What is Nattokinase?
Nattokinase is classified as a serine protease enzyme. It originates from natto, a Japanese food produced through the fermentation of soybeans using the bacterium Bacillus subtilis. The fermentation process is key to the creation of nattokinase and its associated properties. Nattokinase powder is a purified form of this enzyme, offering a concentrated source of its potential benefits without requiring the consumption of natto itself.
Exploring Potential Health Benefits
Research has investigated nattokinase for a variety of health applications, examining its impact on different bodily systems.
Supporting Blood Circulation
One area of study for nattokinase is its effect on blood components. It has demonstrated fibrinolytic activity, meaning it can interact with fibrin, a protein involved in the blood clotting process. By influencing fibrin, nattokinase is being studied for its potential role in supporting healthy blood flow.
- Impact on Blood Clotting Factors: Clinical studies have investigated how nattokinase supplementation might influence levels of certain blood-clotting factors, suggesting a potential role in maintaining a balanced coagulation profile.
- Potential for Improved Flow: The ability to interact with fibrin is thought to contribute to enhanced circulation throughout the body.
Investigating Effects on Blood Pressure
Nattokinase has been a subject of study regarding its potential to help manage blood pressure. Some research suggests this may be partly due to interactions similar to those of angiotensin-converting enzyme (ACE) inhibitors.
Research into Cholesterol Management
The potential role of nattokinase in managing cholesterol levels has also been explored in clinical studies. A study published in 2017 examined daily nattokinase supplementation over 26 weeks and reported observations related to atherosclerosis and lipid profiles in individuals with hyperlipidemia. The study indicated potential changes in total cholesterol, LDL-C, and triglycerides, alongside potential increases in HDL-C levels.
Emerging Areas of Research
Beyond traditional focus areas, newer research is exploring other potential effects of nattokinase.
Potential Neuroprotective Properties
Research is starting to investigate if nattokinase could offer protective effects for brain health.
- Amyloid Plaque Studies: In vitro and animal studies have looked into whether nattokinase can interact with amyloid fibrils, which are protein formations associated with certain neurodegenerative conditions. The idea is that by potentially influencing these structures, nattokinase might play a role in supporting cognitive function.
- Stroke Recovery Research: Some animal studies have explored the impact of nattokinase on neurogenesis and cognitive recovery following a stroke. This potential effect is hypothesized to be linked to its influence on blood flow and inflammatory responses in the brain.
Other Possible Health Impacts
The enzyme's properties may have broader implications for health.
Supporting Respiratory Function
For individuals with chronic sinusitis, nattokinase is being explored for its potential to help with mucus consistency and the size of nasal polyps. Its interaction with fibrin, which is also present in nasal polyps, is thought to potentially improve airflow and reduce discomfort.
Gut Health Connections
As a product derived from fermentation, natto contains beneficial probiotics for the gut microbiome. While nattokinase is an isolated enzyme, the fermentation process contributes to its characteristics. A healthy gut microbiome is widely recognized for its importance in digestive health, metabolism, and immune system function.
Anti-inflammatory and Antioxidant Research
Some research associates the effects of nattokinase with reductions in inflammation and oxidative stress. Chronic inflammation is understood to be a factor in many health issues, including cardiovascular concerns, making this area of study potentially significant.
Nattokinase Powder Compared to Whole Natto
| Feature | Nattokinase Powder | Whole Natto (Fermented Soybeans) |
|---|---|---|
| Form and Ease | Typically tasteless/odorless, simple to use. | Distinctive taste, sticky texture, requires eating a food. |
| Enzyme Content | Often standardized to a specific activity (FU) for consistency. | Varies based on the fermentation batch and serving size. |
| Accompanying Nutrients | Primarily the enzyme; composition may vary by product. | Contains a broad spectrum of vitamins, minerals, and probiotics. |
| Vitamin K2 Content | High-quality supplements often have vitamin K2 removed. | Contains significant levels of vitamin K2. |
| Allergy Profile | Derived from soy, so potential for allergic reaction exists, though possibly reduced compared to the whole food. | Contains soy, carrying a higher potential risk for individuals with soy allergies. |
Important Considerations Before Use
While generally considered safe for many individuals, nattokinase may not be suitable for everyone. Individuals currently taking medications that affect blood clotting should consult with a healthcare provider before using nattokinase, as there is a potential for increased risk related to bleeding. It is also typically recommended to stop using nattokinase a couple of weeks before any planned surgical procedures. Due to limited safety data, it is generally advised that pregnant or breastfeeding women avoid nattokinase.
Using Nattokinase Powder
Nattokinase powder is usually taken orally. For optimal absorption, some sources suggest taking it on an empty stomach. The powder can be easily mixed into liquids like water, juice, or smoothies. It is important to follow the directions provided by the product manufacturer unless a healthcare professional offers alternative guidance.
Conclusion
As an enzyme with documented effects on blood components and other bodily systems, nattokinase powder presents a range of potential benefits, particularly in areas related to circulation and overall wellness. Its suggested influence on brain function and respiratory health further indicates its diverse applications. While it is a natural product of interest, understanding potential interactions with medications and observing safety recommendations are essential. For those exploring natural supplements to support their health, nattokinase powder represents an option worth discussing with a healthcare professional. For deeper scientific information on nattokinase, resources like the NCBI database offer comprehensive reviews(https://pmc.ncbi.nlm.nih.gov/articles/PMC6043915/).
