Who should not take Ryze mushroom coffee?: Important Health Considerations

October 7, 2025 •

4 min read

While Ryze mushroom coffee is celebrated for its adaptogenic properties and lower caffeine content, it is not suitable for everyone. Certain pre-existing health conditions, medications, and sensitivities necessitate caution or complete avoidance of the beverage to prevent adverse reactions and health complications.

Quick Summary

This article outlines the individuals who should avoid or use caution when consuming Ryze mushroom coffee due to allergies, medical conditions like kidney or liver issues, and potential interactions with certain medications. It emphasizes the importance of consulting a healthcare provider before adding the beverage to your diet.

Key Points

Pregnancy and Breastfeeding: Limited research means it is best for expectant and nursing mothers to avoid Ryze mushroom coffee.
Kidney Health Concerns: Individuals with a history of kidney stones or kidney disease should be cautious due to the high oxalate content of Chaga mushrooms.
Medication Interactions: Mushrooms like Reishi can interact with medications for blood pressure, diabetes, and blood thinners, increasing health risks.
Fungi Allergies and Sensitivity: Anyone with a mushroom allergy or general fungal sensitivity should avoid Ryze to prevent allergic reactions.
Liver and Digestive Issues: Those with pre-existing liver conditions or sensitive digestive systems may experience adverse effects like liver toxicity or gastrointestinal discomfort.
Autoimmune Conditions: Caution is advised for individuals with autoimmune disorders, as medicinal mushrooms can have immunomodulatory effects that may not be beneficial.

Understanding the Ingredients in Ryze Mushroom Coffee

Ryze mushroom coffee is a blend of organic coffee and several medicinal mushrooms, including Lion's Mane, Cordyceps, Reishi, Chaga, Shiitake, and King Trumpet. Each of these mushrooms contains unique bioactive compounds, such as beta-glucans, triterpenoids, and polysaccharides, which are believed to offer various health benefits. While these ingredients are generally safe for most people, their potency can pose risks for specific groups. The coffee's adaptogenic properties, intended to help the body manage stress, can also interact with bodily systems in unintended ways. For instance, certain mushrooms may influence blood pressure, blood sugar, and immune function, making it crucial to understand the potential effects before consumption.

Specific Health Conditions Requiring Caution or Avoidance

Several health conditions warrant a discussion with a healthcare provider or complete avoidance of Ryze mushroom coffee. The blend's potent ingredients can exacerbate symptoms or interfere with existing treatment plans.

Kidney and Liver Conditions

Individuals with a history of kidney disease or kidney stones should be particularly careful. The Chaga mushroom, a key ingredient in Ryze, is high in oxalates. Consuming large amounts of oxalates can increase the risk of kidney stone formation. In rare cases, long-term overconsumption of Chaga has been linked to oxalate-induced kidney disease. Similarly, excessive consumption of Reishi mushrooms has been associated with liver toxicity, making it a concern for those with pre-existing liver conditions.

Digestive Sensitivities and Irritable Bowel Syndrome (IBS)

For some people, the extracts in mushroom coffee can be difficult to digest, leading to gastrointestinal discomfort. Symptoms may include bloating, gas, nausea, and diarrhea. Individuals with conditions like IBS may be more susceptible to these side effects due to their sensitive digestive systems.

Diabetes and Blood Sugar Regulation

Ryze contains mushrooms like Cordyceps and Reishi that have been shown to affect blood sugar levels. While this can be beneficial for some, it poses a risk for individuals with diabetes, as it could interfere with their medication and make blood sugar management unpredictable. Patients with diabetes should consult their doctor before using any product containing medicinal mushrooms.

Blood Pressure Issues

Certain mushrooms in the blend, such as Reishi, may have a blood-pressure-lowering effect. This can be a concern for individuals who already have low blood pressure or those taking medication to manage their blood pressure.

Risks for Pregnant and Breastfeeding Women

Health experts strongly advise against consuming Ryze mushroom coffee for pregnant and breastfeeding women. The primary reason for this is the lack of robust human clinical trials to confirm the safety of medicinal mushroom extracts during these sensitive periods. While the caffeine content is lower, the effects of adaptogenic mushrooms on a developing fetus or infant are not well-understood. It is always best to err on the side of caution and avoid these products.

