Lactose, the primary carbohydrate in milk
Lactose is a disaccharide, or double sugar, with the chemical formula $C{12}H{22}O_{11}$. It is formed by the condensation reaction of two simpler sugar molecules: one glucose molecule and one galactose molecule, joined by a $\beta$-(1→4)-glycosidic bond. This unique structure is the reason the body requires a specific enzyme, lactase, to break it down before it can be absorbed through the intestinal wall.
The role of lactose in infant and adult nutrition
In newborn mammals, including humans, lactose is a vital source of energy, and its synthesis in the mammary gland ensures that milk provides essential nutrition. Lactose is particularly important in infants for providing galactose, a component needed for the synthesis of complex molecules like glycoproteins and glycolipids that are crucial for nervous tissue development. In addition to its role as an energy source, lactose has other beneficial effects, such as promoting the absorption of minerals like calcium and magnesium, which are essential for bone health.
For adults who possess the genetic trait known as lactase persistence, lactose digestion continues into adulthood, allowing for the consumption of dairy products without adverse effects. However, a significant portion of the global population experiences a natural decline in lactase production after weaning, leading to lactose malabsorption and the symptoms of lactose intolerance.
Lactose in the food and pharmaceutical industries
Beyond its role in natural milk, lactose is a versatile and widely used ingredient in manufacturing. It is produced industrially from whey, a byproduct of the cheese-making process, and its physical properties make it ideal for various applications.
- Sweetener: Lactose has a mild sweetness, only about 20-40% as sweet as sucrose, making it useful for increasing the bulk of a product without adding excessive sweetness. It is often used in confectionery, baked goods, and beer production, particularly stouts and porters.
- Texturizer: In ice cream, it affects the freezing point and contributes to a smoother texture. In condensed milk, controlled crystallization of lactose prevents a gritty mouthfeel.
- Carrier and excipient: In the pharmaceutical industry, purified lactose acts as an inactive filler, binder, or carrier in tablets, capsules, and dry powder inhalers, aiding in the delivery of active ingredients. Its stability and compatibility with other substances make it a preferred excipient.
- Browning agent: As a reducing sugar, lactose participates in the Maillard reaction, which is responsible for the browning and characteristic flavors of many baked foods.
- Fermentation substrate: Certain lactic acid bacteria ferment lactose, a process essential for making products like yogurt, kefir, and certain cheeses.
Lactose vs. other common sugars: A comparison
To better understand lactose, comparing it with other common disaccharides like sucrose and maltose provides valuable context regarding their sources, structure, and uses.
| Feature | Lactose | Sucrose | Maltose |
|---|---|---|---|
| Common Name | Milk Sugar | Table Sugar | Malt Sugar |
| Monosaccharide Components | Glucose + Galactose | Glucose + Fructose | Glucose + Glucose |
| Source | Mammalian milk | Sugar cane, sugar beets, fruits | Sprouting grains (e.g., barley) |
| Digesting Enzyme | Lactase | Sucrase | Maltase |
| Sweetness (vs. Sucrose=1) | 0.2–0.4 | 1.0 | 0.4–0.5 |
| Reducing Sugar? | Yes | No | Yes |
| Industrial Use | Pharma excipient, infant formula | Sweetener, preservative | Brewing, food flavoring |
Managing lactose intolerance
For individuals with lactose intolerance, managing the condition typically involves dietary changes to limit lactose intake. The severity of symptoms, such as bloating, diarrhea, and gas, depends on the amount of lactose consumed and the individual's remaining lactase activity. Many people can tolerate small amounts of lactose, especially if consumed with other foods. Aged, hard cheeses and many fermented products often have lower lactose content due to the fermentation process. Lactase enzyme supplements are also widely available to help break down lactose in dairy products. However, individuals with a true milk allergy, an immune reaction to milk proteins, must avoid all dairy, including lactose-free alternatives.
The importance of dairy nutrients
When considering reducing or eliminating lactose, it is important to ensure that the diet still provides sufficient nutrients like calcium, vitamin D, and protein, especially for adolescents and pregnant women. Dairy products are a major source of these nutrients, and removing them without proper substitution can lead to deficiencies. Alternative sources, such as lactose-free dairy products, fortified plant-based milks, and dietary supplements, can help maintain adequate nutritional intake. National Institute of Diabetes and Digestive and Kidney Diseases: Lactose Intolerance offers extensive information on managing lactose intolerance and maintaining a healthy diet.
Conclusion
What is lactose also known as? The simple answer is milk sugar. However, its identity is more complex, revealing a crucial disaccharide composed of glucose and galactose. Its significance extends from providing vital energy for infant growth to serving as a versatile ingredient in numerous food and pharmaceutical products. While lactose intolerance can affect quality of life, understanding its nature allows for effective management through dietary adjustments and supplemental enzymes. This comprehensive understanding highlights lactose's multifaceted role in biology, nutrition, and industry, solidifying its place far beyond just a simple milk component.