Skip to content

L-Citrulline vs. Citrulline Malate: What's the Best Form of Citrulline?

4 min read

Studies show that supplementing with citrulline can significantly enhance athletic performance by boosting nitric oxide production and improving blood flow to working muscles. The question of what's the best form of citrulline—L-citrulline or citrulline malate—often depends on your specific fitness goals.

Quick Summary

A comparison between L-citrulline and citrulline malate for athletic performance, explaining differences in composition, benefits for pumps and endurance, and how to choose based on training needs.

Key Points

  • L-Citrulline: A purer form best for maximizing muscle pumps due to its high concentration of nitric oxide-boosting compounds per gram.

  • Citrulline Malate: Combines citrulline with malic acid, which helps boost energy production and is ideal for enhancing endurance and fighting fatigue.

  • Consider Amount: Achieving desired effects may require different amounts of each form.

  • Consider Your Goal: Choose L-citrulline for pure pump focus or citrulline malate for broader performance benefits including endurance.

  • Side Effects are Minimal: Both forms are generally safe and well-tolerated, with mild gastrointestinal discomfort being a rare potential side effect.

In This Article

Understanding Citrulline's Role

Citrulline is a non-essential amino acid that plays a vital role in the body, primarily by boosting levels of the amino acid L-arginine and subsequently nitric oxide (NO). This increase in NO causes vasodilation, which is the widening of blood vessels, leading to enhanced blood flow, oxygen, and nutrient delivery to muscles during exercise. Additionally, citrulline helps in the removal of ammonia, a byproduct of intense exercise that contributes to fatigue. The two most common forms found in supplements are L-citrulline and citrulline malate.

L-Citrulline: The Purest Form

L-citrulline is the pure, standalone amino acid. It is the most direct way to supplement the active ingredient responsible for raising nitric oxide levels. For those whose primary goal is to maximize the "pump" feeling during resistance training, L-citrulline is often the preferred choice due to its high concentration. Because you are getting 100% pure citrulline per gram, less total product may be needed compared to citrulline malate to achieve the same amount of the active amino acid.

Benefits of L-Citrulline:

  • Enhanced Muscle Pumps: By converting efficiently to L-arginine and then nitric oxide, pure L-citrulline excels at maximizing blood flow to muscles.
  • Cardiovascular Health: Research suggests L-citrulline can support healthy blood vessel function and may help lower blood pressure, especially in individuals with existing conditions.
  • Better Absorption: L-citrulline is absorbed more effectively by the body than L-arginine, making it a more consistent and potent way to boost blood flow.

Citrulline Malate: The Performance Compound

Citrulline malate is a compound made by binding L-citrulline with malic acid, a compound found in fruits like apples. The malic acid is believed to offer additional performance benefits related to energy production. It plays a role in the Krebs cycle, a process that creates cellular energy (ATP), which could help combat fatigue during long or intense workouts. This synergistic effect makes citrulline malate a popular choice for endurance athletes and those performing high-volume training.

Benefits of Citrulline Malate:

  • Improved Endurance: The addition of malic acid may help increase aerobic capacity and energy production, allowing for longer and more sustained performance.
  • Reduced Fatigue: By aiding in ATP production and waste removal, citrulline malate can help delay the onset of muscular fatigue.
  • Reduced Muscle Soreness: Studies have shown that citrulline malate can significantly reduce post-exercise muscle soreness, known as DOMS.

L-Citrulline vs. Citrulline Malate: Comparison Table

Feature / Benefit L-Citrulline Citrulline Malate
Composition Pure L-citrulline amino acid L-citrulline bound to malic acid
Citrulline Content 100% active ingredient per gram Approximately 50-70% citrulline per gram (e.g., 2:1 ratio)
Primary Benefit Maximizes muscle pumps and blood flow Boosts endurance and reduces fatigue
Supports Energy Production No direct effect via malic acid Yes, malic acid supports ATP synthesis
Best For Strength training, bodybuilders, vascularity Endurance sports, high-intensity intervals, cross-training
Considerations May require specific amounts for desired effects May require specific amounts based on citrulline ratio for desired effects

Making the Right Choice: Which Form is Best for You?

When deciding which form of citrulline is best, it comes down to your primary fitness objectives. For bodybuilders or individuals who are most concerned with maximizing muscle pumps and vascularity during their workouts, pure L-citrulline is arguably the most efficient option. This is because you can achieve a higher concentration of the active nitric oxide-boosting ingredient per gram.

However, for endurance athletes, cross-trainers, or anyone seeking to delay fatigue and increase their overall work capacity during long or intense sessions, citrulline malate may be the superior choice. The synergistic effect of malic acid in energy production provides an added benefit that L-citrulline alone lacks.

It is also worth considering cost. Citrulline malate is often less expensive per gram than pure L-citrulline. If you're on a budget and your main goal is enhancing overall performance, citrulline malate offers a cost-effective solution with a broader range of benefits due to the malic acid component. For those who prioritize a clean, pure supplement, L-citrulline provides exactly what is advertised without any additional compounds.

Practical Tips for Supplementation

  • To potentially maximize effects, consider consuming your citrulline supplement before your workout.
  • Begin with a lower amount to assess your tolerance.
  • Pay attention to the citrulline-to-malate ratio in citrulline malate products. A 2:1 ratio is standard, but some products may contain less active ingredient.
  • Consider your overall supplement plan. If your pre-workout already contains other energy-boosting ingredients, pure L-citrulline might be a better choice to focus solely on nitric oxide production.
  • For more information on the efficacy and safety of citrulline, refer to expert resources. For instance, Examine.com offers comprehensive data on supplement research.

Conclusion

Ultimately, there is no single "best" form of citrulline; the optimal choice depends entirely on your training goals. If your primary objective is to maximize muscle pumps and vascularity, pure L-citrulline is likely the most direct and potent option. Conversely, if you are focused on improving muscular endurance and combating fatigue during longer, higher-volume workouts, the added benefits of malic acid in citrulline malate make it an excellent choice. By understanding the distinct advantages of each form, you can make an informed decision to better support your athletic performance and recovery.

Frequently Asked Questions

The main difference is the addition of malic acid. L-citrulline is the pure amino acid, while citrulline malate is a compound of L-citrulline and malic acid, which supports energy production.

L-citrulline is generally considered better for maximizing muscle pumps because it provides a higher concentration of pure citrulline per gram, leading to a more potent nitric oxide boost.

Yes, citrulline malate is often preferred for endurance athletes. The added malic acid can help with cellular energy production (ATP), which contributes to reduced fatigue during prolonged exercise.

To get an equivalent amount of pure citrulline, a higher total amount of citrulline malate may be needed compared to L-citrulline.

For general health benefits, consistent daily use may be considered. For performance, consuming it before exercise is common.

Yes, studies have shown that supplementing with citrulline can reduce post-exercise muscle soreness, with citrulline malate showing significant effects in research.

While not necessary, some individuals might use both. It is more common to stick with one form based on your specific training goals to ensure proper supplementation.

Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.