Mushroom Allergies and Fungal Sensitivity

An obvious contraindication is a known allergy to mushrooms or fungi. Allergic reactions can range from mild symptoms like skin rashes and dizziness to more severe reactions. Even without a diagnosed allergy, some individuals with mold sensitivity or candida overgrowth may experience adverse reactions due to the fungal nature of the ingredients. Symptoms can include fatigue, brain fog, and inflammation.

Drug Interactions and Other Considerations

The bioactive compounds in medicinal mushrooms can interact with a variety of medications, altering their effectiveness or causing adverse side effects.

Potential Drug Interactions

Blood Thinners (Anticoagulants): Reishi mushrooms can affect blood clotting, increasing the risk of bleeding when combined with anticoagulant medications.
Immunosuppressants: Certain mushrooms, including Chaga and Reishi, may interact with immunosuppressants, which could be problematic for transplant recipients or individuals with specific autoimmune conditions.
Diabetes Medication: As mentioned, the effect on blood sugar can interfere with diabetes management.
Antipsychotics and SSRIs: The caffeine content, even at lower levels, can interact with certain psychiatric medications.

Autoimmune Conditions

While some sources suggest that the immunomodulatory properties of mushrooms could help with autoimmune diseases, other experts recommend caution. The complex nature of autoimmune disorders means that any substance affecting the immune system should be taken under strict medical supervision. There have been reports of mushroom supplements triggering a flare-up of autoimmune conditions in some patients.

Ryze Mushroom Coffee vs. Regular Coffee: A Comparison

To highlight the key differences, here is a comparison table outlining Ryze mushroom coffee and traditional regular coffee, considering the health implications for sensitive individuals.


Feature	Ryze Mushroom Coffee	Regular Coffee
Caffeine Content	Typically lower (around 48 mg)	Higher (around 95 mg)
Key Ingredients	Coffee, Cordyceps, Lion's Mane, Reishi, Chaga, etc.	Roasted coffee beans
Adaptogens	Contains adaptogenic mushrooms	None
Kidney Risk (Oxalates)	Higher risk due to Chaga content	No increased risk from oxalates
Drug Interactions	Significant potential for interactions due to medicinal mushrooms	Potential for caffeine interactions, fewer overall
Allergy Risk	Higher risk for those with mushroom/fungi allergies	Lower risk; primarily sensitivity to caffeine

Conclusion: Prioritizing Your Health

While the marketing of Ryze mushroom coffee highlights its potential benefits, it's essential to recognize that not all wellness products are universally safe. The potent combination of medicinal mushrooms can pose significant risks for individuals with specific health conditions, allergies, or those taking certain medications. Pregnant and breastfeeding women, in particular, should avoid it entirely due to the lack of safety data. Before incorporating any new supplement or functional beverage into your routine, especially one with strong bioactive compounds, it is crucial to consult with a healthcare provider. A medical professional can assess your individual health profile and provide personalized advice to ensure your safety and well-being. Ultimately, informed choices are the cornerstone of a balanced and healthy nutrition diet.

For more information on drug interactions with herbal supplements, consult authoritative sources like MedlinePlus.

Frequently Asked Questions

No, it is strongly recommended that pregnant women avoid Ryze mushroom coffee. There is limited scientific research on the effects of medicinal mushrooms on a developing fetus, so it is safest to avoid it entirely.

Yes, individuals with kidney issues or a history of kidney stones should be cautious. The Chaga mushroom in Ryze contains high levels of oxalates, which can increase the risk of stone formation.

It can. Certain mushrooms in Ryze, like Reishi and Chaga, can interact with medications for blood pressure, diabetes, and blood thinners. Always consult your doctor before consuming.

People with autoimmune diseases should be cautious and consult a healthcare provider. While some mushrooms have immunomodulatory effects, they could also potentially trigger a flare-up of the condition.

If you have a known allergy to mushrooms or fungi, you should not consume Ryze mushroom coffee, as it contains potent mushroom extracts that can trigger an allergic reaction.

Ryze typically has a lower caffeine content (around 48 mg per serving) compared to regular coffee. However, caffeine-sensitive individuals should still be mindful of their intake.

Excessive consumption of Reishi mushrooms, a Ryze ingredient, has been associated with liver toxicity in some cases. Those with pre-existing liver conditions should consult a doctor.