Discovering What CoQ10 Is Made In The USA

January 6, 2026 •

3 min read

Kaneka Nutrients proudly manufactures the only CoQ10 ingredient produced in the USA through yeast fermentation. This ingredient, known as Kaneka Q10® and its active form Kaneka Ubiquinol®, is utilized by many supplement brands that can claim to be Made in the USA.

Quick Summary

An overview of CoQ10 supplements manufactured in the USA, focusing on the primary ingredient source from Kaneka and how this affects brand-level products and quality.

Key Points

Kaneka Nutrients is the Sole US Ingredient Manufacturer: Kaneka produces the only CoQ10 and Ubiquinol ingredients manufactured in the USA, at its Texas facility.
USA Manufacturing Does Not Guarantee USA-Sourced Ingredients: Many brands can claim 'Made in the USA' for their final product, even if the raw CoQ10 is imported. Kaneka-based products offer a fully domestic supply chain.
Third-Party Verification is Crucial: Look for supplements with quality certifications from organizations like USP or NSF to independently verify content and purity.
Ubiquinol vs. Ubiquinone: Both are forms of CoQ10. Brands like Qunol offer both, with Ubiquinol being the active, more easily absorbed form.
Reputable Brands Include Qunol, Nature Made, and Purely Holistic: These companies are noted for using US manufacturing and adhering to quality standards.
Ingredient Source Impacts Quality and Bioavailability: CoQ10 from yeast fermentation (Kaneka) is bioidentical to the body's natural form, offering higher purity than synthetically produced options.

Sourcing the Core Ingredient: Kaneka Q10

While many supplement companies might manufacture their final products domestically, the true source of the active ingredient is a key differentiator. The vast majority of CoQ10 raw material is sourced internationally. However, one American company, Kaneka Nutrients, stands out by producing its proprietary CoQ10 ingredients, Kaneka Q10® and Kaneka Ubiquinol®, in its Houston, Texas facility. This provides a unique advantage for brands that prioritize a fully domestic supply chain.

The Kaneka Fermentation Process

Kaneka's process for creating CoQ10 uses yeast fermentation, a method that produces a CoQ10 molecule with an all-trans configuration. This structure is bioidentical to the CoQ10 naturally produced by the human body, which is a significant factor in its effectiveness and purity. This contrasts with CoQ10 produced through chemical synthesis, which can leave impurities. For consumers, this means a trusted ingredient backed by decades of research and strict quality control standards.

Leading CoQ10 Supplement Brands That Utilize USA Manufacturing

Numerous supplement brands use Kaneka's USA-made ingredients and/or manufacture their final products in the United States. When searching for a quality supplement, it is crucial to look for brands that not only produce their products domestically but also use high-quality, reputable raw materials.

Here is a list of companies and brands that have been identified in search results as utilizing USA manufacturing for CoQ10 supplements or their ingredients:

Qunol: The company website states that its products, including Qunol Ultra and Qunol Mega, are manufactured in the United States.
Nature Made: This brand offers CoQ10 supplements that carry the USP Verified mark, ensuring purity and potency, and are manufactured with high standards.
Purely Holistic: Specifically claims to use USA manufacturing for its CoQ10 supplements to ensure quality control.
Kirkland Signature: A common name found in product comparisons, with some versions of its CoQ10 supplements receiving high marks for quality.
NOW Foods: This brand, based in Illinois, manufactures a variety of supplements and performs its own quality testing.
Life Extension: Offers CoQ10 supplements and has a positive reputation for quality and efficacy.

Importance of Third-Party Quality Verification

Regardless of where a supplement is manufactured, third-party verification is the gold standard for ensuring quality, potency, and purity. Organizations like the United States Pharmacopeia (USP) and NSF International provide crucial oversight. A supplement that carries a certification mark from one of these organizations has been independently tested to confirm that its contents match the label and it is free from harmful contaminants. For example, Nature Made CoQ10 is USP verified, and some Momentous and Nordic Naturals products are NSF Certified for Sport®. This extra layer of accountability is a vital consideration for consumers seeking a trustworthy product.

Comparing USA-Made CoQ10 Supplements


Feature	Kaneka (Ingredient)	Nature Made	Qunol	Purely Holistic
Origin	Ingredient manufactured in Houston, TX	Finished product manufactured in USA	Finished product manufactured in USA	Finished product manufactured in USA
Verification	Proprietary process, ingredient used in verified products	USP Verified	Proprietary absorption formula	Claims GMP compliance
Key Claim	Bioidentical form, superior purity	Guaranteed quality standards	Better absorption	Natural ingredients, no fillers
Form	Ubiquinone (Q10®), Ubiquinol (QH®)	Softgels (ubiquinone)	Softgels, liquid (ubiquinone & ubiquinol)	Softgels (ubiquinone)

Conclusion

When seeking to know what CoQ10 is made in the USA, it's essential to understand that this can refer to either the raw ingredient or the final supplement product. The primary US manufacturer of the CoQ10 ingredient itself is Kaneka Nutrients. Numerous brands, including Qunol, Nature Made, and Purely Holistic, utilize American manufacturing facilities. Prioritizing supplements that carry third-party quality certifications, such as those from USP or NSF, is the best practice for ensuring you receive a high-quality, pure, and potent product. Always read the label and do your own research to confirm the manufacturing processes and certifications of your chosen brand. For more information, the ConsumerLab.com guide to CoQ10 supplements is an excellent resource for independent reviews.

Frequently Asked Questions

Brands like Qunol, Nature Made, and Purely Holistic state that their products are manufactured in the USA. Kaneka Nutrients is also a key US-based manufacturer of the raw CoQ10 ingredient used by many supplement companies.

No. A product labeled 'Made in the USA' means the final product was packaged or processed in the country. The raw CoQ10 ingredient may be sourced internationally. To ensure the ingredient is also American, you should look for products that specifically mention using Kaneka Q10® or Kaneka Ubiquinol®, which is made in Texas.

Check for third-party certifications from organizations such as USP (U.S. Pharmacopeia) or NSF International. These verifications ensure the supplement's ingredients, potency, and purity have been independently tested.

Kaneka Q10® is the oxidized form of CoQ10, also known as ubiquinone. Kaneka Ubiquinol® is the active, antioxidant form that is more easily absorbed by the body. Many supplement brands offer one or both forms.

No, while Kaneka is the sole US manufacturer of the raw CoQ10 ingredient, not all brands that manufacture their products in the US use it. Some brands may import their raw CoQ10 material and perform the final production steps domestically.

Fermentation, as used by Kaneka, is generally considered superior because it produces a bioidentical CoQ10 molecule (all-trans configuration) with higher purity and fewer impurities than CoQ10 produced through chemical synthesis.

Qunol is manufactured in the United States, but their ingredient sourcing is not explicitly stated as solely from Kaneka. Qunol emphasizes its proprietary water and fat-soluble absorption formula, and while it's a USA-made product, the raw ingredient's origin isn't guaranteed to be domestic.