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What are the diseases caused by calorie malnutrition?

4 min read

According to the World Health Organization, nearly half of all deaths among children under 5 are linked to undernutrition, a severe form of malnutrition. This fact underscores the critical importance of understanding what are the diseases caused by calorie malnutrition and their profound impact on global health.

Quick Summary

Severe undernutrition resulting from an overall lack of calories can lead to life-threatening conditions like marasmus and kwashiorkor, causing muscle wasting, stunted growth, weakened immunity, and organ damage.

Key Points

  • Two Primary Forms: Calorie malnutrition most severely manifests as marasmus (wasting) or kwashiorkor (edema), with a mixed form also possible.

  • Wasting (Marasmus): A deficiency of all macronutrients, leading to severe muscle and fat loss, giving a visibly emaciated appearance.

  • Edema (Kwashiorkor): A lack of protein, despite some calorie intake, causes fluid retention, leading to a distended belly and swollen extremities.

  • Systemic Complications: Both conditions severely weaken the immune system, increase the risk of infections, and can cause organ damage, stunted growth, and developmental delays.

  • Associated Deficiencies: Calorie malnutrition often coincides with deficiencies in micronutrients like iron (leading to anemia) and vitamin D (causing rickets).

  • Refeeding Risk: Treatment must be cautious, as too-rapid reintroduction of nutrients can cause refeeding syndrome, a potentially fatal metabolic complication.

  • Impact on Children: Infants and young children are particularly vulnerable, with lasting physical and mental disabilities if not treated promptly.

In This Article

Understanding Calorie Malnutrition

Calorie malnutrition, more formally known as protein-energy malnutrition (PEM), is a critical condition resulting from a severe deficiency in energy and protein intake. It is not merely hunger but a complex series of physiological adaptations the body undergoes to survive starvation. This process involves breaking down its own tissues for energy and shutting down non-essential functions, which can have long-lasting and often irreversible health consequences. While typically associated with resource-limited countries, PEM can also occur in developed nations due to underlying illnesses, neglect, or eating disorders. The two most severe forms of PEM are kwashiorkor and marasmus, though they can also manifest as a combined state known as marasmic-kwashiorkor.

Marasmus: The Wasting Syndrome

Marasmus, derived from the Greek word for 'withering,' is a type of severe undernutrition caused by a deficiency in all macronutrients—carbohydrates, fats, and protein. This is the body's adaptive response to starvation, where it catabolizes its own fat and muscle tissues to provide energy, resulting in a profoundly emaciated appearance. Children with marasmus appear visibly depleted, with a prominent skeleton and a wrinkled, loose skin that hangs in folds.

Symptoms and signs of marasmus often include:

  • Severe weight loss, leading to a low body mass index (BMI).
  • Visible wasting of fat and muscle, especially in the buttocks, thighs, and face, giving an 'old man' or 'monkey-like' facies.
  • Stunted growth and developmental delays in children.
  • Dry, brittle hair and skin.
  • Lethargy, apathy, and weakness.
  • Low body temperature, heart rate, and blood pressure as the body conserves energy.
  • A compromised immune system, increasing susceptibility to infections.

Kwashiorkor: The Edematous Malnutrition

Kwashiorkor, a name from the Ga language meaning 'the sickness the baby gets when the new baby comes,' describes a condition primarily resulting from a protein deficiency in a diet that may still have adequate calories, often from carbohydrates. It typically occurs in older infants and children who have been weaned from breast milk and fed a starchy, low-protein diet. A key distinguishing feature is the presence of edema, or fluid retention, which can cause swelling in the ankles, feet, and face, and a distended belly.

Common signs of kwashiorkor include:

  • Bilateral pitting edema, which can mask actual weight loss.
  • An enlarged, fatty liver (hepatomegaly).
  • Changes in hair and skin pigmentation, with hair becoming thin, brittle, and reddish.
  • Skin lesions, rashes, and peeling.
  • Irritability and apathy.
  • A weakened immune system, making infections more likely.

The Spectrum of Protein-Energy Malnutrition

Some cases of malnutrition present with symptoms of both kwashiorkor and marasmus. This combined form is known as marasmic-kwashiorkor and represents the most severe manifestation of PEM. Affected individuals show severe wasting along with edema and have the worst prognosis. Additionally, calorie malnutrition often co-occurs with various micronutrient deficiencies, which can lead to specific diseases:

  • Anemia: Iron deficiency is common, leading to fatigue, weakness, and impaired cognitive function. Deficiencies in Vitamin B12 and folate can also cause different types of anemia.
  • Rickets and Osteoporosis: Lack of vitamin D and calcium can lead to softened, weak bones in children (rickets) and brittle bones in adults (osteoporosis).
  • Infections: A suppressed immune system makes malnourished individuals highly vulnerable to severe and chronic infections like infectious diarrhea, pneumonia, and measles.
  • Cognitive and Developmental Impairment: Inadequate nutrition, especially in early life, can lead to stunted growth, developmental delays, and permanent cognitive deficits.

Comparing Marasmus and Kwashiorkor

Feature Marasmus Kwashiorkor
Primary Deficiency Severe lack of all macronutrients (calories, protein, fat). Predominant protein deficiency with relative carbohydrate adequacy.
Characteristic Sign Severe muscle and fat wasting, emaciation. Bilateral pitting edema (fluid retention).
Appearance Wasted, shrunken appearance, loose skin folds. Puffy face, distended abdomen, thin arms and legs.
Prognosis Better prognosis than kwashiorkor if treated early. Higher mortality rate, especially with delayed treatment.
Fatty Liver Generally not present until late stages. Distinctive presence of an enlarged, fatty liver.
Mental State Apathetic but can be alert; some may be ravenously hungry. Markedly irritable and apathetic, poor appetite.

Conclusion

Calorie malnutrition, in its severe forms of marasmus and kwashiorkor, represents a dire medical emergency with profound systemic consequences. These conditions impact every organ system, from the heart and immune system to the brain and digestive tract, leading to a host of other related diseases and complications. Timely and cautious nutritional rehabilitation is critical for survival and recovery, although some physical and intellectual impairments, particularly in children, may be permanent. Preventing malnutrition requires a multifaceted approach that addresses food security, public health, and access to education. For more information on this global issue, visit the World Health Organization's website on malnutrition.

Frequently Asked Questions

The main difference is the physical manifestation: marasmus is characterized by severe muscle and fat wasting, while kwashiorkor is defined by bilateral pitting edema (swelling due to fluid retention), which can mask weight loss.

Yes, if left untreated or addressed too late, severe calorie malnutrition can lead to permanent physical and mental disabilities, especially in children, including stunted growth and cognitive impairment.

No, while more prevalent in areas of poverty and food scarcity, it can also affect individuals in developed countries due to underlying medical conditions, eating disorders like anorexia nervosa, or elder abuse and neglect.

During marasmus, the body breaks down its own fat and muscle tissue for energy, leading to a severely emaciated appearance. It also slows vital functions like heart rate and body temperature to conserve energy.

Kwashiorkor causes a swollen belly and edema due to a severe protein deficiency. The lack of proteins, particularly albumin, disrupts the body's fluid balance, causing fluid to accumulate in tissues and the abdominal cavity.

Yes, calorie malnutrition is often accompanied by other health issues, including anemia (due to iron or other vitamin deficiencies), weakened immunity, organ failure, and gastrointestinal problems.

Severe malnutrition must be treated carefully, often in a hospital setting. Treatment involves cautious rehydration, addressing electrolyte and micronutrient deficiencies, and gradually reintroducing calorie and protein-rich formulas to prevent refeeding syndrome.

References

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.