What Supplement Has DPA in It? Decoding the Omega-3 Family

January 14, 2026 •

4 min read

Recent research has highlighted Docosapentaenoic Acid (DPA) as a crucial, yet often overlooked, member of the omega-3 family, with significant cardiovascular and anti-inflammatory benefits. A growing number of consumers are now asking: what supplement has DPA in it? The answer lies primarily in specific, high-quality fish oil and algal oil products, though not all omega-3 supplements are created equal in their DPA content.

Quick Summary

DPA, a vital omega-3 fatty acid, is primarily found in specialized fish oil, seal oil, and algal oil supplements. Some products are specifically formulated to be high in DPA, recognizing its cardiovascular and anti-inflammatory benefits that complement EPA and DHA. Consumers should check product labels for transparency regarding DPA content.

Key Points

DPA is a crucial omega-3 fatty acid: Docosapentaenoic Acid (DPA) offers unique cardiovascular and anti-inflammatory benefits beyond EPA and DHA.
Not all omega-3 supplements contain significant DPA: Traditional purification processes can remove DPA, so it's important to check product labels specifically for DPA content.
High-DPA fish oil is a reliable source: Look for supplements explicitly labeled as 'high-DPA fish oil,' often derived from fish like menhaden.
Seal oil is exceptionally rich in DPA: Brands like DPA Gold offer supplements from seal oil, which is a naturally high source of Docosapentaenoic Acid.
Algal oil can be a plant-based DPA option: Certain algal oil supplements are formulated to provide DPA, making them suitable for vegetarians and vegans.
ALA conversion is inefficient for DPA: Relying solely on plant-based ALA from sources like flaxseed will likely result in a low DPA intake.
Check for transparency and purity: Choose supplements with clear DPA amounts on the label, and ensure they are tested for purity and preferably in triglyceride form.

The Importance of DPA in the Omega-3 Spectrum

For years, omega-3 discussions have centered on two key players: Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA). However, Docosapentaenoic Acid (DPA), a longer-chain omega-3, is gaining recognition for its distinct health benefits. Acting as a metabolic intermediary between EPA and DHA, DPA can be converted to either fatty acid, but it also possesses unique properties that enhance cardiovascular and anti-inflammatory processes. Research indicates that DPA may be more potent at reducing inflammation than EPA and has a longer retention time in the bloodstream, increasing its bioavailability. This has led to a greater interest in finding reliable sources of this nutrient.

Fish Oil: A Primary Source of DPA

Fish oil supplements are the most common source of DPA. However, standard fish oils, particularly those that have undergone extensive processing, often contain significantly lower levels of DPA compared to their natural source. Traditional purification methods like distillation can inadvertently remove DPA, leading to a focus on maximizing EPA and DHA at the expense of other important fatty acids.

To find a fish oil supplement with DPA, look for products that explicitly mention DPA on the label. Some manufacturers are now specifically formulating their supplements to be 'high-DPA fish oil'.

Common Fish Oil Sources with DPA:

Anchovy, sardine, and mackerel oils
Menhaden fish oil
Wild Alaskan Pollock oil

Specialized DPA Supplements

Beyond standard fish oil, a new wave of specialized supplements has entered the market to deliver higher concentrations of DPA. These products are developed by companies that recognize DPA's emerging importance.

Examples of DPA-Rich Supplements:

High-DPA fish oil blends: Some brands, like Swanson and PhysioTru, offer products specifically marketed as containing elevated levels of DPA alongside EPA and DHA.
Seal Oil: While less common in Western diets, seal oil is one of the richest natural sources of DPA. Brands like DPA Gold specialize in these seal oil supplements.
Algal Oil: A plant-based alternative, algal oil is a viable option for vegetarians or those who avoid fish. Certain algal oil supplements can provide a good source of DPA and other omega-3s.

The Role of ALA Conversion

For those who prefer plant-based diets, another route to obtaining DPA is through the conversion of Alpha-linolenic Acid (ALA), a plant-based omega-3 found in sources like flaxseed and chia seeds. The body converts ALA into EPA and then, to a lesser extent, into DPA and DHA. This conversion process is, however, highly inefficient, and relying on ALA alone may not provide sufficient DPA levels.

What to Look for When Choosing a Supplement with DPA

When selecting an omega-3 supplement, consider the following points to ensure you are getting a reliable dose of DPA:

Explicit Labeling: The supplement facts label should clearly state the amount of DPA per serving, not just the total omega-3s.
Source: Look for supplements derived from specific sources known to be higher in DPA, such as menhaden fish oil, or specialty seal oil.
Purity and Processing: Search for products that are molecularly distilled or purified to remove contaminants while preserving the full spectrum of omega-3s. High-quality brands will often state their purification methods and third-party testing results.
Triglyceride Form: Omega-3s in their natural triglyceride form are generally better absorbed by the body than ethyl esters.

Comparison Table: DPA Sources


Feature	Fish Oil	Algal Oil	Seal Oil	ALA (from plants)
Primary DPA Source	Anchovy, Sardine, Mackerel, Menhaden	Algae	Seals	Inefficient Conversion
DPA Concentration	Varies widely; some products are 'High-DPA'	Can be a good source depending on formulation	Naturally one of the richest sources	Low, due to poor conversion rate
EPA/DHA Presence	Present; usually higher than DPA	Present; ratio varies	Also present in significant amounts	Converted from ALA, but inefficiently
Best for	Most people seeking a balanced omega-3 profile	Vegetarians, vegans	Those seeking highest natural DPA source	General omega-3 support, not targeted DPA
Sustainability	Varies by brand; look for certifications like MSC	Often a sustainable, renewable source	Less common; depends on regulation

Conclusion

While DPA may not be as well-known as EPA and DHA, its unique properties make it a valuable component of a comprehensive omega-3 regimen. The question of what supplement has DPA in it can be answered by looking beyond standard fish oil products to specialized high-DPA fish oils, seal oil, and certain algal oil formulations. By paying close attention to product labels and understanding the different sources, consumers can effectively choose a supplement that delivers this crucial, heart-healthy fatty acid. For those relying on plant-based ALA, it is important to be aware of the body's limited conversion efficiency and potentially seek out specialized algal options.

Frequently Asked Questions

DPA is important because it acts as an intermediate between EPA and DHA. It also possesses potent anti-inflammatory properties, can improve vascular health, and may contribute to better cognitive function.

Standard fish oil supplements typically contain low levels of DPA because it is often removed during modern processing and distillation methods designed to concentrate EPA and DHA.

While DPA is found naturally in fatty fish like salmon, mackerel, and sardines, obtaining high concentrations solely through diet can be challenging. This is why supplements formulated with higher DPA content are available.

All three are omega-3 fatty acids. DPA acts as a 'reservoir' for the body, which can convert it into EPA or DHA as needed. It also has its own unique benefits, such as superior anti-inflammatory and cardiovascular effects.

Yes, for vegetarians and vegans, algal oil supplements can be a source of DPA. Algae are a primary food source for many fatty fish, making it a viable plant-based alternative.

Look for supplements with explicit DPA content listed on the label, sourced from high-quality fish oil (like menhaden), seal oil, or algal oil. Verify that the product is molecularly distilled for purity and ideally in the more bioavailable triglyceride form.

Official daily dosage recommendations are not yet established for DPA alone, unlike for combined EPA and DHA. Research is still emerging on optimal DPA intake. It is best to follow manufacturer guidelines or consult a healthcare provider.