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Is AlgaeCal Strontium Safe? Understanding the Citrate vs. Ranelate Distinction

4 min read

According to research published in the Journal of the American College of Nutrition, some participants who combined AlgaeCal with strontium citrate saw significant increases in bone density over several years without adverse side effects. This clinical support raises the question: is AlgaeCal strontium safe for everyone? The answer requires understanding the critical distinction between the natural mineral form found in the supplement and a different, higher-risk prescription drug.

Quick Summary

The safety of AlgaeCal's strontium depends on clarifying which form is being discussed. The supplement contains natural strontium citrate, which differs fundamentally from the prescription drug strontium ranelate, known for serious side effects and cardiovascular risks. For most healthy users, when separated from calcium intake, AlgaeCal's strontium citrate is considered safe, though precautions apply.

Key Points

  • Strontium Citrate vs. Ranelate: AlgaeCal uses strontium citrate, a natural mineral supplement, not the prescription drug strontium ranelate, which has been linked to serious cardiovascular side effects.

  • Generally Safe for Most Adults: For healthy individuals, strontium citrate is considered safe when taken correctly and at recommended dosages, as supported by clinical studies on AlgaeCal products.

  • Important Health Precautions: Individuals with kidney problems, heart disease, blood clotting disorders, and pregnant or breastfeeding women should avoid strontium supplements.

  • Timing is Crucial for Absorption: To ensure effective absorption, AlgaeCal's strontium citrate must be taken at least two hours away from calcium supplements or calcium-rich foods.

  • DEXA Scan Considerations: Strontium can cause DEXA scan results to appear higher than actual bone mineral density, a factor that needs to be considered when interpreting results.

  • Dual Action Bone Support: Strontium works by both stimulating bone-building cells (osteoblasts) and inhibiting bone-resorbing cells (osteoclasts).

In This Article

The question of whether AlgaeCal's strontium is safe is rooted in a widespread confusion between two different forms of the mineral: strontium citrate and strontium ranelate. While both have been studied for their effects on bone health, their safety profiles are vastly different. AlgaeCal uses the natural and widely available supplement form, strontium citrate, not the controversial prescription drug, strontium ranelate.

Natural Strontium Citrate vs. Prescription Strontium Ranelate

The most important factor in assessing the safety of AlgaeCal's strontium is recognizing that it is the citrate form. Strontium is a trace element found naturally in soil and food. AlgaeCal's Strontium Boost provides a specific dose of strontium citrate to complement its plant-based calcium supplement.

In contrast, strontium ranelate is a pharmaceutical drug that was once used to treat osteoporosis in Europe but is now restricted due to safety concerns. Unlike strontium citrate, strontium ranelate has been associated with serious health risks, including cardiovascular issues and blood clots. It is crucial to understand these differences when evaluating any product containing strontium.

The Mechanism of Strontium for Bone Health

Stable strontium, when incorporated into bone, has a unique dual action that helps to improve bone mineral density (BMD).

  • Stimulates Osteoblasts: Strontium encourages osteoblasts, the bone-building cells, to increase new bone formation.
  • Inhibits Osteoclasts: It simultaneously slows down the activity of osteoclasts, which are the cells responsible for breaking down old bone.

This combined effect helps rebalance the natural bone remodeling process, leading to a net gain in bone mass over time. This mechanism applies to both forms of strontium, but the attached compound (citrate vs. ranelate) dictates the overall safety profile.

Safety Profile of AlgaeCal's Strontium Citrate

Clinical studies, many involving AlgaeCal products, suggest that the strontium citrate form is generally well-tolerated and safe for most healthy individuals at the recommended dosages. A 7-year study on AlgaeCal Plus and Strontium Boost found that participants experienced increased bone density with no reported adverse side effects. However, specific precautions and potential side effects should be noted.

  • Gastrointestinal Issues: Some users may experience mild digestive side effects, such as diarrhea, particularly when starting supplementation.
  • Kidney Function: Strontium is eliminated by the kidneys. Individuals with pre-existing kidney problems or chronic kidney disease should avoid strontium supplements, as buildup can occur.
  • Interactions: Strontium competes with calcium for absorption. For optimal effectiveness, strontium citrate should be taken at least two hours away from calcium supplements or high-calcium foods.
  • DEXA Scan Results: Strontium can affect bone density scans, causing an overestimation of BMD. This is because strontium is denser than calcium and replaces some calcium in the bone matrix. Most experts suggest adjusting DEXA results downward by approximately 10% to account for this effect, but even with this adjustment, studies still show true increases in BMD with strontium supplementation.

