Tag: Hyperglycinemia

According to the National Organization for Rare Disorders, nonketotic hyperglycinemia (NKH) is a genetic disorder causing an accumulation of glycine, leading to severe neurological problems. This serious condition is just one of the ways that high glycine levels can manifest, with symptoms varying dramatically depending on age, cause, and severity.

High glycine levels, a condition known as hyperglycinemia, is a hallmark symptom of the rare genetic disorder nonketotic hyperglycinemia (NKH). While this specific metabolic disorder is serious and requires professional medical management, other factors can also influence glycine levels, necessitating various approaches to address them effectively.

While glycine is generally considered safe in moderate dietary amounts, excessive levels can lead to a range of adverse effects, from mild digestive upset to severe neurological issues. The symptoms of too much glycine depend heavily on whether the high levels are from acute exposure or a genetic metabolic condition like nonketotic hyperglycinemia.

Affecting at least 1 in 76,000 newborns worldwide, nonketotic hyperglycinemia is a rare but severe genetic disorder where abnormally high glycine levels accumulate in the body. Here, we detail exactly what happens if glycine is too high, the serious health implications, and distinguish these from less severe issues caused by excess supplementation.

A typical human diet provides about 2 grams of glycine daily, a level generally considered safe. However, excessive intake through supplements or genetic disorders can lead to an array of adverse reactions, highlighting the importance of understanding the symptoms of too much glycine.