How much protein is in 1 slice of pepperoni pizza from Little Caesars?

October 24, 2025 •

3 min read

According to the University of Rochester Medical Center, a single slice of Little Caesars 14" Original Round Pepperoni Pizza contains approximately 12 grams of protein. While the exact amount can vary based on crust type, this figure provides a good baseline for understanding how much protein is in 1 slice of pepperoni pizza from Little Caesars.

Quick Summary

The protein content in a single slice of Little Caesars pepperoni pizza varies by crust type. Regular round pizza has about 12g of protein, while the deep-dish version offers slightly more. The ExtraMostBestest pepperoni pizza can provide up to 15g per slice. This difference is due to varying amounts of cheese and meat used for each product.

Key Points

Original Round Pizza: A single slice of the standard 14" pepperoni pizza from Little Caesars offers approximately 12 grams of protein.
Deep Dish Pizza: The thicker Deep Dish pepperoni pizza contains a higher protein count, providing around 16 grams per slice due to more ingredients.
ExtraMostBestest Pizza: With more cheese and toppings, a slice of this pizza can yield about 15 grams of protein, a slight increase over the regular round option.
Serving Size Varies: The protein per slice is based on a standard 1/8th cut, and changes if the pizza is divided differently.
Ingredient Impact: The primary sources of protein in the pizza are the cheese and pepperoni topping, with the crust contributing a smaller amount.
Context is Key: While pizza provides protein, it should be consumed in moderation as part of a balanced diet due to high levels of sodium and fat.

Understanding the Protein in Little Caesars Pizza

For many people tracking their nutrition, understanding the macronutrient breakdown of their favorite fast foods is key. A popular question often revolves around the protein content of pizza, specifically, "how much protein is in 1 slice of pepperoni pizza from Little Caesars?" The answer is not one-size-fits-all, as it depends on which pepperoni pizza you choose.

The Original Round Pepperoni Pizza

The most common Little Caesars option, the classic Hot-N-Ready Original Round Pepperoni, offers a respectable amount of protein per slice. The University of Rochester Medical Center provides detailed nutritional data confirming that one slice (1/8th of a 14" pizza) contains about 12 grams of protein. This protein comes primarily from the cheese and the pepperoni topping.

Key nutritional facts for a slice of the Original Round Pepperoni pizza:

Protein: ~12g
Calories: ~246 kcal
Total Fat: ~9.5g
Carbohydrates: ~28g
Sodium: ~466mg

This makes it a surprisingly solid source of protein, especially when considering the convenience and cost.

Deep Dish Pepperoni Pizza

For those who prefer a thicker, more substantial slice, Little Caesars' Deep Dish pizza is a different story. The square slices are generally larger and denser, which means they pack a bigger nutritional punch. CalorieKing.com data indicates that a slice of the Deep Dish Pepperoni pizza contains about 16 grams of protein, a noticeable increase from the standard round pizza.

Additional nutrition for a slice of Deep Dish Pepperoni:

Protein: ~16g
Calories: ~360 kcal
Total Fat: ~16g
Carbohydrates: ~38g
Sodium: ~640mg

The higher protein count is a result of more cheese and a thicker crust, making it a more filling option.

ExtraMostBestest Pepperoni Pizza

Little Caesars also offers the ExtraMostBestest pizza, known for its larger quantity of toppings and cheese. While official figures can vary, nutrition trackers suggest this version packs even more protein. A slice of the Large ExtraMostBestest Pepperoni pizza can provide around 15 grams of protein. The increased cheese is the main driver behind the higher protein count, but it also comes with more calories and fat.

Factors Influencing Protein Content

Several factors can cause slight variations in the reported protein content per slice, including:

Serving Size: The number of slices a pizza is cut into directly impacts the per-slice nutritional data. A standard 14" pizza is typically cut into 8 slices. If a pizza is cut into smaller or larger pieces, the protein per slice will change.
Ingredient Distribution: The amount of cheese and pepperoni can differ slightly from pizza to pizza, leading to minor variations.
Crust Thickness: As seen with the Deep Dish pizza, a thicker crust can change the overall composition and nutritional profile of each slice.

Comparison of Little Caesars Pepperoni Pizza Slices


Pizza Type	Protein per Slice (approx.)	Calories per Slice (approx.)	Notes
Original Round	12g	246	Standard, widely available option
Deep Dish	16g	360	Thicker crust with more cheese and meat
ExtraMostBestest	15g	Not consistently listed	Extra cheese and pepperoni added

Note: Calorie and macronutrient data can be subject to small changes by the company. Always refer to the official Little Caesars nutrition information for the most accurate and current details.

Conclusion: Making an Informed Pizza Choice

Ultimately, a single slice of Little Caesars pepperoni pizza provides a decent amount of protein, ranging from 12 to 16 grams depending on the crust style. While this can contribute to your daily protein intake, it's important to view it within the context of a balanced diet. Pizza is often high in sodium and saturated fat, so moderation is key. If you're looking for a higher-protein option, the Deep Dish or ExtraMostBestest versions offer a more substantial protein boost per slice due to their increased cheese and meat toppings. Knowing these differences can help you make a more informed decision next time you reach for that Hot-N-Ready box.

For more detailed information on nutrition, consult a resource like Verywell Fit, which provides thorough breakdowns of fast food menus.

Frequently Asked Questions

Yes, a slice of the Little Caesars Deep Dish pepperoni pizza typically has more protein than the standard round version. The Deep Dish has approximately 16 grams of protein per slice, compared to about 12 grams in the Original Round.

The main sources of protein are the cheese and the pepperoni topping. The amount of these ingredients directly correlates with the overall protein content per slice.

A single slice offers a moderate amount of protein. While it can contribute to your daily intake, it's not a primary source and should be balanced with other nutrient-dense foods, given its higher fat and sodium content.

A slice of the Large ExtraMostBestest pepperoni pizza from Little Caesars is reported to contain around 15 grams of protein, more than the standard Hot-N-Ready due to the extra cheese and toppings.

The crust thickness and toppings significantly impact the protein. Thicker crusts like the Deep Dish often have more cheese and sauce per slice, leading to more protein compared to thinner crust options.

Yes, the size of the slice is crucial. All nutritional information is based on a standard serving size (typically 1/8th of a large pizza). If the pizza is cut differently, the per-slice nutrition will change proportionally.

For the most accurate and up-to-date nutritional data, you should check the official Little Caesars website or their nutrition guide. Resources like the University of Rochester Medical Center and CalorieKing also provide reliable, cited data.