The Science of Human Growth Hormone (HGH)
Human Growth Hormone (HGH) is a naturally occurring hormone produced and released by the pituitary gland. Its primary role is to promote growth during childhood and adolescence. HGH stimulates the growth-promoting effect on cartilage and bone, especially at the growth plates, which are areas of cartilage located near the ends of long bones. During puberty, the growth plates fuse, and the bones can no longer lengthen. At this point, a person's final adult height is determined.
The Critical Difference: Prescription HGH vs. Dietary Supplements
It is crucial to understand the vast difference between medical-grade, injectable HGH and the so-called "growth hormone supplements" available on the market. Prescription HGH is a synthetic, biologically active hormone administered via injection and is strictly regulated by health authorities like the FDA. It is prescribed only for specific medical conditions, including HGH deficiency in children or chronic kidney disease. Its use is closely monitored by a doctor due to the potency and potential for side effects.
Conversely, most over-the-counter supplements do not contain actual HGH. They are often composed of amino acids, vitamins, and herbs that claim to boost the body's natural HGH production. The Federal Trade Commission (FTC) has found no reliable evidence to support these claims, and if taken orally, the stomach's digestive process would destroy the HGH before it could be absorbed anyway.
Can a Growth Hormone Supplement Increase Height?
For adults, the answer is a definitive no. As mentioned, once the growth plates have fused, the long bones can no longer grow in length. In adults, excess HGH does not lead to increased height but to a condition called acromegaly, which causes bones to thicken. This most notably affects the hands, feet, and face.
For children, the situation is different. If a child has a diagnosed growth hormone deficiency, a doctor may prescribe recombinant human growth hormone (rhGH) to help them reach a more normal adult height. The treatment is initiated before the growth plates close and can lead to a significant height increase compared to not receiving treatment. However, even in children with idiopathic short stature (ISS) but normal HGH levels, treatment with rhGH only leads to a modest increase in final adult height, and many remain short.
Risks and Dangers of Unapproved HGH Products
Using unapproved HGH supplements or illicit injectable HGH is illegal in many countries, including the United States, for non-medical use. The side effects and dangers are serious and can lead to permanent damage. The Endocrine Society does not recommend HGH injections for those without a diagnosed deficiency.
Potential side effects of misusing HGH include:
- Fluid retention, leading to swelling in the arms and legs.
- Joint and muscle pain.
- Carpal tunnel syndrome.
- High blood sugar levels, increasing the risk of diabetes.
- High cholesterol levels.
- Enlargement of hands, feet, and face (acromegaly).
- Weakening of the heart over the long term.
Comparison: Growth Hormone Supplements vs. Prescription HGH
| Feature | Growth Hormone Supplements (Over-the-Counter) | Prescription HGH (Injectable) |
|---|---|---|
| Form | Pills, powders, sprays | Daily or weekly injections |
| Content | Amino acids, herbs, vitamins; not actual HGH | Bioactive synthetic human growth hormone |
| Regulation | Largely unregulated; efficacy and safety are not guaranteed | Strictly regulated by health authorities (e.g., FDA) |
| Legality | Legal to purchase, but claims of height increase are misleading | Illegal for non-medical use in many countries |
| Effectiveness for Height | Not effective for increasing height at any age | Effective for increasing height in children with deficiencies before growth plates close |
| Potential Risks | Unknown risks, possible contaminants, or ineffective ingredients | Significant side effects, including acromegaly, if misused or unmonitored |
Conclusion: The Final Word on Growth Hormone and Height
The belief that a growth hormone supplement can increase height is a pervasive and dangerous myth. Supplements sold in stores have no evidence to support their claims and are not a substitute for medically prescribed HGH. Real height increase is only possible in children with certain medical conditions who receive carefully monitored, prescription HGH injections before their growth plates have fused. For adults, misusing HGH will not make you taller and carries serious, potentially irreversible health consequences. The best advice for anyone concerned about their height is to consult with a medical professional to understand the real physiological possibilities and risks involved. For more in-depth medical information on HGH and its applications, you can visit the Cleveland Clinic website.