Understanding Nattokinase
Nattokinase is a potent fibrinolytic enzyme extracted from natto, a traditional Japanese food made from fermented soybeans. The fermentation process, which uses a specific bacteria known as Bacillus subtilis var. natto, is what produces this unique enzyme. For thousands of years, natto has been a staple in Japanese diets and is recognized for its numerous health benefits, particularly for the heart. The enzyme works by breaking down fibrin, a protein involved in blood clot formation, which supports healthy blood flow and circulation.
The Natural Factors 100mg Formula
Natural Factors' 100mg nattokinase supplement is derived from a whole natto concentrate using fermented, non-GMO soybeans. This formula uses NSK-SD, a patented and highly purified form of nattokinase that has been successfully utilized in multiple human clinical studies. Each easy-to-take vegetarian capsule supplies 2000 FU (fibrinolytic units) of nattokinase, a standard dosage for effectiveness. One of the key features of the Natural Factors formulation is the removal of naturally occurring vitamin K2 from the final product. This is a critical safety consideration for individuals taking anticoagulant medications, as vitamin K2 can interfere with their function. The product is also vegan, gluten-free, and independently verified for purity through ISURA testing.
Health Benefits of Nattokinase
The primary health benefits associated with nattokinase from natural sources relate to cardiovascular and circulatory health. Studies have explored its impact on several key areas:
- Cardiovascular Support: By helping to break down fibrin, nattokinase supports healthy blood clotting factors within a normal range. This can help maintain a healthy circulatory system and reduce the risk factors associated with various cardiovascular issues.
- Blood Pressure Management: Research indicates that nattokinase may help support healthy blood pressure levels. Clinical studies have shown that a daily intake of 2000 FU of nattokinase over eight weeks can help reduce both systolic and diastolic blood pressure in certain individuals.
- Improved Blood Flow and Viscosity: The enzyme's fibrinolytic action can lead to improved blood flow by reducing blood viscosity. This creates an important protective mechanism against the formation of blood clots.
- Sinus Health: Some research suggests that nattokinase may improve symptoms of chronic sinusitis by shrinking nasal polyps and thinning mucus, thus promoting better airflow.
- Potential Anti-Inflammatory Effects: While more human studies are needed, preliminary research suggests nattokinase may have anti-inflammatory properties, which could benefit overall health and conditions related to chronic inflammation.
Natural Factors 100mg vs. Other Nattokinase Brands
| Feature | Natural Factors 100mg (2000 FU) | Generic Nattokinase Supplement |
|---|---|---|
| Sourcing | Fermented non-GMO soybeans, whole natto concentrate | Varies greatly, may not be whole concentrate or non-GMO |
| Enzyme Form | Patented NSK-SD, clinically studied | Often uses unstandardized or generic nattokinase |
| Vitamin K2 Removal | Vitamin K2 is removed during processing | May or may not have vitamin K2, which can interact with blood thinners |
| Testing | ISURA verified clean, third-party tested | Verification standards and testing vary by manufacturer |
| Additives | Vegan, no artificial colours, preservatives, or sweeteners | Can contain various fillers, binders, or artificial ingredients |
Important Safety Information and Side Effects
While nattokinase is generally considered safe, certain precautions are necessary. It is crucial to consult a healthcare professional before starting any new supplement, especially if you have pre-existing health conditions or are taking other medications. Some important considerations include:
Contraindications and Interactions
- Blood-thinning medications: Nattokinase should not be taken with anticoagulant or antiplatelet drugs, such as warfarin or high-dose aspirin, as it may increase the risk of excessive bleeding or bruising.
- Pre-Surgery: Discontinue nattokinase use at least two weeks before any scheduled surgery to minimize bleeding risk.
- Soy Allergy: As the product is derived from fermented soybeans, individuals with a soy allergy should avoid using it.
- Low Blood Pressure: People with naturally low blood pressure or those taking blood pressure medication should monitor their blood pressure closely, as nattokinase can lower it further.
Who Should Avoid Nattokinase
- Pregnant and breastfeeding women.
- Individuals with a bleeding disorder.
- Those with known soy allergies.
Conclusion
Nattokinase from Natural Factors 100mg is a well-regarded supplement for cardiovascular and circulatory support, featuring a clinically studied, high-purity enzyme (NSK-SD) derived from non-GMO fermented soybeans. Its formulation is specifically designed to be vitamin K2-free, offering a safer option for those on anticoagulant therapy (under medical supervision only). The product provides 2000 FU of enzyme activity per capsule, aligning with effective dosages used in clinical trials. While offering significant benefits for heart health, it is essential to be aware of the safety precautions, especially regarding interactions with blood-thinning medications and pre-operative use. As with any potent health supplement, professional medical advice is paramount before incorporating nattokinase into your regimen.
For more general information on nattokinase, including uses and risks, consult the comprehensive resource on Drugs.com, a reputable authority on pharmaceuticals and supplements.
