Tag: Glycine toxicity

Glycine encephalopathy, more commonly known as nonketotic hyperglycinemia (NKH), is a rare metabolic disorder affecting approximately 1 in 76,000 newborns and causing a toxic accumulation of glycine in the body. Managing glycine toxicity depends heavily on its root cause, whether it is a chronic genetic issue like NKH or an acute event from medical procedures.

While glycine is generally considered safe in moderate dietary amounts, excessive levels can lead to a range of adverse effects, from mild digestive upset to severe neurological issues. The symptoms of too much glycine depend heavily on whether the high levels are from acute exposure or a genetic metabolic condition like nonketotic hyperglycinemia.

Affecting at least 1 in 76,000 newborns worldwide, nonketotic hyperglycinemia is a rare but severe genetic disorder where abnormally high glycine levels accumulate in the body. Here, we detail exactly what happens if glycine is too high, the serious health implications, and distinguish these from less severe issues caused by excess supplementation.

While glycine is generally considered safe and well-tolerated in moderate amounts for most healthy adults, adverse effects can occur, particularly with high doses or in sensitive individuals. Understanding **what are the negative effects of glycine** is crucial for anyone considering supplementation, as risks escalate significantly in certain medical contexts.