Dominos Pizza Nutrition Guide: How many calories are in one slice of Domino's New York pizza?

October 27, 2025 •

4 min read

According to nutrition data, a single slice of New York style pizza can contain over 500 calories, but the precise calorie count for a Domino's slice depends on its size and toppings. This guide answers the question of how many calories are in one slice of Domino's New York pizza? by providing a comprehensive overview of nutritional information for various versions of this popular menu item.

Quick Summary

The calories in a single slice of Domino's New York style pizza vary based on size and toppings, from approximately 325 to 580 or more. Factors like pepperoni and sausage significantly increase the calorie count, highlighting the importance of checking specific nutritional information for each pizza type.

Key Points

Toppings increase calories: Toppings like pepperoni and sausage significantly increase the calorie count of Domino's New York style pizza slices.
Size matters: Because New York style pizzas are cut into larger, foldable slices (typically 6 per pie), a single slice contains more calories than a slice from a standard 8-piece pizza.
A large cheese slice has ~390 calories: For a large Domino's New York Style Cheese Pizza, one slice is approximately 390 calories.
An extra large pepperoni and sausage slice has ~580 calories: The highest calorie New York style option detailed is the extra large Pepperoni & Sausage, with around 580 calories per slice.
Healthier options exist: To manage calories, choose fewer toppings, opt for leaner protein like chicken, and consider pairing your pizza with a salad.
Crust type influences calories: A thinner crust, like Domino's Thin Crust, inherently has fewer calories and carbohydrates than the New York style or hand-tossed versions.

The introduction of Domino's New York Style pizza has offered customers a foldable, thin-crust alternative to their classic hand-tossed and pan options. However, the nutritional profile of this style can vary significantly depending on toppings and slice size. Understanding these variations is key for anyone monitoring their caloric intake. The slices for Domino's New York Style pizzas are larger and are cut into six pieces, unlike the eight slices of a hand-tossed pizza, which naturally affects the per-slice calorie count.

Calorie Breakdown of Domino's New York Style Pizza

The calorie content for a single slice of Domino's New York style pizza can differ based on the specific pizza ordered. Below is a breakdown of calorie estimates based on the topping and size, referencing available nutritional data.

Large Cheese: A large Domino's New York Style Cheese Pizza is typically cut into 6 slices. Each slice contains approximately 390 calories.
Large Pepperoni: A large Domino's Pepperoni New York Style Pizza, also cut into 6 slices, contains about 325 calories per slice.
Extra Large Pepperoni: For a larger portion, an extra large Pepperoni New York Style pizza provides about 460 calories per slice, with the pizza also cut into 6 pieces.
Extra Large Pepperoni & Sausage: The extra large Pepperoni & Sausage pizza is a higher-calorie option, with a single slice containing approximately 580 calories.
Extra Large Mushrooms, Black Olives & Onions: For a vegetable-focused pizza, the extra large Mushrooms, Black Olives & Onions option has a lower calorie count of 440 per slice.

Factors Influencing Pizza Calories

The toppings are a major factor in determining the final calorie count of your pizza. Ingredients like sausage and pepperoni are dense in fats and proteins, which increase the overall caloric load. In contrast, a cheese-only or vegetable-heavy pizza will have a lower calorie density per slice, especially when opting for a thinner crust. Understanding these components can help you make more informed choices.

Size and Portion Control

Size also plays a significant role. A single, large New York style slice is physically bigger than a slice from a standard hand-tossed or thin-crust pizza. This larger portion size means that even with similar ingredients, the calorie and nutrient intake per slice will be higher. Mindful eating and portion control are crucial when enjoying larger slices of pizza.

Nutritional Comparison: Domino's New York Style vs. Other Pizzas

To put the New York style slice into perspective, here is a comparison table showing the approximate nutritional information for different Domino's pizza types per slice. These values can help you compare and select a pizza that better fits your dietary needs. Note that serving sizes can vary, so always confirm with the official Domino's nutrition information.


Pizza Type	Style	Approximate Calories (per slice)	Protein (g)	Fat (g)	Sodium (mg)
New York Style Cheese (Large)	New York	390	17	15	780
New York Style Pepperoni (Extra Large)	New York	460	17	20	860
Hand Tossed Cheese (Large)	Classic	270-300	12.2	10	640
Thin Crust Cheese (Medium)	Thin	133	~6	~4	N/A
Pepperoni (Average Slice)	Standard	310	13	12	N/A

How to Enjoy Pizza on a Diet

For those watching their calorie intake, indulging in pizza doesn't have to be off-limits. By making smart choices, you can still enjoy your favorite meal while adhering to your dietary goals.

Choose a thinner crust: Opting for a thin crust or even a cauliflower crust can significantly reduce the calorie and carbohydrate load.
Load up on veggies: Add extra vegetables like bell peppers, mushrooms, and onions to boost the fiber and nutrient content.
Choose leaner proteins: Swap processed meats like pepperoni and sausage for leaner options like grilled chicken.
Blot away excess oil: Dabbing the surface of your pizza with a napkin can remove a noticeable amount of excess oil, and therefore fat and calories.
Eat mindfully: Pay attention to your hunger and fullness cues to prevent overeating. Savoring each bite can lead to greater satisfaction with fewer slices.
Pair with a salad: Complement your slice with a side salad to add more fiber and nutrients to your meal, helping you feel fuller faster.

Conclusion

While a slice of Domino's New York style pizza can be high in calories, understanding the specific nutritional information is the first step toward enjoying it responsibly. By being mindful of your toppings, portion size, and overall meal composition, it is entirely possible to incorporate pizza into a balanced diet. Whether you choose a large pepperoni slice at 325 calories or an extra large pepperoni and sausage at 580, making informed decisions ensures you can still enjoy a delicious meal without completely derailing your nutrition goals.

Domino's Pizza Nutrition Information offers a comprehensive ingredient and allergen guide for their various menu items.

Frequently Asked Questions

A large Domino's New York style cheese pizza slice contains approximately 390 calories, though it is important to confirm with the specific location's nutrition facts.

A slice of Domino's New York style pizza often has more calories than a standard or regular slice because it is cut larger. For instance, a large New York style pepperoni slice has 325 calories, while a regular hand-tossed pepperoni slice is typically around 270-300 calories.

Based on the available search data, the extra large Pepperoni and Sausage New York style pizza is among the highest, with approximately 580 calories per slice.

Yes, blotting the oil from your pizza can help reduce the calorie content, as you are removing some of the fat and saturated fat before consuming it.

For a healthier option, choose a thin crust, load up on vegetable toppings, select leaner protein options like chicken, and pair your pizza with a side salad to increase fiber intake.

Domino's New York style pizza is specifically designed to be cut into six large, foldable slices.

Yes, it is possible to eat Domino's pizza while on a diet by practicing mindful eating, controlling portion sizes, and choosing lower-calorie options like a thin crust with vegetable toppings.