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Is there a difference between magnesium glycinate and magnesium bisglycinate?

4 min read

According to the National Institutes of Health, a significant portion of the population does not meet the recommended daily intake of magnesium through diet alone. As people turn to supplements, a common point of confusion arises: is there a difference between magnesium glycinate and magnesium bisglycinate? While the names suggest a distinction, the reality is more nuanced, boiling down to scientific terminology versus common market names.

Quick Summary

This article explains the relationship between magnesium glycinate and magnesium bisglycinate, which are essentially the same highly bioavailable chelated compound. The primary difference is terminology: 'bisglycinate' is the precise chemical name, while 'glycinate' is the common label. Highlighting the importance of chelation for absorption, it provides guidance on recognizing quality supplements for better digestion, sleep, and overall health.

Key Points

  • Terminological Difference: 'Magnesium bisglycinate' is the more precise chemical term for a fully chelated magnesium compound, while 'magnesium glycinate' is the common, simplified consumer name for the same substance.

  • Superior Bioavailability: The chelation process, especially in the fully reacted 'bisglycinate' form, results in higher absorption rates and improved stability within the digestive system compared to less effective magnesium forms like oxide.

  • Gentle on Digestion: Both forms, when properly chelated, are very gentle on the stomach and are significantly less likely to cause the laxative effects associated with other magnesium types, making them ideal for sensitive individuals.

  • Dual Benefits: Because magnesium is chelated to the amino acid glycine, these supplements offer a double benefit: the muscle-relaxing effects of magnesium and the calming, sleep-promoting effects of glycine.

  • Varying Quality: The term 'magnesium glycinate' can sometimes be used for lower-quality products that are not fully chelated. To ensure purity and effectiveness, look for labels that specify 'magnesium bisglycinate chelate' or feature a trusted patent like TRAACS®.

  • Better Absorption, Better Value: While potentially more expensive upfront, the superior absorption of fully chelated bisglycinate means you get more benefit per dose, making it a more cost-effective choice in the long run.

In This Article

Understanding Magnesium Chelation

To understand the distinction, one must first grasp the concept of chelation. In the context of supplements, chelation is a process where a mineral ion, like magnesium, is bonded to an organic molecule, often an amino acid. This binding creates a stable compound that is protected from interacting with other substances in the digestive tract, which greatly enhances its absorption.

The Role of Glycine

Both magnesium glycinate and magnesium bisglycinate are chelated to the amino acid glycine. Glycine is known for its calming properties, and when combined with magnesium, it offers a dual benefit for promoting relaxation and improving sleep quality.

The Naming Convention Explained

At its core, the difference between the names is a matter of technical accuracy versus common usage. 'Bis' is a chemical prefix meaning 'two'. Therefore, magnesium bisglycinate literally translates to 'magnesium with two glycine molecules'. This accurate chemical description reflects the structure of a fully chelated magnesium molecule bonded to two glycine molecules.

For consumer products, the term 'magnesium glycinate' is often used interchangeably and simplifies the name for the general public. In the vast majority of high-quality supplement brands, when they label a product as 'magnesium glycinate,' they are in fact selling the fully chelated magnesium bisglycinate.

Potential for Deception

This naming convention can be misleading in lower-quality supplements. Some companies may use the broader term 'magnesium glycinate' to describe a product that is not fully chelated. This could mean the product contains a mix of magnesium and glycine, or is a partially reacted formula, which can impact absorption and effectiveness.

  • Fully Chelated (Bisglycinate): The magnesium ion is securely bonded with two glycine molecules. This creates a stable compound that is highly bioavailable and gentle on the stomach.
  • Partially Chelated or Blended (Glycinate): The bonding is not complete or is inconsistent. The product might contain cheaper, less absorbable forms of magnesium (like oxide) mixed with glycine to appear more desirable.

