Align vs. Culturelle: A Tale of Two Strains
While both Align and Culturelle are marketed as daily probiotic supplements to support digestive health, they are fundamentally different because they rely on distinct, scientifically-backed probiotic strains to achieve their effects. The core difference lies in the specific bacterial strain used, which in turn determines the primary health benefits each product offers.
The Probiotic Strain in Align
The primary probiotic strain in Align Digestive Support is Bifidobacterium longum subsp. longum 35624 (previously known as Bifidobacterium infantis 35624). This unique, pure strain is supported by decades of research and has a strong reputation among gastroenterologists. Clinical studies, including a 2022 observational study, have confirmed its efficacy in managing and relieving symptoms of Irritable Bowel Syndrome (IBS), such as gas, bloating, and abdominal discomfort. The mechanism behind its effectiveness is strain-specific and relates to its ability to modulate the intestinal flora and immune response.
The Probiotic Strain in Culturelle
In contrast, Culturelle's core product line is built around the probiotic strain Lactobacillus rhamnosus GG (LGG). LGG is one of the most clinically studied probiotic strains worldwide, with over 1,000 scientific studies documenting its benefits. Its primary benefits are focused on managing acute infectious diarrhea, reducing the risk of antibiotic-associated diarrhea, and traveler's diarrhea. LGG functions by colonizing the intestinal walls and modulating the immune system to combat pathogenic bacteria and promote a healthier gut environment.
Comparing Primary Benefits
The most important distinction is that Align is specifically formulated for managing IBS symptoms, while Culturelle's LGG strain is primarily used for diarrhea prevention and treatment. Align's focus is on calming the abdominal discomfort, gas, and bloating often experienced by those with IBS. Culturelle's strength lies in its ability to restore bacterial balance disrupted by antibiotics, which is a common cause of diarrhea.
Factors to Consider When Choosing
- Targeted Condition: Do you suffer from IBS symptoms like persistent bloating and discomfort, or are you looking to prevent diarrhea, particularly when taking antibiotics? Your primary concern should guide your choice. Align's Bifidobacterium 35624 is the clinically studied strain for IBS, while Culturelle's LGG is the clinically studied strain for antibiotic-associated diarrhea.
- Ingredients and Allergies: Culturelle products are often noted as being soy-free, dairy-free, and vegetarian. Some Align formulations may contain milk ingredients. Always check the specific product's label to ensure it aligns with any dietary restrictions or allergies you may have.
- Product Form: Both brands offer various product forms, including capsules, gummies, and chewables. Align is known for its capsule-based delivery system, while Culturelle offers options for both adults and children.
- Price and Accessibility: While prices can vary, Culturelle products are often perceived as being more affordable and widely available. However, the cost should be weighed against the specific, targeted benefit of each strain.
Align vs. Culturelle Comparison Table
| Feature | Align (Main Formula) | Culturelle (Main Formula) |
|---|---|---|
| Primary Strain | Bifidobacterium longum subsp. longum 35624 | Lactobacillus rhamnosus GG (LGG) |
| Primary Use | Relieves and manages Irritable Bowel Syndrome (IBS) symptoms: abdominal discomfort, bloating, and gas. | Reduces risk of antibiotic-associated diarrhea and traveler's diarrhea. |
| CFU Count | Typically 1 billion CFU when manufactured. | Typically 10-20 billion CFU when manufactured. |
| Target User | Primarily adults seeking relief from IBS symptoms. | Adults, women, and children depending on the specific product. |
| Refrigeration Required? | No, shelf-stable and packaged to ensure potency until the 'best by' date. | No, also shelf-stable with advanced packaging to ensure potency. |
| Other Ingredients | May contain milk derivatives depending on the specific product formulation. | Often soy-free, dairy-free, and vegetarian. |
The Importance of Strain-Specific Benefits
The adage 'not all probiotics are the same' is particularly relevant when comparing these two brands. The effects of probiotics are highly strain-specific. A probiotic that effectively treats one condition may not be effective for another, even if the species name is similar. The clinical research supporting Align's ability to help with IBS is tied directly to the 35624 strain, just as Culturelle's anti-diarrhea benefits are linked to its LGG strain. Choosing a probiotic based on a brand name alone, rather than the specific, clinically studied strain it contains, can lead to disappointing results.
Conclusion
Align and Culturelle are both reputable probiotic brands, but they are not interchangeable. Align's core product, featuring Bifidobacterium longum subsp. longum 35624, is specifically designed for the management of IBS symptoms like bloating and abdominal pain. Culturelle, on the other hand, utilizes Lactobacillus rhamnosus GG and is primarily known for its ability to prevent and treat various forms of diarrhea, including antibiotic-associated diarrhea. For consumers, the choice between them should be driven by the specific digestive issue they wish to address. Consulting with a healthcare provider can provide personalized guidance to ensure the best possible outcome for your gut health. For further information on choosing a probiotic, consider reviewing resources like the International Scientific Association for Probiotics and Prebiotics (ISAPP) probiotic checklist.
Frequently Asked Questions
What is the main difference between Align and Culturelle? The main difference is the specific bacterial strain they use: Align contains Bifidobacterium longum subsp. longum 35624, which is clinically proven for managing IBS symptoms, while Culturelle uses Lactobacillus rhamnosus GG (LGG), which is widely studied for preventing and treating diarrhea.
Is it safe to take Align and Culturelle at the same time? While generally safe, it is not recommended to take multiple different forms of probiotics at the same time without consulting a healthcare provider. A doctor or pharmacist can help determine if this is necessary for your specific health needs.
Which probiotic is better for Irritable Bowel Syndrome (IBS)? Based on clinical research, Align, with its Bifidobacterium 35624 strain, is specifically formulated and proven to help relieve and manage IBS symptoms such as gas, bloating, and abdominal discomfort.
Which probiotic is better for diarrhea? Culturelle, which contains Lactobacillus rhamnosus GG, is a top choice for preventing antibiotic-associated diarrhea and traveler's diarrhea, as its benefits for these conditions are well-documented.
How can I tell if a probiotic will be effective? Effectiveness depends on the specific strain used, not just the brand. Look for products that clearly list the genus, species, and strain (e.g., Lactobacillus rhamnosus GG) on the label and have clinical research supporting the desired health benefit.
Do Align and Culturelle require refrigeration? No, both Align and Culturelle are formulated and packaged to be shelf-stable and do not require refrigeration to maintain their potency.
Can children take Align or Culturelle? Culturelle has a specific line of products for children, containing the LGG strain. Align is primarily formulated for adults, although specific products should always be checked for age appropriateness and with a pediatrician.
What are the side effects of taking these probiotics? Some users, particularly when first starting, may experience mild side effects like temporary gas, bloating, or abdominal gurgling. These symptoms usually subside with continued use as the body adjusts. If side effects persist, consult a healthcare professional.
How long does it take for Align or Culturelle to work? Some individuals may feel benefits in a few days, while for others it may take 10-14 days or longer for the digestive system to adjust and show improvement. Consistency is key for achieving the best results.
Can I get the same benefits from probiotic foods? While fermented foods like yogurt and kefir can offer beneficial bacteria, they may not contain the specific strains or high concentrations found in clinically-tested probiotic supplements like Align or Culturelle.
How does a probiotic help with antibiotics? Antibiotics can kill off both good and bad bacteria in your gut, leading to an imbalanced microbiome and potential diarrhea. A probiotic like Culturelle helps to restore and maintain a healthy bacterial balance during and after antibiotic use.
