The Initial Onset: The First 1-3 Months
Scurvy symptoms typically appear after 8 to 12 weeks of insufficient vitamin C intake, as the body's stores (up to 1,500 mg) become depleted. Early symptoms are often non-specific and may include:
- Malaise and Fatigue: A common early indicator.
- Irritability and Depression: Mood changes may occur.
- Muscle and Joint Pain: Aches are frequent.
- Loss of Appetite and Weight Loss: A decrease in appetite can lead to weight loss.
The Advanced Stages: Months 3 and Beyond
As vitamin C deficiency worsens, classic symptoms emerge due to impaired collagen synthesis. These include:
- Gingival Disease: Swollen, bleeding gums are a hallmark.
- Skin Manifestations: Easy bruising and perifollicular hemorrhages appear.
- Corkscrew Hairs: Body hair may become coiled.
- Poor Wound Healing: Wounds heal slowly or reopen.
- Anemia: Vitamin C deficiency can affect iron absorption.
- Musculoskeletal Bleeding: Internal bleeding in muscles and joints causes pain.
The Final and Potentially Fatal Stage
Untreated scurvy can lead to life-threatening complications:
- Generalized Edema: Widespread swelling.
- Jaundice: Yellowing of skin and eyes.
- Neuropathy: Nerve damage.
- Convulsions: Seizures can occur.
- Death: The risk of death is high from severe infection or internal bleeding.
Scurvy Progression and Risk Factors
Scurvy progression depends on the duration and severity of vitamin C deficiency. Risk factors include:
- Restricted Diets: Lack of fruits and vegetables is a primary cause.
- Alcoholism and Substance Abuse: Affects diet and nutrient absorption.
- Certain Medical Conditions: Malabsorption disorders increase risk.
- Smoking: Reduces vitamin C absorption.
A Comparison of Mild Versus Severe Scurvy
The table below contrasts the symptoms of mild and severe scurvy:
| Symptom Category | Mild, Early Scurvy | Severe, Advanced Scurvy | 
|---|---|---|
| General | Fatigue, irritability | Extreme weakness, confusion, fever | 
| Skin | Easy bruising | Pinpoint red spots, widespread bruising | 
| Oral Health | Mild gum inflammation | Swollen, bleeding gums, loose teeth | 
| Musculoskeletal | Vague aches | Severe joint pain, swelling | 
| Internal Bleeding | None or minimal | Gastrointestinal, cerebral hemorrhage | 
The Reversal of Scurvy
Scurvy is treatable with vitamin C. Improvement is rapid:
- Within 24-48 hours: Fatigue and malaise improve.
- Within 1-2 weeks: Gum bleeding and bruising resolve.
- Within 3-4 weeks: Hair abnormalities normalize.
- Within 3 months: Full recovery is expected.
Conclusion
Scurvy progression depends on vitamin C deficiency severity, with symptoms appearing within months. Untreated, it can lead to severe complications. Recognizing early signs is vital for prompt treatment. Scurvy is preventable with a diet rich in vitamin C and quickly reversible with supplementation. Maintaining adequate nutritional intake, especially for high-risk individuals, is key to preventing this disease. For more information on vitamin C sources, visit the Office of Dietary Supplements at the National Institutes of Health.