What is zinc bisglycinate? Understanding a highly absorbable mineral

October 4, 2025 •

3 min read

According to the World Health Organization, two-thirds of the global population may suffer from moderate zinc deficiency. Understanding the different supplemental forms is crucial, which is why we explore what is zinc bisglycinate, a chelated mineral designed for superior absorption and less gastrointestinal distress.

Quick Summary

Zinc bisglycinate is a chelated mineral with two glycine molecules, providing enhanced bioavailability and better tolerability than many other forms. This superior absorption supports critical bodily functions, including immune response, skin health, and hormonal balance.

Key Points

Superior Absorption: The chelated form of zinc bisglycinate is more effectively absorbed by the body compared to other zinc salts.
Gentle on the Stomach: Its structure minimizes the gastrointestinal side effects, such as nausea, that are common with other zinc supplements.
Immune System Support: It helps maintain a healthy immune response by supporting the production of essential white blood cells.
Enhanced Bioavailability: The chelation process protects zinc from dietary inhibitors like phytates, ensuring higher bioavailability.
Supports Skin and Hormonal Health: Adequate zinc levels, boosted by bisglycinate, aid in wound healing, skin health, and testosterone production.
Minimal Interactions: It does not compete with other minerals like iron for absorption, promoting a better balance of nutrients.
Consult a Professional: Discussing supplementation with a healthcare provider is recommended.

What is zinc bisglycinate?

Zinc bisglycinate is a supplemental form of zinc where the zinc ion is bonded to two molecules of the amino acid glycine. This chelated structure makes it more easily absorbed by the body compared to non-chelated forms like zinc gluconate or sulfate. The two glycine molecules give it the name 'bisglycinate'. Being bound to an amino acid allows it to use amino acid absorption pathways, avoiding interference from dietary factors like phytates and competition with other minerals.

The chelation advantage

The chelated structure enhances bioavailability, meaning more zinc reaches the bloodstream. This structure also protects zinc from compounds in food that can inhibit absorption. Zinc bisglycinate is also known for its better tolerability, causing fewer gastrointestinal side effects like nausea compared to other forms.

Comparing different zinc supplements

The table below outlines the key differences between zinc bisglycinate and other common types.


Feature	Zinc Bisglycinate	Zinc Gluconate	Zinc Sulfate
Form	Chelated (zinc + 2 glycine)	Inorganic salt	Inorganic salt
Bioavailability	High; superior absorption shown in studies	Moderate; absorption can be inconsistent	Low; relatively poor absorption
GI Tolerability	High; gentle on the stomach and minimizes nausea	Moderate; more likely to cause stomach upset	Low; frequently causes stomach upset
Interaction with Food	Minimal interference from dietary factors like phytates	Absorption can be reduced by certain foods	Absorption is highly affected by food
Application	Ideal for high bioavailability needs and sensitive individuals	Common for general supplementation	Often used in lozenges or topical treatments

Health benefits of zinc supplementation

Zinc is crucial for over 300 enzyme functions. Supplementing with a bioavailable form like zinc bisglycinate supports these processes.

Immune system support

Zinc is vital for immune function, supporting the production of white blood cells that defend against pathogens. It may also help reduce the duration of cold symptoms. The enhanced absorption of zinc bisglycinate supports these benefits.

Skin health and wound healing

Zinc is essential for tissue repair, collagen production, and wound healing. Adequate levels are also associated with improved acne outcomes.

Hormonal balance

Zinc is important for testosterone production, particularly in men. Deficiency is linked to lower testosterone levels. Supplementation can help maintain healthy hormone levels.

Antioxidant and cognitive function

Zinc acts as an antioxidant, helping to reduce oxidative stress. It also supports cognitive functions like memory and mood.

Considerations for taking zinc bisglycinate

Taking any supplement should be done responsibly and in consultation with a healthcare professional to determine appropriate use, as individual needs and the form of zinc can affect absorption and potential side effects. It is important to ensure supplements are of high quality. High amounts or long-term use can affect the absorption of other minerals like copper, so discussing this with a doctor is recommended.

Conclusion

Zinc bisglycinate's chelated form offers superior absorption and better digestive tolerance compared to other zinc supplements. It is an excellent choice for those seeking to effectively support immune function, skin health, and overall well-being, especially for individuals with sensitive digestive systems or those with dietary restrictions that may hinder mineral absorption.

For more information on the science behind mineral chelation, you can consult sources like Albion Minerals.

Frequently Asked Questions

Zinc bisglycinate is a chelated form, meaning the zinc is bound to two glycine molecules. This structure is more bioavailable, better absorbed, and gentler on the stomach compared to non-chelated forms like zinc gluconate or sulfate.

Yes, for supplemental purposes, zinc glycinate and zinc bisglycinate refer to the same compound. The term 'bis' (meaning two) is often added for chemical clarity to emphasize the presence of two glycine molecules.

Zinc bisglycinate is known for being gentler on the digestive system than other forms of zinc. While some people may still experience mild effects, it is less likely to cause nausea or stomach irritation, especially when taken with food.

Individual needs for zinc can vary. It is recommended to consult a healthcare professional for personalized guidance to ensure safe and effective supplementation.

Unlike other zinc salts, the chelated structure of zinc bisglycinate protects it from dietary inhibitors like phytates found in many plant foods. This means its absorption is less affected by what you eat.

Chelated minerals, including zinc bisglycinate, are bound to amino acids. This structure allows them to be absorbed more efficiently, protects them from dietary interference, and often improves tolerability.

Individuals with known zinc deficiencies, people with sensitive stomachs, vegans, and those with certain gastrointestinal conditions may particularly benefit from the high bioavailability and gentle nature of zinc bisglycinate.