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Does Natto Thicken Blood? The Truth About Nattokinase's Effect

4 min read

Invented in the 1980s by a Japanese researcher, the enzyme nattokinase found in the fermented soybean dish natto was discovered to have potent clot-dissolving abilities, a revelation that directly contradicts any notion that natto might thicken blood. This finding sparked a flurry of research into its positive effects on cardiovascular health.

Quick Summary

Natto contains the enzyme nattokinase, a potent fibrinolytic agent that actively dissolves blood clots, thins the blood, and improves circulation, contrary to the myth that it thickens blood.

Key Points

  • Blood-Thinning Properties: Natto contains the enzyme nattokinase, which acts as a natural blood thinner by dissolving fibrin, a protein that forms blood clots.

  • Contraindication to Thicken Blood: The core effect of natto on blood is to prevent clots, not cause them, which is a common but incorrect assumption.

  • Nattokinase vs. Vitamin K2: Whole natto contains both the blood-thinning nattokinase and vitamin K2, which supports clotting. Many supplements, however, remove vitamin K2 to focus solely on the fibrinolytic effect.

  • Consult a Physician: Anyone taking blood-thinning medication, such as warfarin, or facing surgery should consult a doctor before consuming natto or taking nattokinase supplements.

  • Cardiovascular Support: Beyond dissolving clots, nattokinase has been shown to help lower high blood pressure and reduce blood lipids, further contributing to heart health.

  • Rich in Probiotics: The fermentation process provides beneficial probiotics, which support gut health, a stronger immune system, and overall metabolic function.

In This Article

Understanding the Myth: Does Natto Thicken Blood?

The belief that natto could thicken blood is a common misconception, likely stemming from a confusion over its complex nutritional profile. In reality, the opposite is true. The sticky, fermented soybeans contain a powerful enzyme called nattokinase, which is highly prized for its fibrinolytic activity—meaning it breaks down fibrin, a protein that is the main component of blood clots. This process directly supports better blood flow and can help reduce blood viscosity, contributing to better cardiovascular health overall.

The Role of Nattokinase in Blood Health

Nattokinase is a serine protease produced by the bacterium Bacillus subtilis during the fermentation of soybeans. Its name is something of a misnomer, but its function is clear. It acts as a potent, systemic enzyme in the body with multiple mechanisms for promoting healthy blood circulation:

  • Direct Fibrin Dissolution: It directly degrades fibrin, the mesh-like protein that holds blood clots together. This helps in breaking down existing clots and preventing new ones from forming.
  • Enhancing the Body's Own Fibrinolytic System: Nattokinase helps activate plasminogen, which in turn produces plasmin, another enzyme that dissolves clots. It also degrades plasminogen activator inhibitor-1 (PAI-1), which further boosts the body's natural clot-busting activity.
  • Anti-Platelet Effects: Some research suggests that nattokinase can reduce platelet aggregation, preventing platelets from clumping together to form clots.

This multi-pronged approach to supporting healthy blood flow is why nattokinase is often referred to as a "natural blood thinner." Its discovery in the 1980s quickly led to its recognition as a therapeutic agent for cardiovascular health, with research focusing on its potential for preventing conditions like heart attacks and strokes.

Natto vs. Nattokinase Supplements

It is important to differentiate between consuming whole natto and taking a nattokinase supplement, as the two have different effects on blood coagulation. While the active ingredient in both is nattokinase, whole natto also contains other nutrients, most notably vitamin K2.

Comparing Nattokinase Sources

Feature Whole Natto (Fermented Soybeans) Nattokinase Supplements Considerations
Nattokinase Content Contains a good amount of nattokinase, though potency can vary. Often concentrated and standardized in Fibrinolytic Units (FU). Supplements offer a more consistent, measured dose of the active enzyme.
Vitamin K2 Rich in vitamin K2 (menaquinone-7), which promotes blood clotting and bone health. Many high-quality supplements are designed to be vitamin K2-free to avoid interfering with anticoagulant medications. Vitamin K2 and nattokinase have opposing effects on clotting. Whole natto provides both.
Blood-Thinning Potency The presence of vitamin K2 can slightly moderate the blood-thinning effect of nattokinase. Without vitamin K2, the blood-thinning effect is more pronounced and predictable. Choice depends on individual health goals and any existing medical conditions or prescriptions.
Other Nutrients A probiotic superfood, also rich in fiber, protein, and other vitamins and minerals. Typically contains only nattokinase (and sometimes other heart-healthy ingredients like OPC or ginger). Whole natto offers a broader nutritional benefit, while supplements are targeted.

