What Peptides Does Joe Rogan Take for Longevity and Healing?

November 18, 2025 •

3 min read

Joe Rogan, a prominent podcaster and health enthusiast, has openly discussed his use of peptides on numerous occasions. He regularly discusses his approach to biohacking and longevity, often bringing up specific peptides he takes to help with tissue regeneration, recovery, and overall performance.

Quick Summary

Joe Rogan publicly shares his use of specific peptides, primarily BPC-157, Ipamorelin, and Thymosin (TB-500). These are used to support healing, growth hormone production, and anti-inflammatory processes. His regimen is part of a broader health strategy that includes testosterone replacement therapy and supplements.

Key Points

BPC-157: Joe Rogan mentions taking this peptide for its powerful wound-healing and regenerative properties, which he credits with helping heal his elbow tendonitis.
Ipamorelin: He uses Ipamorelin as a growth hormone secretagogue to stimulate the pituitary gland, promoting muscle growth, fat loss, and better sleep.
Thymosin (TB-500): Often used alongside BPC-157, Thymosin is taken for its ability to enhance tissue repair and modulate the immune system.
Not a standalone solution: Rogan emphasizes that peptides are part of a larger health optimization regimen that includes Testosterone Replacement Therapy (TRT), specific diet, and rigorous exercise.
Experimental Nature: The field of peptide therapy is considered experimental by many health experts, and their use requires caution and professional guidance.

Joe Rogan's Peptide Stack: An Overview

Joe Rogan's pursuit of peak physical and mental performance has led him to explore various biohacking strategies, with peptide therapy being a significant component. The peptides he has specifically mentioned on his podcast, The Joe Rogan Experience, include BPC-157, Ipamorelin, and Thymosin (often used in the form of TB-500). Rogan emphasizes that these substances help the body produce hormones it made naturally in youth, aiding in recovery and regeneration. It's crucial to remember that this is an experimental and unregulated area of health, and any regimen should be undertaken with professional medical guidance.

BPC-157: The Healing Compound

BPC-157, or Body Protection Compound 157, is perhaps the most famous peptide Rogan has mentioned. Derived from a protein found in the stomach, BPC-157 is known for its regenerative and wound-healing properties.

Injury Recovery: Rogan has openly discussed using BPC-157 to help with injuries, such as elbow tendonitis, and has noted rapid recovery times. Athletes frequently use this peptide to speed up the healing of tendons, ligaments, and muscle tissue.
Anti-inflammatory Effects: BPC-157 has anti-inflammatory properties that contribute to its healing capabilities by reducing swelling and discomfort.
Gut Health: The peptide is also known to promote gut health and protect against ulcers due to its origin in gastric protein.

Ipamorelin: The Growth Hormone Secretagogue

Ipamorelin is another peptide in Rogan's arsenal, which is a selective growth hormone secretagogue. This means it stimulates the pituitary gland to release growth hormone without the adverse side effects associated with other growth hormone-releasing compounds, such as increased cortisol.

Fat Loss and Muscle Growth: By boosting growth hormone levels, Ipamorelin can help with lean muscle growth and fat metabolism.
Improved Sleep: Elevated growth hormone levels can contribute to better sleep quality, which is crucial for overall recovery and well-being.
Anti-Aging: As growth hormone production naturally declines with age, Ipamorelin helps counteract some of these effects.

Thymosin (TB-500): The Tissue Repairer

Thymosin, specifically TB-500, is a synthetic version of the naturally occurring peptide Thymosin Beta-4. It is primarily used for its potent regenerative and healing properties and is often used alongside BPC-157.

Cell Repair: TB-500 helps regulate actin, a protein essential for cell structure and movement, which aids in tissue repair.
Injury Healing: Like BPC-157, TB-500 accelerates the healing of damaged tissue and can help strengthen tendons and ligaments.
Immune System Support: Thymosin plays a role in stimulating T-cell production, which is a key part of the immune system.

A Comparison of Joe Rogan's Peptides


Feature	BPC-157	Ipamorelin	Thymosin (TB-500)
Primary Function	Healing and regeneration	Growth hormone release	Tissue repair and immune modulation
Mechanism	Promotes cellular regeneration	Stimulates pituitary gland	Regulates actin for cell repair
Key Benefits	Injury recovery, reduced inflammation, gut health	Muscle growth, fat loss, improved sleep	Accelerated healing, immune support
Best Used For	Targeted injury recovery	Systemic anti-aging and performance enhancement	Broad tissue and wound healing
Frequently Stacked With	TB-500	CJC-1295	BPC-157

The Broader Context of Rogan's Regimen

Peptides do not exist in a vacuum within Rogan's health and wellness routine. He openly combines them with other treatments and a strict lifestyle. For example, he has been using Testosterone Replacement Therapy (TRT) since his 40s to address declining testosterone levels. This, along with a primarily carnivorous diet, rigorous exercise, and supplementation with items like Alpha Brain and NAD+ precursors, forms a comprehensive approach to combating aging. Rogan also advocates for a holistic perspective, emphasizing that these substances are most effective when combined with a disciplined lifestyle. The landscape of peptide regulation is complex, and the FDA does not approve many of the peptides used for wellness purposes. Therefore, individuals must be extremely cautious and work with qualified medical professionals if they choose to explore this path. For more insight on peptides in general, the National Institutes of Health provides information on the research and clinical use of various peptides.

Conclusion

While the specific combinations and dosages may change, what peptides Joe Rogan takes are consistently reported to include BPC-157 for targeted healing, Ipamorelin for growth hormone enhancement, and Thymosin (TB-500) for overall tissue repair and immune support. His experience highlights the potential of peptides within a broader biohacking strategy, but also underscores the importance of a balanced lifestyle and professional medical oversight. Anyone considering a similar path should conduct thorough research and consult with a healthcare professional to ensure safety and appropriateness. The use of peptides is an evolving field, and a cautious, informed approach is essential.

Learn more about peptide research from the National Institutes of Health.

Frequently Asked Questions

Yes, Joe Rogan has been open about his use of Testosterone Replacement Therapy (TRT), which he started in his early 40s to counteract the natural decline in testosterone levels.

BPC-157 is primarily used for its regenerative and healing properties, which can help accelerate the recovery of muscles, tendons, ligaments, and gastrointestinal tissues.

Ipamorelin is a growth hormone secretagogue, a peptide that stimulates the body's natural production of growth hormone. It is known for its ability to promote muscle growth, fat loss, and improved sleep.

TB-500 (Thymosin) is frequently stacked with BPC-157 because they have synergistic effects, both working to promote healing and tissue regeneration from different angles.

While many peptides occur naturally in the body, the use of synthetic peptides for therapy is largely unregulated. Their long-term safety is still under investigation, and they should only be used under the guidance of a qualified medical professional.

Joe Rogan works with doctors and medical professionals who prescribe and oversee his peptide and hormone therapy regimens. He strongly advises against self-administering without proper medical supervision.

Peptides can offer a wide range of benefits depending on the specific type used. These can include enhanced recovery, increased muscle mass, fat loss, anti-inflammatory effects, improved immune function, and anti-aging properties.