and promote restful sleep.
  • Gentle on the Stomach: It is highly tolerable and less likely to cause the digestive discomfort or laxative effects associated with other forms of magnesium. This makes it a great option for individuals with sensitive digestive systems.
  • General Supplementation: Due to its excellent absorption and minimal side effects, it is a preferred choice for those seeking to supplement their daily magnesium intake without digestive issues.
  • Anxiety and Stress Support: The calming properties of both magnesium and glycine can help manage symptoms of anxiety and stress.

Comparison Table: Citrate vs. Glycinate

Feature Magnesium Citrate Magnesium Glycinate
Primary Use Occasional constipation, digestive health Relaxation, sleep, anxiety, general supplementation
Digestive Impact Has a laxative effect, can cause loose stools at high doses Gentle on the stomach, minimal digestive side effects
Associated Compound Citric Acid Glycine (amino acid)
Ideal Timing Can be taken in the morning for digestive regularity Often taken in the evening to promote sleep
Side Effects May cause loose stools, diarrhea, or cramping Generally well-tolerated with few side effects

How to Choose the Right Magnesium for You

Choosing between magnesium citrate and glycinate depends entirely on your specific health goals.

Choose Magnesium Citrate if you are seeking:

  • Relief from Constipation: It is the go-to choice for individuals needing a reliable, fast-acting solution for irregular bowel movements.
  • Digestive Support: If your primary concern is overall digestive health and regularity, citrate is the more direct option.

Choose Magnesium Glycinate if you are seeking:

  • Improved Sleep: For those who struggle with insomnia or poor sleep quality, the calming effect of glycine can be highly beneficial.
  • Stress and Anxiety Relief: The compound's ability to support the nervous system makes it a popular choice for managing daily stress.
  • Gentle Daily Supplementation: If you have a sensitive stomach or need long-term supplementation without the laxative side effects, glycinate is the better option.
  • Muscle Relaxation: For night-time leg cramps or general muscle tension, glycinate is effective and well-tolerated.

Combining Magnesium Supplements

Some people may find benefits from using both forms of magnesium. It is possible to strategically combine them to address different needs. For example, you might use magnesium citrate in the morning for digestive support and magnesium glycinate in the evening to aid sleep and relaxation. However, it is essential to monitor your total daily intake to avoid excessive magnesium, which could lead to loose stools even with the gentler glycinate form. Always consult a healthcare professional before combining supplements.

Conclusion: Making an Informed Choice

While both magnesium citrate and magnesium glycinate are highly bioavailable magnesium supplements, their distinct molecular structures lead to very different primary effects. Magnesium citrate is a powerful and effective osmotic laxative, best suited for short-term relief of constipation. Magnesium glycinate, on the other hand, is a gentle and calming supplement that supports relaxation, sleep, and reduces anxiety. Understanding these fundamental differences is key to selecting the right supplement for your individual health needs. Remember to always consult with a doctor or qualified healthcare provider before starting any new supplement regimen.

For more information on the various forms of magnesium and their applications, consider exploring resources from a trusted health authority, such as Verywell Health, a reputable online resource.

Frequently Asked Questions

No, magnesium glyphosate is a mistaken term. Glyphosate is an herbicide ingredient. The correct and beneficial supplement is magnesium glycinate.

Magnesium citrate is the better choice for constipation due to its osmotic effect, which draws water into the intestines and promotes bowel movements.

Magnesium glycinate is the superior option for sleep and relaxation because it is bound to the amino acid glycine, which has a calming effect on the brain.

Yes, many people take both for different benefits. For example, citrate in the morning for digestion and glycinate at night for sleep. However, monitor your intake to avoid adverse effects.

No, magnesium glycinate is known for being gentle on the stomach and is much less likely to cause digestive issues like diarrhea compared to magnesium citrate or oxide.

Magnesium citrate works as an osmotic laxative, meaning it pulls water into your intestines from the surrounding tissues. This softens the stool and increases bowel movements.

Both are considered highly bioavailable, but some studies suggest that chelated forms like glycinate may have slightly better absorption over the long term and are certainly better tolerated digestively.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.