Tag: Nonketotic hyperglycinemia

Glycine encephalopathy, more commonly known as nonketotic hyperglycinemia (NKH), is a rare metabolic disorder affecting approximately 1 in 76,000 newborns and causing a toxic accumulation of glycine in the body. Managing glycine toxicity depends heavily on its root cause, whether it is a chronic genetic issue like NKH or an acute event from medical procedures.

According to the National Organization for Rare Disorders, nonketotic hyperglycinemia (NKH) is a genetic disorder causing an accumulation of glycine, leading to severe neurological problems. This serious condition is just one of the ways that high glycine levels can manifest, with symptoms varying dramatically depending on age, cause, and severity.

While glycine is generally considered safe in moderate dietary amounts, excessive levels can lead to a range of adverse effects, from mild digestive upset to severe neurological issues. The symptoms of too much glycine depend heavily on whether the high levels are from acute exposure or a genetic metabolic condition like nonketotic hyperglycinemia.

Affecting at least 1 in 76,000 newborns worldwide, nonketotic hyperglycinemia is a rare but severe genetic disorder where abnormally high glycine levels accumulate in the body. Here, we detail exactly what happens if glycine is too high, the serious health implications, and distinguish these from less severe issues caused by excess supplementation.

High glycine levels, a condition known as hyperglycinemia, are most commonly associated with rare, severe inherited metabolic disorders like Nonketotic Hyperglycinemia (NKH). Therefore, understanding **how to lower high glycine?** is a medical process that goes beyond simple dietary adjustments and must be managed under expert medical supervision.