Comparison Table: Glycinate vs. Bisglycinate

Feature Magnesium Glycinate (Common Label) Magnesium Bisglycinate (Accurate Label)
Chemical Structure Can be a broad term; potential for variability in chelation. Specifically refers to a magnesium ion bonded to two glycine molecules.
Purity & Quality Varies widely. Could be fully chelated or a lower-quality mix. Depends on the brand. Higher assurance of being a fully chelated, highly absorbable form.
Bioavailability High, but can be inconsistent if not fully chelated. Generally considered superior due to the stable, fully chelated structure.
Digestive Tolerance Gentle on the stomach; less likely to cause a laxative effect. Exceptionally gentle and well-tolerated, ideal for sensitive stomachs.
Effectiveness Highly effective for promoting sleep and relaxation. May be slightly more effective for sleep and muscle recovery due to enhanced absorption.

The Traacs® Standard

For consumers seeking the highest quality and assurance, some brands feature a patented form of chelated magnesium known as TRAACS® (The Real Amino Acid Chelate System) from Albion Laboratories. This is a guarantee that the product is a fully reacted, true bisglycinate chelate, backed by research confirming its superior absorption.

How to Choose the Right Supplement

When standing in the supplement aisle, the key is to look beyond the general 'glycinate' label. Here's a quick guide:

  1. Read the label carefully: Look for phrases like 'bisglycinate chelate' or 'fully chelated' to confirm the product's quality.
  2. Look for trusted brands: Reputable brands are transparent about their formulations. A brand that specifies 'magnesium bisglycinate' or mentions third-party certifications is a good sign.
  3. Consider the manufacturer: Some brands partner with companies like Albion Minerals to use their patented TRAACS® form, indicating a premium, highly absorbable product.
  4. Prioritize your needs: While both are excellent for sleep and relaxation, those with particularly sensitive stomachs may find the superior stability of a guaranteed bisglycinate chelate beneficial.

Conclusion

In summary, while the chemical names differ, high-quality magnesium glycinate and magnesium bisglycinate are fundamentally the same highly absorbable, chelated compound. The term 'bisglycinate' is the precise chemical name for a magnesium ion bonded to two glycine molecules, whereas 'glycinate' is the more common and simplified consumer term. The key takeaway is that the supplement's quality and the integrity of its chelation process matter far more than the name on the front of the label. By looking for 'fully chelated' forms or brands that utilize patented ingredients like TRAACS®, consumers can ensure they are receiving the most bioavailable and gentle form of magnesium, delivering the intended benefits for sleep, relaxation, and overall wellness.

Actionable Takeaways for Magnesium Supplementation

To maximize the benefits of chelated magnesium, consider a supplement containing a fully reacted form like Albion's TRAACS® magnesium bisglycinate. This guarantees a higher level of absorption and fewer gastrointestinal side effects compared to lower-quality blends. Take your supplement in the evening to leverage the calming effects of glycine for improved sleep quality.

Shop high-quality magnesium bisglycinate supplements here.

Frequently Asked Questions

In most cases, yes, they are the same highly absorbable chelated compound. Magnesium bisglycinate is the scientifically accurate chemical name, while magnesium glycinate is the common, consumer-friendly term used on supplement labels.

Both magnesium glycinate and bisglycinate are excellent for promoting sleep and relaxation. The calming effects are attributed to the amino acid glycine to which the magnesium is chelated.

Magnesium bisglycinate is known for its high digestive tolerance and is one of the gentlest forms of magnesium. It is far less likely to cause stomach upset or a laxative effect compared to other types like magnesium oxide or citrate.

Look for labels that specify 'fully chelated' or 'bisglycinate chelate.' Some reputable brands use patented forms like TRAACS®, which guarantees a high-absorption, fully reacted product.

The term 'glycinate' is a simpler and more widely recognized market name for consumers. While most quality brands use it to refer to the same compound, it can sometimes be used by lower-quality companies to label products that are not fully chelated.

Yes, chelated magnesium is generally considered superior because it is bound to an amino acid, which protects it during digestion and leads to significantly higher bioavailability and better absorption by the body.

For relaxation and sleep support, many people find it most effective to take their supplement 30 to 60 minutes before bedtime. However, it can be taken at any time of day, preferably with a meal for optimal absorption.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.