Potential Risks and Cautions

While generally safe, there are specific populations for whom strontium supplements are not recommended:

  • Pregnant or Breastfeeding Women: Due to a lack of sufficient safety data, strontium supplements should be avoided during pregnancy and lactation.
  • Individuals with Pre-existing Conditions: Those with a history of cardiovascular disease, blood clotting disorders, or advanced kidney disease should avoid strontium supplements.
  • High Dosages: Very high doses of elemental strontium, well beyond the recommended supplement amount, could potentially be harmful to bones.

Comparison: Strontium Citrate vs. Strontium Ranelate

Feature Strontium Citrate (AlgaeCal) Strontium Ranelate (Protelos)
Source/Form Natural, over-the-counter supplement Synthetic, prescription drug
Primary Use Bone mineral density support Osteoporosis treatment (in some countries)
Availability Over-the-counter in most regions, including the U.S. Restricted in Europe; not approved in the U.S. or Canada
Serious Side Effects Generally rare; typically mild GI issues Cardiovascular risks, blood clots, DRESS syndrome
Interaction with Calcium Must be taken separately from calcium for optimal absorption Must be taken separately from calcium for optimal absorption
Regulation FDA does not evaluate dietary supplements for safety or efficacy Heavily regulated; withdrawn or restricted in many regions

Conclusion: Making an Informed Decision

For most healthy individuals seeking to support bone health, AlgaeCal's strontium citrate is considered safe when taken according to directions, particularly the separation from calcium intake. The product's safety is often confused with that of the pharmaceutical drug strontium ranelate, which carries serious and well-documented risks. However, individuals with specific health conditions, such as kidney, heart, or blood clotting issues, should avoid strontium supplements. As with any dietary supplement, consulting a healthcare provider before starting AlgaeCal Strontium Boost is the best way to ensure it is appropriate for your individual health needs. Given that the long-term effects on certain populations and potential medication interactions are still being researched, medical supervision is always recommended.

Choosing a Safe Supplement Protocol

When considering AlgaeCal with strontium, adopting a safe protocol involves:

  • Consulting a Doctor: A healthcare professional can assess your specific health profile, especially if you have pre-existing conditions, to determine if strontium citrate is right for you.
  • Following Dosing Instructions: Always adhere to the recommended dosage and timing instructions to maximize absorption and reduce the risk of side effects.
  • Timing is Key: Take strontium citrate and calcium supplements at least two hours apart to prevent competition for absorption.
  • Monitoring Health: Pay attention to any new symptoms and discuss them with your doctor. This is particularly important for individuals with any underlying health concerns.
  • Considering Alternatives: For those who cannot take strontium, other bone health strategies, including diet, exercise, and alternative supplements, are available.

Following these guidelines helps ensure a safe and effective approach to using AlgaeCal's strontium citrate to support bone health.


Note: This article is for informational purposes only and does not constitute medical advice. Please consult a qualified healthcare professional before beginning any new supplement regimen.

Frequently Asked Questions

Strontium citrate is a natural, over-the-counter supplement, whereas strontium ranelate is a synthetic, prescription drug. Strontium ranelate has been associated with serious risks like cardiovascular problems, unlike strontium citrate.

Strontium and calcium compete for absorption in the gut. To maximize the effectiveness of AlgaeCal's Strontium Boost, it must be taken at least two hours apart from any calcium supplements or calcium-rich foods.

Individuals with compromised kidney function, heart disease, blood clotting disorders, as well as pregnant or breastfeeding women should avoid strontium supplements.

Yes. Strontium is denser than calcium and can cause an overestimation of bone mineral density (BMD) on DEXA scans. Adjustments are often necessary to get an accurate reading of true BMD changes.

Side effects from natural strontium citrate are rare and usually mild, with some people reporting minor gastrointestinal issues. More serious risks are linked to the drug strontium ranelate, not the supplement.

As a dietary supplement, AlgaeCal and its strontium component are not evaluated or approved by the FDA for safety or efficacy, as is standard for all supplements. The FDA has not approved the prescription drug strontium ranelate for use in the US due to safety concerns.

Strontium has a dual mechanism of action: it stimulates osteoblasts (cells that build bone) and inhibits osteoclasts (cells that break down bone). This dual effect helps increase bone mineral density.

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Medical Disclaimer

This content is for informational purposes only and should not replace professional medical advice.