What are the Side Effects of Collagen Glow Shakes?

November 20, 2025 •

4 min read

According to a 2022 review, while many collagen supplements are generally well-tolerated, some individuals may experience mild side effects, such as digestive discomfort. Before jumping on the trend, it is crucial to understand what are the side effects of collagen glow shakes to ensure they are the right choice for your body and health needs.

Quick Summary

This article explores the potential adverse effects associated with collagen glow shakes, including common digestive problems, allergic reactions, and interactions with certain medications. It also outlines who should exercise caution and offers practical advice on choosing safer, high-quality supplements.

Key Points

Digestive Issues: Collagen shakes can cause side effects like bloating, gas, heartburn, and an upset stomach, particularly in sensitive individuals or with high doses.
Allergic Reactions: Those with allergies to beef, fish, or shellfish should be cautious, as these are common collagen sources and can trigger allergic reactions.
Kidney Health Concerns: Excessive protein from collagen, particularly its hydroxyproline content, may increase the risk of kidney stones in susceptible individuals.
Medication Interactions: There is some evidence that a high-protein diet from collagen supplements can interfere with certain blood pressure medications.
Check for Contaminants: Unregulated supplements may contain heavy metals; choose reputable brands that offer third-party testing to ensure product purity.
Hypercalcemia Risk: Some marine-sourced collagen can be high in calcium, potentially leading to excessive calcium levels in the blood, which can cause nausea and fatigue.
Histamine Intolerance: As collagen is naturally high in histamine, individuals with an intolerance may experience headaches, fatigue, or hives.

Common Digestive Problems from Collagen Shakes

Many people introduce collagen glow shakes into their routine for potential beauty and health benefits, but some may experience gastrointestinal distress. Digestive issues are among the most frequently reported side effects associated with collagen supplements. The severity can range from mild discomfort to more significant problems, often influenced by the supplement's formulation and the individual's sensitivity. Common symptoms include:

Bloating and gas
Feelings of fullness or heaviness in the stomach
Diarrhea or constipation
Nausea

These problems can arise for a few key reasons. First, some supplements contain chemical additives or flavourings that can irritate the digestive tract. Second, the digestibility of the collagen can be a factor. While most powdered collagen is hydrolyzed (broken down into smaller, easier-to-absorb peptides), some less refined forms or high doses can be difficult for the body to process, leading to bloating and other symptoms. To mitigate these issues, it is often recommended to start with a low dose and gradually increase it, or to take the supplement with food.

Allergic Reactions and Sensitivities

Collagen is derived from animal sources such as bovine (cows), marine (fish and shellfish), or porcine (pigs) origins. For individuals with allergies to any of these sources, consuming a collagen glow shake can trigger an allergic reaction. Although rare, these reactions can vary in severity and may include:

Skin rashes, redness, or itching
Swelling of the lips, tongue, or face
Hives
In severe cases, anaphylaxis

It is crucial for those with known allergies to carefully check the product label for the collagen's source before consuming. An allergy to fish or shellfish, for instance, means marine-based collagen is off-limits. Furthermore, some people report developing skin breakouts or acne after taking collagen, which may be related to an intolerance or the presence of other ingredients and preservatives in the shake formula.

Potential for Kidney Stones and Hypercalcemia

One of the more serious potential side effects is the risk of developing kidney stones. Collagen is rich in an amino acid called hydroxyproline. During metabolism, hydroxyproline can be converted into oxalate, a substance that, when in high concentrations, can contribute to the formation of kidney stones. While this is not a concern for most individuals, those with a history of kidney stones or kidney disease should consult a doctor before starting a collagen supplement. Proper hydration is also essential for anyone taking collagen to help prevent this buildup.

Another related risk is hypercalcemia, an excessive accumulation of calcium in the blood. This can happen if the collagen supplement is also high in calcium, as some marine-sourced products can be. Symptoms of hypercalcemia include nausea, vomiting, fatigue, and weakness.

