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What is the enzyme in pineapple that makes your mouth hurt?

3 min read

Over 28 million people in the U.S. deal with chronic sinusitis, but the uncomfortable tingling or burning sensation that many people feel after eating fresh pineapple is caused by something entirely different. This effect, often mistaken for an allergic reaction, is actually caused by the potent proteolytic enzyme known as bromelain.

Quick Summary

The burning sensation from eating pineapple is caused by bromelain, a protein-digesting enzyme that breaks down proteins in your mouth. This natural, temporary effect can be neutralized by cooking the fruit, using canned pineapple, or consuming dairy products alongside it. The irritation is harmless as your body regenerates the affected cells quickly.

Key Points

  • Culprit Enzyme: The stinging sensation from fresh pineapple is caused by bromelain, a group of proteolytic (protein-digesting) enzymes.

  • How it Hurts: Bromelain breaks down the protein-based protective mucus and delicate surface cells on your tongue, lips, and the roof of your mouth.

  • Temporary Effect: The mouth irritation is not dangerous, as your body’s cells regenerate quickly, and the effect is temporary.

  • Heat Deactivates it: Cooking, grilling, or canning pineapple destroys the bromelain enzyme, so processed pineapple won't cause the burning feeling.

  • Counteract with Dairy: Eating pineapple with a dairy product like yogurt can help, as the bromelain will act on the dairy's protein instead of your mouth tissue.

  • Highest Concentration: The pineapple's core and stem contain the highest amount of bromelain; removing the core can reduce irritation.

  • Health Benefits: The same enzyme, bromelain, is used as a dietary supplement for its anti-inflammatory and digestive properties.

In This Article

The Protein-Eating Power of Bromelain

Bromelain is not a single enzyme but rather a complex mixture of enzymes, the most prominent of which are cysteine proteases. This group of enzymes, naturally found in pineapples, performs the function of breaking down other proteins into smaller, digestible components. It is the same enzyme that is extracted and used as a commercial meat tenderizer. The powerful protein-digesting properties are beneficial for the pineapple plant itself, protecting it from insects and parasites.

When you eat fresh pineapple, the bromelain gets to work immediately on the proteins it encounters—including the delicate tissues on the inside of your mouth, tongue, and lips. The enzyme starts to break down the protective layer of mucus and surface cells, which leads to the familiar tingling, burning, or raw sensation. While this sounds alarming, it is a normal and harmless reaction, as your body quickly regenerates the cells and repairs the affected tissue.

The Role of Acidity and Other Factors

Alongside bromelain, the high acidity of pineapple also contributes to the mouth irritation. When bromelain has already started to degrade the protective mucus coating, the fruit's acid is more potent and can feel significantly more irritating. Unripe pineapples tend to have higher acid content and can cause a more pronounced burning sensation. The concentration of bromelain also differs depending on the part of the fruit. The highest concentration is found in the core and stem, with lower levels in the juicy outer flesh.

Comparing Raw vs. Processed Pineapple

Not all pineapple causes the same level of irritation. In fact, canned or cooked pineapple often presents no issue at all. This is due to the process of denaturation, where high heat permanently alters the structure of the enzyme, rendering it inactive. This is why adding fresh pineapple to a gelatin dessert (a protein) will prevent it from setting, while canned pineapple will not have this effect. The canning process utilizes heat, effectively neutralizing the bromelain.

How to Reduce the Burning Sensation

If you love fresh pineapple but hate the tingle, there are several simple tricks you can use to minimize the effect:

  • Cook the pineapple: Grilling, roasting, or baking the fruit is an effective way to destroy the bromelain and eliminate the burning sensation.
  • Pair it with dairy: Consuming pineapple with dairy products like yogurt, ice cream, or crème fraîche gives the bromelain an alternative source of protein to break down.
  • Soak in saltwater: A brief soak in saltwater can help neutralize the enzyme's activity.
  • Choose ripe fruit: Riper pineapples generally have less bromelain and are less acidic than their unripe counterparts.
  • Remove the core: Since the core has the highest concentration of the enzyme, cutting it out can significantly reduce irritation.

Table: Fresh vs. Canned Pineapple and Bromelain Activity

Feature Fresh Pineapple Canned Pineapple
Bromelain Activity High (Active) Low to None (Denatured)
Tingling/Burning Sensation Common Rare
Best for Gelatin Desserts No (will prevent setting) Yes
Primary Use Eaten raw, fresh dishes Casseroles, cooked desserts
Taste Profile More complex, often tarter Sweeter, less acidic
Nutrient Density Higher overall, especially fiber Can be lower depending on syrup

The Benefits of Bromelain

While it can be a nuisance in your mouth, bromelain offers a number of potential health benefits, which is why it is sold as a dietary supplement.

  • Anti-inflammatory properties: It is used to help reduce inflammation and swelling, particularly related to sinusitis, arthritis, and surgical trauma.
  • Digestive aid: Bromelain can assist in the digestion of proteins, and some studies suggest it may help with certain gastrointestinal issues.
  • Wound and burn treatment: Topically, bromelain can be used to remove damaged tissue from burns.

Conclusion

The burning and tingling sensation you experience when eating pineapple is a perfectly normal and harmless reaction caused by the protein-digesting enzyme, bromelain. This powerful enzyme works on the protective proteins in your mouth, creating a temporary soreness that your body quickly heals. By understanding the science behind bromelain, you can easily minimize the effect through simple preparation methods like cooking, soaking in saltwater, or enjoying it alongside dairy. This knowledge allows you to enjoy the delicious, tropical flavor of fresh pineapple without any lingering discomfort.

Potential Outbound Link

For more in-depth scientific information on bromelain's therapeutic uses and properties, you can review the extensive research on the National Center for Biotechnology Information's website.

Frequently Asked Questions

Bromelain is a complex mixture of protein-digesting enzymes found in the pineapple plant. It is what causes the tingling and burning sensation in your mouth when you eat fresh pineapple, as it begins to break down the proteins of your delicate oral tissue.

No, it is not dangerous. The sensation is temporary and harmless, as your body quickly regenerates the affected cells. It's a natural chemical reaction, not a sign of a severe problem.

Yes, cooking pineapple by grilling, baking, or boiling it will denature (deactivate) the bromelain enzymes. This is why canned pineapple, which is heat-processed, does not cause mouth irritation.

Canned pineapple does not hurt your mouth because the high heat used during the canning process destroys the active bromelain enzyme. As a result, the canned fruit cannot break down the proteins in your mouth.

You can mitigate the burning sensation by eating pineapple with dairy products like yogurt, rinsing your mouth with saltwater, or simply eating smaller quantities. Using canned or cooked pineapple is the most effective preventative method.

While it is a natural reaction to the enzyme for most, a true allergy to pineapple can cause more severe symptoms like hives, swelling, or difficulty breathing. If your reaction is beyond a temporary tingle, you should consult a doctor.

The highest concentration of bromelain is in the core and stem of the pineapple, though it is also present in the fruit's flesh. Removing the core before eating can therefore reduce the amount of enzyme you consume.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.