Health Benefits Beyond Blood Thinning

The positive effects of natto extend beyond just blood viscosity. Its rich composition contributes to several aspects of overall health:

  • Cardiovascular Health: Regular consumption is associated with a lower risk of death from cardiovascular diseases. It may also help lower high blood pressure by regulating blood flow and reducing arterial stiffness.
  • Improved Gut Health: As a fermented food, natto provides beneficial probiotic bacteria that support a healthy gut microbiome, which is linked to a stronger immune system and better digestion.
  • Bone Health: The high vitamin K2 content in whole natto is crucial for directing calcium to the bones and teeth, preventing its buildup in arteries where it can cause harm.
  • Anti-inflammatory Effects: Nattokinase, along with other compounds in natto, may help combat chronic inflammation, a factor in many chronic diseases.

Important Precautions

While natto and nattokinase are widely considered safe for most healthy people, some individuals should exercise caution or avoid them entirely:

  1. If you are on blood-thinning medication: The most significant caution is for individuals taking anticoagulant drugs like warfarin. Combining nattokinase with these medications can amplify their effects and lead to excessive bleeding or bruising. A doctor's supervision is essential.
  2. Before surgery: Nattokinase should be discontinued at least two weeks before any scheduled surgical procedure, including dental surgery, to minimize the risk of excessive bleeding.
  3. Pregnancy and breastfeeding: There is a lack of reliable data regarding the safety of nattokinase during pregnancy and breastfeeding, so it is recommended to avoid supplementation during these times.
  4. Blood disorders: People with bleeding disorders like hemophilia should avoid nattokinase as it could worsen their condition.

Always consult a healthcare provider before adding nattokinase supplements to your regimen, especially if you have an existing health condition or take other medications.

Conclusion: Does Natto Thicken Blood?

To definitively answer the question, no, natto does not thicken blood. The available scientific evidence overwhelmingly points to the contrary, highlighting natto's potential to thin the blood and improve cardiovascular health through the enzyme nattokinase. By dissolving fibrin and supporting the body's natural fibrinolytic processes, nattokinase can help prevent and even dissolve existing blood clots. However, due to its powerful effects, particularly when in supplement form, it is crucial to understand the distinction between whole natto and nattokinase supplements and to seek medical advice if you are on any anticoagulant medication or have a pre-existing bleeding disorder. Embracing natto can be a powerful and natural way to support your heart and blood circulation, but it should be approached with knowledge and proper medical guidance.

For more detailed scientific information on nattokinase, refer to resources such as Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Diseases.

Frequently Asked Questions

Yes, regular consumption of natto introduces nattokinase into your body, which acts as a natural blood thinner by helping to break down blood clots and improve overall blood circulation.

Nattokinase has natural blood-thinning properties, but it works differently and is not a replacement for prescription medications like warfarin. People on such medications should not take nattokinase without strict medical supervision.

Nattokinase can lower blood pressure, and combining it with blood pressure medication may cause your blood pressure to drop too low. You should monitor your blood pressure closely and consult with your healthcare provider before combining them.

Yes, research indicates that nattokinase possesses potent fibrinolytic properties, meaning it can help dissolve existing blood clots as well as prevent new ones from forming. However, it should only be used as a treatment under a doctor's guidance.

Vitamin K2, which is naturally present in whole natto, promotes blood clotting. It is often removed from supplements to ensure a more potent and predictable blood-thinning effect, which is critical for people concerned about excessive clotting.

Nattokinase is generally considered safe with few side effects. The main risks are related to its blood-thinning effect, which can increase the risk of bleeding or bruising, especially when combined with other anticoagulants.

Yes, it is highly recommended to stop taking nattokinase at least two weeks before any scheduled surgery, including dental surgery, to minimize the risk of excessive bleeding during and after the procedure.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.