Interactions with Medications and Health Conditions

Collagen glow shakes are dietary supplements, and as such, they may not be suitable for everyone. While no major drug interactions are widely known, caution is warranted. For example, studies suggest that a high-protein diet (which includes collagen) might affect the metabolism of certain blood pressure medications, such as propranolol and warfarin. Therefore, individuals on medication, especially for chronic conditions, should always consult their healthcare provider before introducing a collagen shake into their diet.

Comparison of Collagen Side Effects by Source


Potential Side Effect	Bovine Collagen (Cows)	Marine Collagen (Fish/Shellfish)	Plant-Based 'Collagen Boosters'
Allergy Risk	Risk for those with beef allergies.	Risk for those with fish or shellfish allergies.	Minimal allergic risk related to the protein source itself, but depends on other ingredients.
Taste Issues	Can have a milder, more neutral taste.	Some users report a residual fishy aftertaste.	Taste varies significantly based on plant ingredients and flavorings.
Digestive Issues	Can cause bloating, gas, or stomach heaviness in some individuals.	Similar to bovine collagen, depends on hydrolyzation and dosage.	Dependent on ingredients like protein sources, fiber, and added sweeteners.
Sustainability	Sourcing methods can vary; some are pasture-raised.	Often sourced from fish skins, a byproduct of the seafood industry.	Varies widely based on specific plant ingredients and farming practices.

Long-Term Health Risks and Other Considerations

Limited long-term studies exist on the effects of collagen supplements, and most existing research has focused on short-term use. This makes it difficult to ascertain the full scope of any long-term health risks. Furthermore, because supplements are not regulated by the FDA in the same way as medications, product purity and potency can vary widely. Some studies have found contaminants like heavy metals (e.g., arsenic, lead, and cadmium) in certain collagen products. To minimize this risk, it is essential to choose reputable brands that conduct third-party testing.

Lastly, some individuals have reported other side effects, though less common. These can include a bad taste in the mouth or changes in mood. For those with histamine intolerance, the high natural histamine content in some collagen products can trigger adverse reactions like headaches, hives, and digestive upset.

Conclusion: Informed Choices are Key

While collagen glow shakes are marketed for their beauty and wellness benefits, understanding the potential side effects is vital for safe consumption. For most people, side effects are mild and may include digestive upset, but risks increase for individuals with specific allergies, pre-existing health conditions like kidney disease, or those on certain medications. Choosing a high-quality, third-party tested product and consulting with a healthcare provider can help minimize risks. By considering these factors, you can make an informed decision about whether collagen glow shakes are right for your body.

For more information, please consult the National Institutes of Health regarding dietary supplements: NIH Dietary Supplement Information.

Frequently Asked Questions

Common digestive issues include bloating, gas, feelings of fullness, and changes in bowel movements like diarrhea or constipation. These can be caused by the supplement's ingredients, dosage, or an individual's sensitivity.

Yes, allergic reactions can occur, especially if you have allergies to the animal sources used to make the collagen (e.g., fish, beef, or shellfish). Symptoms can range from skin rashes and swelling to more severe reactions.

There is a potential risk, particularly for those with a history of kidney stones. Collagen contains hydroxyproline, which can be converted to oxalate, a contributor to kidney stone formation. Staying well-hydrated is crucial if you take collagen.

While major interactions are rare, some studies suggest that high-protein intake from supplements may affect the efficacy of certain blood pressure medications. It is always best to consult your doctor before starting any new supplement if you are on medication.

To minimize risks, start with a low dose, take it with food, and choose a high-quality product from a reputable brand that provides third-party testing results. Also, be aware of the collagen source to avoid allergens.

Look for products that are third-party tested for purity and potency to avoid potential contaminants like heavy metals. Read the label to understand the collagen source and any additional ingredients.

Individuals with allergies to collagen sources, those with a history of kidney stones or kidney disease, and pregnant or breastfeeding women should exercise caution. Always consult a healthcare provider if you have any pre-existing health conditions.