Can You Take Iron Bisglycinate for Iron Deficiency? Efficacy, Benefits, and Dosage

According to the World Health Organization (WHO), iron deficiency is one of the most widespread nutritional disorders globally, affecting an estimated 2 billion people. For those diagnosed with this common condition, the question of whether you can take iron bisglycinate for iron deficiency is a relevant and important one.

Quick Summary

Iron bisglycinate, a highly bioavailable and well-tolerated iron supplement, is an effective treatment for iron deficiency due to its superior absorption and minimal side effects compared to traditional iron salts.

Key Points

• Superior Absorption: Iron bisglycinate is a chelated form of iron that is more readily absorbed by the body than traditional iron salts like ferrous sulfate.

• Gentle on the Stomach: Its chelated structure results in significantly fewer gastrointestinal side effects, such as constipation and nausea, enhancing patient tolerability.

• Effective for Iron Stores: Studies confirm that iron bisglycinate is highly effective at increasing serum ferritin levels, indicating that it successfully replenishes the body's iron reserves.

• Less Dietary Interference: Unlike other forms, iron bisglycinate is less affected by common dietary inhibitors like coffee, tea, and phytates found in grains and legumes.

• Maximizing Absorption: Combining the supplement with vitamin C can further enhance its absorption, while avoiding calcium and other inhibitors around the time of dosing is crucial.

• Important for Vulnerable Groups: Due to its mildness and efficacy, it is a particularly suitable option for sensitive individuals, pregnant women, and children.

Understanding Iron Bisglycinate

Iron bisglycinate, also known as ferrous bisglycinate, is a form of iron supplement where iron is bound to two molecules of the amino acid glycine. This chelated structure protects the iron from interactions with dietary inhibitors in the digestive system, leading to enhanced absorption compared to older iron salts. This improved absorption means more iron is available to the body to address low iron stores.

How It Works to Treat Iron Deficiency

Iron deficiency occurs when the body lacks sufficient iron to produce hemoglobin. Iron bisglycinate helps restore iron levels through:

• Enhanced Absorption: The chelated form allows for more efficient passage through the intestinal wall, making more iron available for use.
• Replenishing Stores: It effectively increases ferritin levels, which measure stored iron, crucial for long-term health and preventing recurring deficiency.
• Promotes Regulation: Absorption may be regulated by the body based on need, potentially reducing the risk of overload in those with sufficient levels.

Benefits Over Traditional Iron Salts

Traditional iron supplements like ferrous sulfate are often associated with gastrointestinal issues. Iron bisglycinate is known for being gentler on the stomach, causing fewer side effects such as nausea, constipation, and cramps. This improved tolerability can lead to better adherence to treatment and more successful outcomes.

Comparing Iron Bisglycinate and Ferrous Sulfate

Feature	Iron Bisglycinate	Ferrous Sulfate
Bioavailability	High; greater absorption due to chelated form.	Lower; less efficiently absorbed by the body.
Gastrointestinal Side Effects	Low incidence; generally gentle on the stomach.	High incidence; common issues include nausea and constipation.
Dosage	Effective at lower elemental iron doses.	Often requires higher doses, which increases side effects.
Interaction with Food	Less prone to interference from dietary inhibitors like phytates.	Highly susceptible to reduced absorption when taken with foods like dairy and coffee.
Cost	Generally more expensive due to advanced formulation.	Inexpensive and widely available.
Effect on Ferritin	Effectively increases ferritin (iron stores).	May be less effective at replenishing iron stores.

How to Take Iron Bisglycinate for Best Absorption

To optimize absorption of iron bisglycinate:

1. Empty Stomach: Take at least one hour before or two hours after eating.
2. Vitamin C: Combining with vitamin C can boost absorption.
3. Avoid Inhibitors: Do not take with calcium-rich foods, tea, or coffee.
4. Alternate-Day Dosing: Some studies suggest this may improve absorption.
5. Consistency: Regular dosing is essential for treatment and rebuilding stores.

Potential Side Effects

Though generally well-tolerated, some mild side effects can occur. These may include:

• Mild digestive discomfort
• Nausea
• Constipation or diarrhea
• Dark stools

Consult a healthcare provider if side effects persist or are severe.

Conclusion

Iron bisglycinate is a safe and effective oral supplement for iron deficiency. Its superior absorption and lower incidence of gastrointestinal side effects compared to traditional forms make it a preferred option for many. Proper dosing and timing can maximize its benefits. Always consult a healthcare professional for diagnosis and a personalized treatment plan for iron deficiency. The chelated form of iron bisglycinate offers a well-tolerated approach to restoring essential iron levels.

The effects of oral ferrous bisglycinate supplementation on hemoglobin and ferritin concentrations and gastrointestinal adverse events: A systematic review and meta-analysis of randomized controlled trials.

Frequently Asked Questions

What is the difference between iron bisglycinate and ferrous sulfate?

Iron bisglycinate is a newer, chelated form of iron with higher bioavailability and fewer gastrointestinal side effects, like constipation, compared to the traditional and less expensive ferrous sulfate.

How long does it take for iron bisglycinate to work?

While individuals may start feeling better within a few weeks, it typically takes several months of consistent supplementation to fully correct an iron deficiency and replenish the body's iron stores. Your doctor will monitor your blood levels to determine the total duration of treatment.

Can I take iron bisglycinate with food?

For optimal absorption, it is best to take iron bisglycinate on an empty stomach. However, if it causes stomach upset, taking it with a light meal can reduce discomfort, though absorption may be slightly decreased.

What should I avoid when taking iron bisglycinate?

Avoid taking calcium supplements, dairy products, coffee, and tea within two hours of your iron bisglycinate dose, as they can interfere with iron absorption.

Is iron bisglycinate safe during pregnancy?

Yes, iron bisglycinate is considered a safe and effective option for treating iron deficiency during pregnancy. It is well-tolerated and can successfully increase hemoglobin levels.

Are there any side effects from taking iron bisglycinate?

While generally milder than other forms, potential side effects can include nausea, constipation, stomach pain, or dark stools. These are often manageable by adjusting the dosage or timing.

What are the signs of iron deficiency?

Common symptoms include fatigue, weakness, pale skin, shortness of breath, headache, dizziness, and brittle nails. A blood test is necessary for a definitive diagnosis.