Skip to content

Is magnesium Bisglycinate the same as regular magnesium?

4 min read

Despite being an essential mineral involved in hundreds of bodily functions, dietary surveys show nearly half of all Americans consume less than the recommended daily intake of magnesium. This widespread deficiency has led many to consider supplements, but is magnesium bisglycinate the same as regular magnesium? The crucial differences lie in chemical structure and bioavailability.

Quick Summary

Magnesium bisglycinate is not the same as common forms like magnesium oxide due to chelation. Its structure provides higher bioavailability and is gentler on the digestive system, making it more effective for raising magnesium levels and promoting relaxation.

Key Points

  • Chemical Structure: Bisglycinate is a chelated form, with magnesium bonded to two glycine molecules, whereas 'regular' magnesium often refers to inorganic salts like magnesium oxide.

  • Bioavailability: Magnesium bisglycinate is significantly more bioavailable than magnesium oxide, meaning a much higher percentage is absorbed by the body.

  • Digestive Comfort: Bisglycinate is gentle on the stomach and less likely to cause diarrhea or other gastrointestinal issues common with poorly absorbed forms.

  • Calming Effects: The amino acid glycine in bisglycinate provides additional calming benefits, aiding in sleep and anxiety reduction.

  • Intended Purpose: While bisglycinate is effective for raising systemic magnesium levels, forms like oxide are often used primarily for their laxative or antacid effects.

  • Value: Although often more expensive, bisglycinate's high absorption provides better value per absorbed unit of magnesium compared to cheaper, poorly absorbed forms.

In This Article

What is 'Regular' Magnesium?

When people refer to 'regular' magnesium, they are often thinking of the most common and inexpensive forms found in supplements and over-the-counter products, such as magnesium oxide. Found in antacids and laxatives, magnesium oxide is a magnesium salt with poor solubility and very low bioavailability, meaning a large portion is not absorbed by the body. Because it remains unabsorbed in the gut, it attracts water, which is what produces its significant laxative effect. While it contains a high percentage of elemental magnesium by weight, the body simply cannot use most of it, making it an ineffective choice for correcting a systemic magnesium deficiency.

Understanding Magnesium Bisglycinate

Magnesium bisglycinate is a specific, chelated form of magnesium. Chelation is a process where the mineral is bonded to an amino acid to improve its absorption and stability. In this case, magnesium is bound to two molecules of the amino acid glycine.

This chelated structure is the core difference. It acts like a protected vehicle, allowing the magnesium to pass through the intestinal wall more easily and without interference from other compounds. The added glycine also provides calming benefits, as it is a known neurotransmitter that promotes relaxation.

Bioavailability and Absorption

The most significant advantage of magnesium bisglycinate over inorganic forms like magnesium oxide is its superior bioavailability. A high bioavailability means a greater proportion of the magnesium is absorbed and utilized by the body, rather than being excreted or causing digestive issues.

Studies suggest that magnesium bisglycinate has a much higher absorption rate, with one source citing up to 80-90% bioavailability compared to magnesium oxide's mere 4-15%. This superior absorption is why bisglycinate is often the preferred choice for people looking to effectively increase their magnesium levels and address a deficiency, rather than simply needing a laxative.

Key Benefits and Uses

The benefits associated with magnesium bisglycinate are linked to both the highly absorbable magnesium and the calming amino acid glycine. Key uses include:

  • Promoting Relaxation: The glycine component has a calming effect on the nervous system, helping to reduce stress and anxiety.
  • Improving Sleep Quality: By promoting relaxation and regulating neurotransmitters like GABA, bisglycinate can help individuals fall asleep faster and achieve more restorative sleep.
  • Relieving Muscle Cramps: Magnesium is a natural muscle relaxant, and the highly absorbable nature of bisglycinate can help alleviate muscle tension and nighttime leg cramps.
  • Gentle on Digestion: Unlike many other magnesium supplements, bisglycinate is less likely to cause digestive side effects like diarrhea, making it suitable for those with sensitive stomachs.
  • Enhancing Overall Magnesium Levels: Due to its high bioavailability, it is an effective way to replenish magnesium stores throughout the body for overall health and wellness.

