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Do Some Wines Make You Feel Worse Than Others?

4 min read

According to a 2023 study published in Scientific Reports, a flavonoid called quercetin found in red wine can block an enzyme crucial for alcohol metabolism, causing a buildup of toxins that make some people feel worse. This provides a scientific basis for why some wines make you feel worse than others.

Quick Summary

The severity of wine's aftereffects varies based on factors like congeners, histamines, tannins, and sugar content. Red wines often have higher levels of compounds that can trigger more intense reactions, including headaches and hangovers, compared to many white wines.

Key Points

  • Congeners are key culprits: Darker, more heavily aged wines like red wine and brandy contain more congeners, byproducts of fermentation linked to more severe hangovers.

  • Red wine is higher in histamines: Red wine, especially those undergoing malolactic fermentation, can contain higher levels of histamines, which trigger allergy-like symptoms in sensitive individuals.

  • Tannins can trigger headaches: Tannins, found in grape skins, can cause headaches in some people by affecting serotonin levels. Reds are generally higher in tannins than whites.

  • Sulfites are often misunderstood: Sulfites are preservatives, but they are not the primary cause of headaches for most people. True sensitivity is rare and usually causes respiratory or skin reactions.

  • Sugar exacerbates dehydration: Sweeter wines have higher sugar content, which worsens dehydration and contributes to more intense hangovers.

  • Organic isn't a silver bullet: Organic wines may have fewer additives, but they can still contain naturally occurring histamines and tannins that affect sensitive people.

  • Individual reactions vary: Your personal tolerance to different compounds, hydration level, and genetic factors all play a role in how a wine will make you feel.

In This Article

The Science Behind Your Wine Woes

Many people notice that different types of wine affect them differently. This isn't just a matter of alcohol content; the complex chemistry of wine includes various compounds that can trigger unpleasant reactions. From the natural byproducts of fermentation to additives, understanding these components is key to figuring out why some wines leave you feeling worse.

Congeners: The Darker Side of Wine

Congeners are chemical byproducts of the fermentation process that give alcoholic beverages their distinctive flavor, aroma, and color. Darker drinks, such as red wine, have significantly higher levels of congeners than lighter beverages like white wine or vodka. Studies have shown that consuming drinks with more congeners can lead to more severe hangovers because the body has to work harder to process both the alcohol and these extra compounds. Specific congeners like acetaldehyde, a known toxin, are particularly implicated in headaches and other hangover symptoms.

Histamines and Your Immune Response

Histamines are compounds that play a role in your immune system, triggering responses that can cause allergy-like symptoms such as sneezing, hives, or headaches. Histamine is a natural byproduct of wine fermentation, and levels are significantly higher in red wine than in white wine, partly due to the extended skin contact and malolactic fermentation common in red wine production. For individuals with histamine intolerance, drinking red wine can overwhelm the body's ability to break down histamine, leading to symptoms like flushing, nasal congestion, and headaches. Taking an antihistamine before drinking has been suggested to help some sensitive individuals.

Tannins: A Pucker with a Price?

Tannins are naturally occurring polyphenols found in grape skins, seeds, and stems, and they are responsible for the dry, bitter, and astringent sensation in many red wines. Because red wine is fermented with the grape skins, it contains significantly more tannins than white wine, which is pressed before fermentation. Some research suggests that tannins can trigger headaches in susceptible people by influencing serotonin levels in the brain. If you also get headaches from other tannin-rich foods like dark chocolate or tea, this may be your culprit.

The Truth About Sulfites

Sulfites, or sulfur dioxide, are used as a preservative in winemaking to prevent oxidation and bacterial spoilage. While often blamed for wine headaches, sulfites are unlikely to be the cause unless you have a true sensitivity. A sensitivity, which affects less than 1% of the population (many asthmatics), typically manifests as respiratory issues or hives, not headaches. In fact, red wines often contain lower levels of added sulfites than white wines because their tannins act as natural preservatives.

