Monosodium L-glutamate (MSLG) is listed as an ingredient in the proprietary blend found in Amberen, a popular dietary supplement for menopause and perimenopause relief. While the common perception of MSG is that of a flavor enhancer in processed foods, its inclusion in Amberen is for different, biochemical reasons. Amberen's manufacturer clarifies that the MSLG used is a bioactive, pharmaceutical-grade compound, distinct from food-grade MSG. The presence of MSLG is a key component of the proprietary formula, designed to work alongside other ingredients to address menopausal symptoms.
The Role of Monosodium L-Glutamate in Amberen
Amberen's ingredient list confirms the inclusion of monosodium L-glutamate as part of its unique, proprietary compound. The company explains that this form of glutamate is not added for taste. Instead, it is included for its potential roles in the body's metabolic and nervous systems.
Supporting Nervous System and Metabolism
Glutamic acid, the base amino acid of MSG, is naturally found in the body and plays a crucial role in brain function and cellular metabolism. The manufacturers of Amberen claim that their specific, bioactive MSLG helps stabilize energy within the cells and supports the nervous system. By providing these foundational components, the supplement aims to address some of the underlying hormonal fluctuations that cause menopausal symptoms like mood swings, fatigue, and irritability.
An Amino Acid and Antioxidant
Amberen's proprietary blend is described as containing amino acids, minerals, and bioactive antioxidants. As a salt of the amino acid glutamic acid, MSLG falls into this category. The formula is designed to help address menopausal symptoms without introducing hormones or common botanicals like soy and black cohosh, which are often used in other supplements.
Understanding Different Grades of Glutamate
It is important for consumers to differentiate between the form of glutamate used in Amberen and the food additive with which many people are familiar. The source and processing can be quite different.
| Aspect | Amberen's Monosodium L-Glutamate | Typical Food-Grade MSG |
|---|---|---|
| Purpose | Bioactive compound to support cellular function. | Flavor enhancer, providing a savory, umami taste. |
| Quantity | Small, pharmaceutical-grade dose (e.g., 40mg per serving). | Amounts can vary widely depending on the food and recipe. |
| Production | Produced as part of a patented blend, pharmaceutical grade. | Typically produced through fermentation of starches or sugars. |
| Common Perception | Often misunderstood due to the negative stigma associated with food-grade MSG. | Frequently associated with food sensitivities, although scientific evidence is inconclusive for most. |
Addressing the MSG Controversy in Amberen
The inclusion of MSLG in Amberen is a source of concern for some consumers, particularly those who associate MSG with negative side effects. User reviews on sites like Amazon and Walmart sometimes mention headaches, jitters, or other adverse reactions, which some attribute to the MSG. The so-called "Chinese Restaurant Syndrome," a term coined in the 1960s based on anecdotal reports, helped create a negative public perception around MSG, although numerous blinded studies have failed to consistently confirm these reported reactions in the general population.
The Company's Stance on Safety
In response to consumer questions, Amberen's manufacturer, Lunada Biomedical, and retailers assert that MSG is "generally recognized as safe" (GRAS) by the U.S. Food and Drug Administration (FDA). The company further distinguishes its product by noting the use of a small, pharmaceutical-grade dose of MSLG, which is different from the quality and quantity used in many processed foods. They point to clinical studies that showed the overall formulation was well-tolerated with no reported adverse side effects during trials, though individual intolerances are possible.
Clinical Evidence and Consumer Experience
While clinical trials might show no adverse effects on average, anecdotal consumer experiences found in online reviews suggest that some individuals may experience side effects, potentially from the MSLG or other ingredients. Reported side effects can include migraines, bloating, and fatigue. This highlights the variation in individual responses to supplements and the importance of consulting a healthcare provider, especially if one is sensitive to MSG or has severe hypertension.
The Broader Formulation and Its Intended Action
Amberen’s approach to menopause relief is unique in that it avoids hormones and most common botanicals like soy and black cohosh, which are often used in other supplements. Instead, it uses a proprietary blend of succinates, amino acids, minerals, and Vitamin E. The specific blend varies slightly between the Perimenopause and Menopause Relief products but consistently includes key succinates such as ammonium succinate and calcium disuccinate, as well as glycine and monosodium L-glutamate.
This proprietary formulation is believed to work by interacting with the endocrine system to help re-activate hormone production, addressing the root cause of symptoms rather than just managing them. The manufacturer's research, including several clinical trials, suggests that this combination of ingredients can lead to significant reductions in common menopause symptoms over a 90-day period.
Conclusion: Making an Informed Decision
In summary, the reason why Amberen contains monosodium L-glutamate is not to enhance flavor, but to utilize it as a bioactive compound within its patented formula. The manufacturer contends that the small, pharmaceutical-grade dose is safe and distinct from the stigma associated with food-grade MSG. While clinical trials back the product's overall safety and efficacy, individual experiences can vary, and some sensitive users have reported adverse effects. Ultimately, a well-informed decision should take into account both the scientific data and individual health profile. For any concerns, a healthcare professional can offer personalized guidance. Additional information on MSG and other food additives can be found on the FDA website.
Food and Drug Administration: Questions and Answers on Monosodium glutamate (MSG)
