Understanding What are the Side Effects of RYSE Supplements?

October 22, 2025 •

3 min read

With the rise in popularity of performance enhancers, many fitness enthusiasts are curious about their safety and tolerability. Understanding what are the side effects of RYSE products, a popular supplement brand, is a critical step for consumers aiming for safe and effective supplementation. This guide will detail the potential adverse reactions associated with RYSE's most common offerings, such as pre-workouts and protein powders.

Quick Summary

This article explores the potential adverse effects of RYSE supplements, including caffeine-related jitters, beta-alanine tingles, and digestive discomfort, depending on the product.

Key Points

Stimulant Overload: High caffeine doses in RYSE pre-workouts can cause jitters, anxiety, and increased heart rate, especially for sensitive users.
Beta-Alanine Tingles: The harmless, pins-and-needles sensation (paresthesia) is a common side effect from beta-alanine in pre-workouts.
Digestive Distress: Both pre-workout and protein products may cause nausea, cramps, or diarrhea in individuals with sensitive digestive systems.
Know Your Limits: Mitigate side effects by starting with a half-scoop of pre-workout to assess your personal tolerance.
Follow Age Restrictions: RYSE products are intended for healthy adults 18+, and caution is advised for minors or those with existing health conditions.
Be Mindful of Warnings: Some RYSE products carry a California Proposition 65 warning regarding potential chemical exposure, including lead.
Consider Non-Stimulant Options: For those avoiding caffeine, RYSE offers non-stimulant products like Pump Daddy to enhance performance safely.

Common Side Effects of RYSE Pre-Workout

RYSE pre-workout products, like Loaded Pre and Godzilla Pre, aim to boost energy, focus, and pump but can cause side effects due to ingredients like caffeine and beta-alanine.

The High Caffeine Content

High caffeine levels are a common cause of side effects in RYSE pre-workouts, with some containing 350-400mg per serving. This can lead to:

Jitters and anxiety: Common reactions for those sensitive to stimulants.
Increased heart rate: High caffeine can elevate heart rate and may cause palpitations.
Insomnia: Taking stimulant pre-workouts late can disrupt sleep.
Headaches: Dehydration, potentially linked to some ingredients, can cause headaches.

Beta-Alanine and Paresthesia (The Tingle)

The tingling sensation, paresthesia, is a harmless, temporary side effect of beta-alanine present in RYSE pre-workouts. It's caused by nerve stimulation and is not an allergic reaction; higher doses may increase this effect.

Digestive Issues

Digestive problems like nausea, cramps, or diarrhea have been reported by some users. These issues might be linked to high caffeine, artificial sweeteners, or other ingredients. Staying hydrated and avoiding taking it on an empty stomach can help.

Side Effects of RYSE Protein Powder

RYSE protein powders generally have fewer and milder side effects, mostly related to digestive sensitivity.

Digestive discomfort: RYSE Loaded Protein, containing whey isolate and concentrate along with ingredients like MCT oil and prebiotic fiber, can cause irritation, bloating, or stomach upset for those with sensitive digestive systems.

Important Safety Considerations

Several safety points apply to all RYSE products.

Age Restrictions and Warnings

RYSE products are for healthy adults aged 18 or older. They are not suitable for minors, pregnant or nursing women, or individuals with health conditions, who should consult a doctor.

California Proposition 65 Warnings

Some RYSE products include a California Proposition 65 warning, indicating the potential presence of certain chemicals, including lead. This is a standard notification and doesn't necessarily mean the product is unsafe when used as directed.

Lack of Third-Party Testing Transparency

RYSE states products are tested internally and made in FDA-regulated facilities but does not widely publicize third-party testing. This means consumers rely on company claims regarding purity and label accuracy. Competitive athletes needing banned-substance verification should note this.

How to Mitigate Potential Side Effects

Reduce potential adverse reactions by following these tips.

Start with a lower dose: Begin with a half-scoop of pre-workout to gauge tolerance.
Stay hydrated: Drink plenty of water to prevent headaches and stomach issues.
Time your dose: Take stimulant pre-workouts earlier in the day to avoid sleep disruption.
Consider non-stim options: RYSE offers non-stimulant products for those sensitive to caffeine.
Monitor your body: Stop use if you experience severe or lasting negative symptoms.

Comparison Table: RYSE Pre-Workout vs. Protein Side Effects


Aspect	RYSE Pre-Workout (e.g., Loaded, Godzilla)	RYSE Protein Powder (e.g., Loaded Protein)
Primary Cause	High caffeine, beta-alanine, stimulants	Dairy (whey concentrate), MCT oil, sweeteners
Reported Side Effects	Jitters, anxiety, increased heart rate, insomnia, headaches, tingling (paresthesia), digestive upset (nausea, diarrhea)	Minor digestive discomfort, bloating for sensitive individuals
Severity	Can range from mild tingling to more significant stimulant-related issues depending on dosage and individual tolerance	Generally mild and limited to digestive tract
Mitigation	Start with small doses, time intake, hydrate, switch to non-stimulant options	Consider a whey isolate or plant-based protein alternative if sensitive to dairy

Conclusion

Understanding what are the side effects of RYSE is key for users. While generally safe for healthy adults, pre-workouts have a higher risk of jitters, increased heart rate, and digestive issues due to high stimulant content. Protein powders are milder, with potential discomfort for those with digestive sensitivities. Always follow dosage instructions, assess your tolerance, and consult a doctor if you have health concerns. Informed decisions and preventative steps allow for safer use of RYSE supplements. For more on supplement safety, see the Verywell Health guide: Are Pre-Workout Supplements Safe?.

Frequently Asked Questions

Yes, due to the high levels of caffeine (some products contain 350-400mg), RYSE pre-workout can cause anxiety, jitters, and a feeling of overstimulation, especially in those with a lower caffeine tolerance.

Yes, the tingling or itching sensation is a normal and harmless side effect of beta-alanine, an ingredient in many RYSE pre-workouts. It is called paresthesia and occurs as the beta-alanine stimulates nerve endings.

Stomach upset can occur due to several factors, including the high stimulant content, artificial sweeteners, or other ingredients like MCT oil in some RYSE products. Taking the supplement with water and not on an empty stomach may help reduce gastrointestinal distress.

Yes, the stimulants in RYSE pre-workout, primarily caffeine, can increase your heart rate. Individuals with a high sensitivity to caffeine may experience a racing heart or palpitations.

If taken too close to bedtime, the high caffeine content in RYSE pre-workouts can interfere with your sleep cycle and cause insomnia. It's best to take stimulant products earlier in the day to allow time for the caffeine to wear off.

No, RYSE explicitly states that its products are intended for healthy adults 18 years of age and older. High stimulant and potent ingredients are not recommended for minors.

For most people, RYSE protein powder is well-tolerated. However, for those with a dairy sensitivity, the whey concentrate and MCTs can potentially cause bloating or digestive irritation.

Yes, RYSE offers non-stimulant pre-workout alternatives, such as their Pump Daddy product, which provides performance benefits without the high caffeine content.