Sugar and Dehydration

Sweet wines and sparkling wines, like Prosecco, often have higher levels of residual sugar. The body needs additional water to metabolize this sugar, which exacerbates dehydration already caused by the alcohol. This can lead to more severe hangovers characterized by headaches, fatigue, and nausea. The bubbles in sparkling wine also accelerate the absorption of alcohol into your bloodstream, causing a more rapid onset of symptoms.

Comparison: Red Wine vs. White Wine

Understanding the fundamental differences between red and white wines can help explain why they affect people differently. The table below summarizes the key compounds often associated with adverse reactions.

Feature Red Wine White Wine
Congeners High (from skins and aging) Low (less processing)
Histamines High (from malolactic fermentation) Low (malolactic fermentation often skipped)
Tannins High (from skins, seeds, and stems) Very Low (fermented without skins)
Typical Added Sulfites Lower (tannins act as natural preservatives) Higher (less natural protection from oxidation)
Quercetin High (from grape skins, sunlight exposure) None to very low

Strategies for a More Enjoyable Experience

If you find that certain wines make you feel unwell, you have options beyond simply giving up. Experimentation and mindful drinking can help you find wines that agree with your body.

Here are some tips to consider:

  • Choose Lighter Wines: Opt for lighter-bodied red wines (like Pinot Noir) or young white wines, which generally have lower levels of congeners, histamines, and tannins.
  • Seek Dryness: Choose drier wines with lower residual sugar content to minimize dehydration and blood sugar fluctuations.
  • Consider Organic or Natural Wines: These wines often contain fewer additives, including lower levels of added sulfites, though they may not be entirely sulfite-free due to natural fermentation.
  • Explore Low-Histamine Options: Some winemakers produce lab-tested, low-histamine wines, though they are a niche market.
  • Stay Hydrated: Drink plenty of water before, during, and after consuming wine to combat dehydration, a major cause of hangover symptoms.
  • Eat While You Drink: Having a balanced meal slows down alcohol absorption, giving your body more time to process it.

Conclusion

While a glass of wine can be a delightful experience, the adage that some wines make you feel worse than others is grounded in science. The complex mix of natural compounds like congeners, histamines, and tannins, especially prevalent in red wines, can trigger headaches and other discomfort in sensitive individuals. Sulfites, while often blamed, are a less common culprit. By paying attention to the type of wine you drink and practicing moderation, you can mitigate the unpleasant side effects and continue to enjoy your favorite beverage responsibly. The key is to understand your body's unique reaction to these different components.

For more detailed information on specific wine compounds and their health effects, a valuable resource is the National Institutes of Health.

Frequently Asked Questions

Red wines often contain higher levels of congeners, histamines, and tannins compared to white wines. These compounds can be harder for the body to process, leading to more severe hangover symptoms like headaches and nausea.

For most people, it is unlikely. Sulfite sensitivity is rare and typically causes asthma-like symptoms or hives. Other compounds like histamines, tannins, and congeners, or simple dehydration, are more common culprits for wine headaches.

Organic wine can help reduce exposure to pesticides and added sulfites, which benefits overall health. However, organic certification does not guarantee low histamine or tannin levels, as these occur naturally during fermentation, so it may not prevent a reaction in sensitive individuals.

To prevent a wine headache, stay hydrated by drinking water between glasses of wine. You can also try choosing drier, lighter-colored wines and eating a full meal beforehand. Experimenting with different types may help you identify which compounds are triggers.

Alcohol intolerance is a genetic condition where the body lacks the proper enzymes to break down alcohol efficiently, leading to an accumulation of acetaldehyde. This can cause immediate and uncomfortable reactions like skin flushing, stuffy nose, and nausea.

Yes, sweeter wines often cause worse hangovers. The combination of alcohol and high sugar content exacerbates dehydration, which is a major contributor to hangover symptoms like headaches and fatigue.

The carbonation in sparkling wines speeds up the absorption of alcohol into the bloodstream. This means you can feel the effects of the alcohol more rapidly, potentially leading to a more intense experience and a worse hangover.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.