Comparison of Magnesium Bisglycinate vs. Common Forms

To highlight the key differences, here is a comparison table of magnesium bisglycinate and common inorganic forms, like magnesium oxide:

Feature Magnesium Bisglycinate Common Forms (e.g., Oxide)
Chemical Structure Chelated (Magnesium bound to two glycine molecules) Inorganic salt
Bioavailability Very High (up to 90% in some studies) Very Low (4-15% in some studies)
Digestive Impact Gentle on the stomach; low laxative effect Can cause significant laxative effects, cramping, and diarrhea
Primary Uses Replenishing magnesium levels, anxiety, sleep, muscle relaxation Constipation relief, antacid
Cost Generally more expensive due to advanced chelation Inexpensive

How to Choose the Right Supplement for Your Needs

Choosing the right form of magnesium is a personalized journey that depends on your specific health goals.

  • For Systemic Deficiency: If your goal is to correct a true magnesium deficiency or support functions like sleep, mood, and muscle relaxation, magnesium bisglycinate is the superior choice. Its high absorption ensures that the mineral reaches your cells where it is most needed.
  • For Digestive Issues: If your primary concern is occasional constipation or acid indigestion, a less absorbable form like magnesium oxide or magnesium citrate may be suitable. However, be aware of the potential for digestive side effects.
  • For Sensitive Stomachs: For those who experience gastrointestinal distress with other supplements, bisglycinate's gentle nature makes it an ideal option for consistent, long-term use.

It is important to remember that not all supplements are created equal. When selecting a magnesium bisglycinate product, look for brands that prioritize quality and use reputable ingredients to ensure you are getting a pure and potent product. For more information on the functions of magnesium, visit the National Institutes of Health fact sheet on Magnesium.

Conclusion

While the names 'magnesium bisglycinate' and 'regular magnesium' might sound similar, they are fundamentally different in both their chemical structure and their effect on the body. The key lies in chelation. Magnesium bisglycinate is a highly bioavailable, gentle, and effective form for raising magnesium levels and offering calming benefits, making it an excellent choice for overall wellness. In contrast, 'regular' magnesium, often in the form of magnesium oxide, is poorly absorbed and primarily acts as a laxative. Understanding these distinctions is essential for making an informed choice that aligns with your health objectives.


Note: This article is for informational purposes only and is not medical advice. Consult a healthcare professional before starting any new supplement.

Frequently Asked Questions

Yes, they are often used interchangeably. 'Bisglycinate' is the more chemically accurate term, referring to the chelation with two glycine molecules, but 'glycinate' is more commonly used on product labels.

Magnesium oxide has very low bioavailability, with an absorption rate as low as 4%. This means most of the magnesium is not absorbed and utilized by the body, making it a poor choice for correcting a deficiency.

Its primary benefits include promoting relaxation, improving sleep quality, reducing muscle cramps and tension, and being very gentle on the digestive system due to its high absorbability.

Yes, due to its high tolerability and gentle nature, it is often well-received even when taken without food. It is less likely to cause the stomach upset or diarrhea associated with other forms.

Magnesium citrate or magnesium oxide are commonly used as laxatives due to their osmotic effects, which draw water into the intestines. Magnesium bisglycinate is not the ideal choice for this purpose.

The effects on relaxation and sleep can often be felt relatively quickly, sometimes within hours or days. For more profound and lasting benefits, such as mood support, consistent use over several weeks may be necessary.

Yes, magnesium bisglycinate is generally considered safe and well-tolerated for daily, long-term supplementation. Its gentle effect on the stomach makes it a reliable choice for consistent use without causing digestive issues.

References

  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.